1.
JACC Basic Transl Sci
; 4(6): 717-732, 2019 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31709320
RESUMO
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.