Smoking during pregnancy and gestational diabetes mellitus: a systematic review and meta-analysis.

PURPOSE: To investigate whether maternal cigarette smoking during pregnancy is a risk factor for developing GDM. METHODS: MEDLINE, Scopus, CENTRAL and Google Scholar databases were searched from inception to December 2022 to identify eligible original articles. A systematic review and meta-analysis (weighted data, random-effects model) were performed. The primary outcome was the development of GDM in pregnant women. The results were expressed as odds ratios (OR) with 95% confidence interval (CI) (inverse variance method). Subgroup analysis was planned according to the maternal smoking status and GDM diagnostic criteria. Statistical heterogeneity was checked with the Chi-squared (Chi2) test and the I2 index was used to quantify it. The studies were evaluated for publication bias. RESULTS: Thirty-five studies, including 23,849,696 pregnant women, met the inclusion criteria. The pooled OR of smoking during pregnancy compared with non-smoking (never smokers and former smokers) was 1.06 (95% CI 0.95-1.19), p = 0.30; I2 = 90%; Chi2 = 344; df=34; p < 0.001. Subgroup analysis was performed according to the two-step Carpenter-Coustan diagnostic criteria, due to the high heterogeneity among the other applied methods. The pooled OR for the Carpenter-Coustan subgroup was 1.19 (95% CI 0.95-1.49), p = 0.12; I2 = 63%; Chi2 = 27; df=10; p < 0.002. Further subgroup analysis according to maternal smoking status was not performed due to missing data. CONCLUSION: There is no evidence to support an association between maternal cigarette smoking during pregnancy and the risk for GDM. Universally accepted diagnostic criteria for GDM must be adopted to reduce heterogeneity and clarify the association between smoking and GDM.

Thyroid ultrasonographic charasteristics and Bethesda results after FNAB.

PURPOSE: Thyroid nodular disease (TND) is a frequent clinical problem and the major concern is the probability of malignancy in a solitary nodule or in one or more nodules of a multinodular goiter. For this purpose, neck ultrasound and fine needle aspiration biopsy (FNAB) under ultrasound guidance have been established as the initial investigation of choice. METHODS: A total of 1113 patients (210 male/903 female) underwent FNABs for the same number of thyroid nodules. Correlated were the demographic profile (age and gender) and sonographic features of these nodules with the FNAB outcome. The Bethesda system (B) for reporting thyroid cytopathology was used. RESULTS: Out of total 1113 cases, 255 (22.9%) were characterised as nondiagnostic (B1), 780 (70.1%) were diagnosed as benign (B2), 35 (3.1%) were diagnosed as B3 (atypia/ follicular lesion of undetermined significance), 10 (0.9%) were diagnosed as B4 (follicular neoplasm or suspicious for follicular neoplasm), while 13 (1.2%) cases were categorized as B5 (suspicious for malignancy) and 20 (1.8%) as B6 (malignant). When comparing the sonographic features of nodules with benign cytology (category B2) vs those of nodules with cytology category B3-6, irregular shape and ill-defined margins of the nodule, and microcalcifications and the hypoechogenicity increased significantly the possibility for a B3-B6 cytology result (p<0.05). Finally, there was no association of gender and age with the (B) category results. CONCLUSION: The aforementioned sonographic findings decrease the possibility for a benign cytology result according to the Bethesda classification system. Key words: Bethesda classification system, fine needle aspiration biopsy, thyroid nodules, thyroid ultrasound.

Association of Basal and Calcium-stimulated Calcitonin Levels with Pathological Findings After Total Thyroidectomy.

BACKGROUND/AIM: Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin-secreting tumor. Calcitonin is also elevated in C-cell hyperplasia (CCH). The objective of the study was to determine the optimal basal (bCT) and peak stimulated calcitonin (psCT) cut-off value for differentiating MTC from CCH, and to examine the histological findings of thyroidectomy in patients with maximum psCT >100 pg/ml. PATIENTS AND METHODS: Fifty-five patients had a maximum calcium-psCT >100 pg/ml and underwent total thyroidectomy. RESULTS: A total of 20 patients were diagnosed with MTC and the remaining 35 with CCH. A bCT level >17.4 pg/ml and psCT level >452 pg/ml demonstrated the best sensitivity and positive predictive value for differenting MTC from CCH. CONCLUSION: The overlap of calcitonin levels between MTC and CCH reduces the accuracy of the calcium stimulation test. Remarkably, an appreciable number of patients with psCT levels >100 pg/ml harbor differentiated thyroid carcinoma of follicular origin.