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Carbohydr Polym ; 245: 116547, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32718640

RESUMO

In this report, polysaccharides - alginate, fucoidan, laminaran - were isolated from marine algae Saccharina cichorioides and Fucus evanescens and their activity as a reducing and stabilizing agents in the biogenic synthesis of silver nanoparticles was evaluated. The cytotoxic and antibacterial properties of obtained nanoparticles were also assessed. It was found that all tested polysaccharides could be used as a reducing agent; however, their catalytic activities varied significantly in the following range alginate < fucoidan < laminaran. Nanoparticles demonstrated cytotoxicity against rat C6 glioma cells. It was considerably higher for alginate- and laminaran-obtained nanosilver samples compared to fucoidan. Additionally, silver nanoparticles possessed considerable antibacterial properties more pronounced in fucoidan-obtained samples. Our data demonstrate that different algal polysaccharides can be used for the synthesis of silver nanoparticles with varying bioactivities.


Assuntos
Alginatos/química , Antibacterianos/química , Excipientes/química , Glucanos/química , Nanopartículas Metálicas/química , Phaeophyceae/química , Polissacarídeos/química , Substâncias Redutoras/química , Prata/química , Agrobacterium tumefaciens/efeitos dos fármacos , Alginatos/isolamento & purificação , Animais , Antibacterianos/farmacologia , Catálise , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Glucanos/isolamento & purificação , Polissacarídeos/isolamento & purificação , Ratos , Alga Marinha/química
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