RESUMO
OBJECTIVE: To investigate the association of thrombophilia and coronary artery disease (CAD) in patients with myocardial infarction (MI). METHODS: Under the age of 45 years, 129 patients with MI and 107 control subjects were included into the study. Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated. RESULTS: There were statistically significant differences in terms of obesity, smoking, triglyceride, total cholesterol, high-density lipoprotein, high-density lipoprotein, and very-low-density lipoprotein cholesterol, family history, hypertension, diabetes, and left ventricular hypertrophy between patients and controls. None of the patients and controls had protein C, protein S, and antithrombin III deficiencies. Ten patients (7.8%) and 4 controls (3.7%) had heterozygote FV Leiden mutation. Homozygous prothrombine G20210A gene mutation was detected in one patient (1.1%). Homozygous MTHFR C677T mutation was observed in 7.8% (patients) and in 6.5% (controls). Heterozygous MTHFR C677T mutation was detected 36.4% in patients and 31.7% in controls. The difference was not statistically significant in terms of carriage of thrombophilic mutations. CONCLUSION: We found that traditional risk factors increased the risk of CAD. Prothrombin G20210A, FV Leiden and MTHFR C677T mutations, protein C, S and AT-III deficiencies did not increase the risk of CAD in our young population.
Assuntos
Infarto do Miocárdio/sangue , Trombofilia/sangue , Adulto , Antitrombina III/metabolismo , Estudos de Casos e Controles , DNA/análise , Fator V/metabolismo , Feminino , Humanos , Modelos Logísticos , Masculino , Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo , Mutação , Infarto do Miocárdio/genética , Proteína C/metabolismo , Proteína S/metabolismo , Protrombina/metabolismo , Fatores de Risco , Trombofilia/genéticaRESUMO
Left ventriculoatrial fistula is a very rare cardiac disorder. The case is reported of a male patient who was admitted to the authors' clinic with dyspnea and fatigue. The patient had an atrioventricular fistula between the left atrium and left ventricle, and had undergone aortic valve re-replacement for prosthesis malfunction about one year previously. The fistula was considered to be the result of iatrogenic injury related to valve re-replacement surgery.
Assuntos
Valva Aórtica/cirurgia , Fístula Arteriovenosa/etiologia , Implante de Prótese de Valva Cardíaca/métodos , Idoso , Valva Aórtica/diagnóstico por imagem , Fístula Arteriovenosa/diagnóstico por imagem , Ecocardiografia , Ecocardiografia Transesofagiana , Átrios do Coração/diagnóstico por imagem , Doenças das Valvas Cardíacas/diagnóstico por imagem , Doenças das Valvas Cardíacas/cirurgia , Implante de Prótese de Valva Cardíaca/efeitos adversos , Ventrículos do Coração/diagnóstico por imagem , Humanos , Hipertrofia Ventricular Esquerda/diagnóstico por imagem , Hipertrofia Ventricular Esquerda/etiologia , Masculino , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Falha de Prótese , Reoperação/efeitos adversosAssuntos
Angina Pectoris/induzido quimicamente , Antimetabólitos Antineoplásicos/efeitos adversos , Vasoespasmo Coronário/induzido quimicamente , Fluoruracila/efeitos adversos , Adenocarcinoma/tratamento farmacológico , Adulto , Angina Pectoris/diagnóstico , Angina Pectoris/tratamento farmacológico , Neoplasias Colorretais/tratamento farmacológico , Angiografia Coronária , Vasoespasmo Coronário/diagnóstico , Eletrocardiografia , Humanos , Masculino , Nitroglicerina/uso terapêutico , Resultado do TratamentoRESUMO
Cardiac hydatid cyst is an uncommon disease. We report on a woman admitted to our clinic with chest pain and palpitations. The ECG showed anterior ischemia, and coronary anatomy was normal. The diagnosis was: multiple cardiac hydatid cysts, for which she had undergone surgery 4 years earlier for a 5 x 5 hydatid cyst and treated with albendazole. Despite this, there was a recurrence of multiple cysts. Recurrence of intracavitary hydatid cyst is rare, and surgical treatment of multiple, small cysts remains controversial.