[Beyond Slapstick: How Silent Movies Have Witnessed Medicine]. / Nicht nur Slapstick: Stummfilme als unterschätzte Zeugen der Medizingeschichte.

Medicine in silent film has a long history. Although the silent era in cinema was dominated by burlesques (using escaped "lunatics") a number of themes emerged after systematic review. The cinematic representation of medicine coincided with the discovery of X-rays. During this "roentgenomania", short films were produced showing groundbreaking X-ray images, which fitted perfectly into needs of dramatic cinema. But soon the "cinema of narration" evolved: Starting just after the turn of the century, the short film "The Country Doctor" was able to address complex interplay between duties and limitations of the medical profession. This was followed by numerous feature films on infectious diseases, which often used tuberculosis as a centerpiece of its story. Directors often took advantage of the well-known stereotype of the omnipotent physician. But in certain medical fields, such as psychiatry or surgery, a more ambivalent figure of the doctor was portrayed, f. e. in "Hands of Orlac" (1924). Silent cinema also offered interesting ideas on the healing powers of the medium itself: in "The Mystery of the Kador Cliffs" (1912) a film screening could cure the patient of fears after reenactment. Finally, a closer look at the early era of film echoes how social conflicts where dramatized, especially in the case of nationwide birth control. How illegal abortion kept the society on its edge, was most clearly shown in the adaption of the scandalous play "Cyankali" (1930).In addition to discussing various topics in the cinematic representation of medicine, this brief overview shows that silent movies were a new and true art form, representing an exceptional resource for historians of film and medicine.

[The two CVs of Klaus Joachim Zülch (1910-1988)]. / Die zwei Lebensläufe des Klaus Joachim Zülch (1910­1988).

Klaus Joachim Zülch's research on the pathology and biology of brain tumors made him one of the outstanding scholars and clinicians in the fields of neurology and neuropathology in the Federal Republic of Germany. The World Health Organization (WHO) drew on his results when laying down its classification. In the years 1961-1962 he was president of the German Neurological Society (DGN), in 1978 he became an honorary member and in 1984 honorary president. In addition to the Zülch Award of the Max Planck Society, the DGN organizes a Zülch lecture at its annual meetings. Archive documents revealed that he was an early adherent of the ideology of National Socialism. He was a member of paramilitary units, joined the SA storm troopers in 1933 and the National Socialist German Workers' Party (NSDAP) in 1937. After having studied under Otfrid Foerster in Breslau and Georg Schaltenbrand in Würzburg he served as a military physician and in army hospitals during and after WWII. Nevertheless, he continued his investigations at the Kaiser Wilhelm Institute for Brain Research with Wilhelm Tönnis. In July 1947 he was dismissed on account of his SA membership but entered an objection to this decision of the Allies. After a lengthy denazification trial he succeeded in being exonerated. This was also due to attestations written in his favor by various neuroscientists. Hence, he could pursue his career in Cologne and from 1959 onwards he acted as director of the newly established department of general neurology of the Max Planck Institute and simultaneously as head of the department for clinical neurology at Cologne-Merheim hospital. The juxtaposition of a CV written by Zülch himself around 1938 with another one composed after the war shows that he tried to conceal incriminating facts and partly reconstructed a new and ultimately successful biography.

Paramunity-inducing Factors (PINDs) in dendritic cell (DC) cultures lead to impaired antileukemic functionality of DC-stimulated T-cells.

INTRODUCTION: Paramunity-inducing-Factors (PINDs) consist of attenuated/inactivated viruses of various poxvirus-genera, used in veterinary medicine as non-antigen-specific, non-immunising stimulators of the innate immune system against infectious and malignant diseases. Their danger-signaling-interactions were tested for their capacity to improve leukemic antigen-presentation on DC generated from AML-patients' blasts ('DCleu') and DC-stimulation/activation of antileukemic T-cells. METHODS: We analyzed, whether the addition of PINDs during DC cultures (15 healthy, 22 leukemic donors) and mixed lymphocyte culture (MLC, n = 15) with autologous (n = 6), allogeneic (n = 2) or T-cells after stem cell transplantation (SCT; n = 7) would alter the quality and quantity of DC, the composition of T-cell-subsets, and/or their antileukemic functionality (AF) as studied by FACS and functional Fluorolysis-cytotoxicity-assays. RESULTS: Effects on 1. DC-cultures: PINDs in DC-cultures lead to increased proportions of mature DC and DCleu, but reduced proportions of viable and overall, as well as TLR4- and TLR9-expressing DC. 2. MLC: PINDs increased early (CD8+) T-cell activation (CD69+), but reduced proportions of effector-T-cells after MLC 3. AF: Presence of PINDs in DC- and MLC-cultures reduced T-cells' as well as innate cells' antileukemic functionality. 4. Cytokine-release profile: Supernatants from PIND-treated DC- and MLC-cultures resembled an inhibitory microenvironment, correlating with impaired blast lysis. CONCLUSIONS: Our data shows that addition of PINDs to DC-cultures and MLC result in a "blast-protective-capacity" leading to impaired AF, likely due to changes in the composition of T-/innate effector cells and the induction of an inhibitory microenvironment. PINDs might be promising in treating infectious diseases, but cannot be recommended for the treatment of AML-patients due to their inhibitory influence on antileukemic functionality.

Mercy killing in neurology: The beginnings of neurology on screen (II).

The history of Neurocinema includes neuroethics, and this theme was first used in 2 films released in the 1940s in both Germany and the United States. Ich Klage An (I Accuse) is about "terminal" multiple sclerosis in a young woman and the decision to determine one's own fate. The protagonist anticipates becoming "deaf, blind, and idiotic" and asks her husband to administer a toxic drug dose, which he does. The film disturbingly suggests that the diagnosis of multiple sclerosis is tantamount to a death sentence. Ich Klage An (1941) played during the medical murders era ("Aktion T-4" program) but has few references to National Socialism, except for judges with Nazi emblems on their robes making a brief Nazi salute and a jury chamber with a bust of Hitler. Party leadership agreed that the film made a deep impression, but the intended effect on the viewing public is largely unknown. An Act of Murder (1948) involves another young woman with an inoperable brain tumor. When her condition worsens during a trip, her husband deliberately crashes the car, killing her but surviving himself. A subsequent trial finds that she died of an overdose rather than the crash. The trial judge dismisses the murder charge, but the film argues the morals of mercy killing. These films came out during the Nazi euthanasia program and founding of the Euthanasia Society of America in 1938. The choice of neurologic disease by these filmmakers and scriptwriters to defend euthanasia is remarkable.