[Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of ß-amyloid-associated brain diseases]. / Digidrokvertsetin kak sistemnyi neiroprotektor dlya profilaktiki i lecheniya ß-amiloid-assotsiirovannykh zabolevanii golovnogo mozga.

Dihydroquercetin (DHQ) is a plant-derived polyphenol belonging to the group of flavonoids. In models associated with abnormal accumulation of ß-amyloid in the brain (Alzheimer's disease and cerebral amyloid angiopathy), DHQ demonstrates the ability to disaggregate toxic forms of ß-amyloid and prevent their formation. It is believed that this phenomenon underlies the protective effect of DHQ on brain neurons. However, pharmacokinetic data doubt the central mechanism of action of DHQ because this compound does not penetrate well into the brain. A hypothesis is put forward about the systemic nature of the neuroprotective action of DHQ, since this compound has multiple biological activities at the level of the whole organism. To characterize DHQ (and similar compounds), it is proposed to introduce the term «systemic neuroprotector¼.

[Anthocyanins for the prevention and treatment of neurodegenerative diseases]. / Antotsiany dlya profilaktiki i lecheniya neirodegenerativnykh zabolevanii.

Anthocyanins are water-soluble polyphenolic pigments widely present in fruits and vegetables. These compounds have extensive biological activity and are able to penetrate the brain and modulate its functions. In neurodegenerative processes, anthocyanins contribute to the survival of neurons. The mechanisms of the neuroprotective action of anthocyanins are associated with their antioxidant, anti-inflammatory, antitoxic, and anti-apoptotic activities. The ability of anthocyanins to act on multiple therapeutic targets at once makes them useful for the prevention and treatment of the initial stages of neurodegenerative diseases. Anthocyanins have low stability and bioavailability which creates problems for their therapeutic use. Methods for the stabilization and delivery of anthocyanins into the body are considered.