Assuntos
Arterite/diagnóstico , Lúpus Eritematoso Sistêmico/complicações , Doenças Raras/diagnóstico , Dermatopatias Vasculares/diagnóstico , Adulto , Arterite/imunologia , Arterite/patologia , Biópsia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/imunologia , Pessoa de Meia-Idade , Doenças Raras/imunologia , Doenças Raras/patologia , Pele/irrigação sanguínea , Pele/imunologia , Pele/patologia , Dermatopatias Vasculares/imunologia , Dermatopatias Vasculares/patologiaAssuntos
Dermatomiosite/complicações , Doenças Pulmonares Intersticiais/etiologia , Psoríase/etiologia , Pele , Adulto , Biópsia , Dermatomiosite/diagnóstico , Dermatomiosite/tratamento farmacológico , Dermatomiosite/imunologia , Feminino , Humanos , Imunossupressores/uso terapêutico , Doenças Pulmonares Intersticiais/diagnóstico , Doenças Pulmonares Intersticiais/tratamento farmacológico , Doenças Pulmonares Intersticiais/imunologia , Psoríase/diagnóstico , Psoríase/tratamento farmacológico , Psoríase/imunologia , Recidiva , Pele/efeitos dos fármacos , Pele/imunologia , Pele/patologia , Resultado do TratamentoAssuntos
Artrite Psoriásica/patologia , Melanoma/patologia , Administração Cutânea , Corticosteroides/administração & dosagem , Corticosteroides/uso terapêutico , Antirreumáticos/uso terapêutico , Artrite Psoriásica/tratamento farmacológico , Dor nas Costas/tratamento farmacológico , Biópsia , Colecalciferol/administração & dosagem , Colecalciferol/uso terapêutico , Células Dendríticas/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Melanoma/induzido quimicamente , Metotrexato/efeitos adversos , Metotrexato/uso terapêutico , Pessoa de Meia-Idade , Pomadas , Terapia PUVA/efeitos adversos , Retinoides/uso terapêutico , Índice de Gravidade de Doença , Neoplasias Cutâneas , Melanoma Maligno CutâneoRESUMO
Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs. Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature. We herein describe three Japanese cases of ichthyosiform sarcoidosis on the lower limbs. All of the patients were female, with an age range of 57-69 years old. Histologically, sarcoidal granulomas were located in the mid- to lower dermis. All cases had scar sarcoidosis on the knees. Furthermore, Case 1 presented with papular sarcoidosis on the back, and Case 3 presented with subcutaneous nodules on the buttock as well as erythema nodosum-like lesions on the lower legs. All patients had lung sarcoidosis, but ocular sarcoidosis was seen in only Case 2. Case 3 showed Heerfordt syndrome with facial nerve paralysis. Histological features showed that the granular layers were scarcely detected in the overlying epidermis; however, filaggrin expression was not decreased. Sarcoidal granulomas accumulated around the sweat glands in one case, whereas those features were not detected in the other two cases. In conclusion, ichthyosiform cutaneous sarcoidosis may be overlooked or misdiagnosed as xerotic dry skin which is frequently found in elderly people, and ichthyosiform cutaneous lesions may be more prevalent than previously estimated.
Assuntos
Ictiose/diagnóstico , Sarcoidose/diagnóstico , Pele/patologia , Idoso , Dorso , Biópsia , Nádegas , Feminino , Proteínas Filagrinas , Humanos , Extremidade Inferior , Pessoa de Meia-Idade , Sarcoidose/patologiaAssuntos
Hiperostose Esternocostoclavicular/complicações , Pioderma Gangrenoso/complicações , Pioderma Gangrenoso/patologia , Feminino , Granuloma/complicações , Granuloma/patologia , Humanos , Hiperostose Esternocostoclavicular/diagnóstico por imagem , Interleucina-17/metabolismo , Pessoa de Meia-Idade , Pioderma Gangrenoso/imunologia , Cintilografia , TecnécioAssuntos
Pustulose Exantematosa Aguda Generalizada/etiologia , Dermatite Esfoliativa/tratamento farmacológico , Isoniazida/efeitos adversos , Psoríase/tratamento farmacológico , Pustulose Exantematosa Aguda Generalizada/diagnóstico , Antituberculosos/efeitos adversos , Biópsia , Dermatite Esfoliativa/complicações , Humanos , Isoniazida/uso terapêutico , Masculino , Pessoa de Meia-Idade , Psoríase/complicaçõesRESUMO
BACKGROUND: Although the etiology of Behçet's disease (BD) is still unknown, neutrophils are implicated in its pathogenesis. Growth-related oncogene-α (GRO-α) is a potent chemoattractant and activator for neutrophils. OBJECTIVE: To determine the role of GRO-α in the pathogenesis of BD, we investigated serum GRO-α levels in patients with BD. MATERIALS AND METHODS: Sera from patients with BD (n=57) and control subjects (n=26) were measured by enzyme-linked immunosorbent assay. Serum levels of GRO-α were compared with clinical symptoms. RESULTS: Patients with BD had significantly elevated serum GRO-α levels compared with healthy controls (121.7±79.2pg/ml vs. 75.9±20.6pg/ml, P<0.01). Concerning the subgroups of BD, serum GRO-α levels in active patients with BD (n=35) were significantly higher than in inactive patients with BD (n=22; 139.0±92.8 pg/ml vs. 94.3±36.2pg/ml, P<0.05). Also, as seen in previous studies, serum interleukin-8 levels in patients with BD (52.4±81.8pg/ml) were significantly higher than in controls (13.9±19.7pg/ml, P<0.01). Enhanced GRO-α levels correlated with clinical symptoms such as erythema nodosum. CONCLUSION: Our results indicate that serum levels of GRO-α are elevated in patients with active stage BD, suggesting that GRO-α may serve as a reliable marker for disease activity of BD.
Assuntos
Síndrome de Behçet/sangue , Quimiocina CXCL1/sangue , Adolescente , Adulto , Idoso , Síndrome de Behçet/patologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemAssuntos
Artrite Reumatoide/complicações , Artrite Reumatoide/patologia , Úlcera da Perna/patologia , Úlcera Cutânea/patologia , Feminino , Humanos , Úlcera da Perna/complicações , Pessoa de Meia-Idade , Úlcera Cutânea/complicações , Úlcera Cutânea/imunologia , Insuficiência Venosa/complicações , Insuficiência Venosa/imunologia , Insuficiência Venosa/patologiaRESUMO
A 67-year-old woman with rheumatoid arthritis (RA) treated with systemic prednisolone and methotrexate over 20 years developed eruptive molluscum contagiosums on the trunk and extremities. Investigation revealed lung cancer 2 years later. Newly development of molluscum contagiosums ceased after the surgical operation of lung cancer. Immunologic dysfunctions have been shown in RA, and especially patients under long-term methotrexate therapy are susceptible to miscellaneous skin conditions. Eruptive molluscum contagiosums are induced in association with hematologic malignancies such as lymphoma, leukemia, and HIV infection; however, it is important to investigate internal malignancies, not only hematologic malignancies but also solid cancers, when patients with RA under immunosuppressive therapies presented eruptive or disseminated molluscum contagiosums.
Assuntos
Artrite Reumatoide/patologia , Neoplasias Pulmonares/patologia , Molusco Contagioso/patologia , Idoso , Antirreumáticos/uso terapêutico , Artrite Reumatoide/complicações , Artrite Reumatoide/terapia , Feminino , Humanos , Hospedeiro Imunocomprometido , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/terapia , Metotrexato/uso terapêutico , Molusco Contagioso/complicações , Molusco Contagioso/terapia , PneumonectomiaRESUMO
Metastatic skin tumors present with a variety of clinical manifestations. We herein present two cases of metastases to the scalp, invading the skull, which showed epidermoid cyst-like appearances.