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1.
Ann Plast Surg ; 84(4): 413-417, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31800547

RESUMO

INTRODUCTION: Head and neck free flap (HNFF) reconstructions have historically utilized a multidisciplinary approach between otolaryngology head and neck surgery (OHNS) and plastic surgery (PS). However, there seems to be a trend toward both the extirpative and reconstructive portions being performed by OHNS. We aimed to elucidate the volume trend in HNFF reconstruction over the last decade. METHODS: Data were collected by 3 modalities: electronic medical record search of patients who underwent HNFF surgery at our institution (2013-2018), survey data from microsurgery fellowship programs (2007-2017), and National Surgical Quality Improvement Program (NSQIP) query of cases receiving designated HNFF Current Procedural Terminology codes (2011-2016). Data were analyzed with trends in HNFF reconstruction as our primary outcome. RESULTS: At our institution, HNFF reconstructions increased 4-fold (59-227). Percentage of cases by PS decreased from 18.6% to 6.0%, whereas that of OHNS increased 81.4% to 94.0% (P = 0.009). Survey data, completed by microsurgery fellowship program directors (23/81 [27.2%]), revealed the number of OHNS programs in 2007 performing 100 or more HNFF cases compared with PS was 40% (6/15) to 12.5% (1/8) (P = 0.172). By 2016, that number increased significantly for OHNS to 73.3% (11/15), whereas that of PS remained stagnant at 12.5% (1/8) (P = 0.005). According to NSQIP data, the percentage of cases performed by PS in 2011 was 52%, which was greater than OHNS's share of 43%. The other 5% was allotted to either orthopedic, oral and maxillofacial surgery, or general surgery. In 2013, those numbers reached a peak for PS at 55% and a nadir for OHNS at 36%. However, by 2016, the percentage of HNFF cases reversed. where 58% of cases were performed by OHNS and only 38% by PS. When comparing the 2011 data to the 2016 data, OHNS had a 134% increase, whereas PS had a 27% decrease (P = 0.003). CONCLUSIONS: Head and neck free flap reconstruction has grown dramatically over the last 10 years. Plastic surgeons are performing fewer cases, whereas otolaryngology head and neck surgeons perform more as indicated by institutional, microsurgery fellowship program director survey, and NSQIP data.


Assuntos
Retalhos de Tecido Biológico , Neoplasias de Cabeça e Pescoço , Otolaringologia , Procedimentos de Cirurgia Plástica , Cirurgia Plástica , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Microcirurgia
2.
J Reconstr Microsurg ; 35(9): 677-681, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31302904

RESUMO

BACKGROUND: Venous congestion in breast free flap reconstruction continues to be a major reason for flap compromise requiring reoperative exploration and possible flap failure. We aim to investigate whether size of the internal mammary vein (IMV) (1) varies between the left and right sides, (2) changes with certain patient demographics or preoperative factors, and (3) correlates with postoperative complications. METHODS: We performed a retrospective cohort study examining all patients undergoing free flap breast reconstruction from September 2005 to March 2016 using internal mammary recipient veins. Venous coupler size was used as a surrogate measure of IMV diameter. Preoperative patient characteristics and factors were collected. Postoperative outcomes assessed included thrombosis, flap loss, fat necrosis, and mastectomy flap necrosis. Multivariate analyses were performed to evaluate if preoperative factors affected IMV diameter and to determine if coupler size and flap side were independent risk factors for postoperative complications. RESULTS: We examined 372 patients with a total of 561 flaps. One hundred eighty-nine patients received bilateral flaps with the IMV as a recipient. The right IMV (n = 286, average = 2.97 mm, standard deviation [SD] = 0.41) was significantly larger than the left (n = 275, average = 2.89, SD = 0.35, p = 0.008). Preoperative factors and postoperative complications were not statistically different between the left and right cohorts. The multivariable linear regression model with coupler size as the dependent variable found older age trended toward a larger coupler size but this was not significant (p = 0.05). In multilinear regression analysis, the postoperative outcomes did not have significant covariates. CONCLUSION: We found that IMV size significantly differs between the right and the left sides. However, incidence of postoperative complications was not significantly different between the left and right sides, and the multivariate analyses did not identify flap side as an independent risk factor for adverse outcomes. Prospective studies evaluating actual IMV diameter and associated complications may potentially elucidate clinical significance.


Assuntos
Neoplasias da Mama/cirurgia , Mama/irrigação sanguínea , Retalhos de Tecido Biológico/irrigação sanguínea , Mamoplastia/métodos , Veias/anatomia & histologia , Veias/cirurgia , Feminino , Humanos , Hiperemia/prevenção & controle , Pessoa de Meia-Idade , Pennsylvania , Estudos Retrospectivos
3.
Plast Reconstr Surg ; 140(5S Advances in Breast Reconstruction): 69S-76S, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29064924

RESUMO

This article is a review of fat grafting for breast reconstruction. The use of small volume fat grafting for the correction of step-off deformities, intrinsic deformities, and extrinsic deformities of the breast, and the uses of large volume fat grafting for total breast reconstruction, correction of implant complications with simultaneous implant exchange with fat, and correction of noncancer chest wall deformities is reviewed. Cancer monitoring and the risks of cancer recurrence following fat-grafting to the breast is also reviewed.


Assuntos
Tecido Adiposo/transplante , Neoplasias da Mama/cirurgia , Mamoplastia/métodos , Implante Mamário/métodos , Feminino , Humanos , Retalhos Cirúrgicos , Transplante Autólogo
4.
J Plast Reconstr Aesthet Surg ; 70(5): 577-584, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28302367

RESUMO

PURPOSE: Although abdominal-based flaps remain the first choice for autologous breast reconstruction, alternative donor sites are necessary when the abdomen is unavailable. Abdominal donor site suitability is determined, at times, according to deep inferior epigastric perforator (DIEP)-protocol computed tomographic angiography (CTA) results. CTA provides information about the pelvis/upper thigh that can be used to evaluate the suitability of other donor sites. This study aimed to examine the utility of DIEP-protocol CTA in the assessment of a lateral thigh perforator (LTP) flap. Furthermore, a small clinical LTP flap breast reconstruction series was presented. METHODS: The LTP flap anatomy was studied in 100 DIEP-protocol CT angiographies (200 thighs). Collected data included lateral circumflex femoral artery (LCFA) origin; number, type, and course of LTPs; pedicle characteristics; and reference point measurements. Relative relationships between reference point anatomy and perforator anatomy were analyzed. RESULTS: Perforators originated from the LCFA ascending branch (4.6 mm average diameter), averaging 2.6 perforators/thigh. The mean estimated pedicle length was 7.7 cm (±0.7 cm). Septocutaneous perforators were present in 97% (1.8 perforators/thigh). Musculocutaneous perforators were present in 64% (0.9 perforators/thigh). The mean distance between anterior superior iliac spine and perforator was 9.9 cm (±1.5 cm). Perforators were located 0.13 cm (±1.1 cm) below the pubic symphysis. Our LTP flap clinical series featured dissection in the supine position and primary donor site closure and highlighted the difficulty in flap design (six patients, nine LTP flaps). CONCLUSIONS: LTPs are consistent, reliably present, and radiographically appear to be suitable for microsurgical transfer. DIEP-protocol CTA is an acceptable method for imaging the pertinent LTP anatomy.


Assuntos
Mamoplastia/métodos , Retalho Perfurante/irrigação sanguínea , Idoso , Aloenxertos/irrigação sanguínea , Aloenxertos/diagnóstico por imagem , Pontos de Referência Anatômicos , Angiografia por Tomografia Computadorizada , Feminino , Artéria Femoral/diagnóstico por imagem , Humanos , Microcirurgia/métodos , Pessoa de Meia-Idade , Coxa da Perna , Sítio Doador de Transplante/irrigação sanguínea
5.
Plast Reconstr Surg ; 137(6): 1793-1798, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26890509

RESUMO

BACKGROUND: Carpometacarpal arthroplasty provides well-documented pain relief with preservation of thenar function in basal joint arthritis treatment. Nevertheless, some patients continue to have pain following surgery. The authors hypothesize that unrecognized midcarpal (capitolunate) arthritis is a contributor to persistent pain after carpometacarpal arthroplasty. The prevalence of midcarpal arthritis in patients with basal joint arthritis is unknown. This article establishes the radiographic prevalence of midcarpal arthritis in patients with carpometacarpal arthritis. METHODS: Patients with basal joint arthritis were identified from a search using International Classification of Diseases, Ninth Revision code 716.94. Hand radiographs were reviewed and graded using the Eaton classification and Sodha classification for carpometacarpal arthritis. Scaphotrapeziotrapezoid arthritis and midcarpal arthritis were graded using the Sodha classification for arthritis as follows: grade 1, no or nearly no arthrosis; grade 2, definite arthrosis but not severe; and grade 3, severe arthrosis. RESULTS: Eight hundred ninety-six radiographs were reviewed. The prevalence of scaphotrapeziotrapezoid arthritis in this population was 64 percent. The prevalence of midcarpal arthritis in this population was 23.5 percent. The prevalence of midcarpal arthritis in patients with radiologic evidence of carpometacarpal arthritis was 25.4 percent. The prevalence of severe midcarpal arthritis was 7 percent. CONCLUSIONS: The prevalence of midcarpal arthritis in patients with basal joint arthritis is 24 percent. The presence of two locations of arthritis may explain persistent hand and wrist pain in this population despite carpometacarpal arthroplasty. Clinically, these data will allow hand surgeons to better educate patients with basal joint arthritis regarding the possibility of incomplete pain relief following carpometacarpal arthroplasty.


Assuntos
Artroplastia/métodos , Ossos do Carpo/cirurgia , Articulações Carpometacarpais/cirurgia , Osteoartrite/cirurgia , Osso Escafoide/cirurgia , Idoso , Ossos do Carpo/diagnóstico por imagem , Articulações Carpometacarpais/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite/diagnóstico , Radiografia , Estudos Retrospectivos , Osso Escafoide/diagnóstico por imagem
6.
Plast Reconstr Surg ; 137(1): 24e-30e, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26710058

RESUMO

BACKGROUND: Research demonstrates a link between obesity and increased circulating inflammatory cytokines, which lead to changes in the microvasculature. Massive weight loss patients often experience delayed wound healing after body-contouring procedures; however, no studies exist to explore the inflammatory response of massive weight loss on microvasculature. This study hypothesized that massive weight loss patients who undergo body-contouring procedures maintain persistently elevated inflammatory markers in the microvasculature that delay wound healing. METHODS: Superficial inferior epigastric artery vessels were harvested during abdominally based free flap surgery and abdominal contouring surgery for normal weight and massive weight loss patients, respectively. Vessels were histologically assessed using immunohistochemistry and trichome staining to assess and compare vessel architecture. Analysis was performed for intimal proliferation and luminal occlusion ratio. RESULTS: All patients (n = 23) were female. Quantitative analysis of immunohistochemistry stains revealed no difference between normal weight and massive weight loss patients. Trichrome staining demonstrated abnormal vessel architecture in the massive weight loss group. Intimal proliferation was 11.4 ± 4.8 percent for normal weight patients compared with 29.5 ± 4.9 percent for massive weight loss patients (p < 0.0001). Occlusion ratio for normal weight patients was 29.9 ± 3.9 percent compared with 46.2 ± 8.1 percent for massive weight loss patients (p < 0.0001) CONCLUSIONS:: Despite the return to normal levels of inflammatory markers after massive weight loss, trichrome staining demonstrated irregular composition in the tunica adventitia and tunica media and increased intimal proliferation and occlusion ratio. This suggests vasculopathy that could explain delayed wound healing in the massive weight loss population.


Assuntos
Abdominoplastia/métodos , Artérias Epigástricas/patologia , Microvasos/anormalidades , Redução de Peso , Adulto , Cirurgia Bariátrica/métodos , Biópsia por Agulha , Índice de Massa Corporal , Estudos de Casos e Controles , Artérias Epigástricas/cirurgia , Feminino , Seguimentos , Humanos , Imuno-Histoquímica , Microvasos/patologia , Pessoa de Meia-Idade , Obesidade Mórbida/cirurgia , Valores de Referência , Estudos Retrospectivos , Medição de Risco , Coleta de Tecidos e Órgãos , Resultado do Tratamento
7.
Ann Plast Surg ; 77(4): 420-4, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26418795

RESUMO

BACKGROUND: Velopharyngeal insufficiency affects as many as one in three patients after cleft palate repair. Correction using a posterior pharyngeal flap (PPF) has been shown to improve clinical speech symptomatology; however, PPFs can be complicated by hyponasality and obstructive sleep apnea. The goal of this study was to assess if speech outcomes revert after clinically indicated PPF takedown. METHODS: The cleft-craniofacial database of the Children's Hospital of Pittsburgh at the University of Pittsburgh Medical Center was retrospectively queried to identify patients with a diagnosis of velopharyngeal insufficiency treated with PPF who ultimately required takedown. Using the Pittsburgh Weighted Speech Score (PWSS), preoperative scores were compared to those after PPF takedown. Outcomes after 2 different methods of PPF takedown (PPF takedown alone or PPF takedown with conversion to Furlow palatoplasty) were stratified and cross-compared. RESULTS: A total of 64 patients underwent takedown of their PPF. Of these, 18 patients underwent PPF takedown alone, and 46 patients underwent PPF takedown with conversion to Furlow Palatoplasty. Patients averaged 12.43 (range, 3.0-22.0)(SD: 3.93) years of age at the time of PPF takedown, and 58% were men. Demographics between groups were not statistically different. The mean duration of follow-up after surgery was 38.09 (range, 1-104) (SD, 27.81) months. For patients undergoing PPF takedown alone, the mean preoperative and postoperative PWSS was 3.83 (range, 0.0-23.0) (SD, 6.13) and 4.11 (range, 0.0-23.0) (SD, 5.31), respectively (P = 0.89). The mean change in PWSS was 0.28 (range, -9.0 to 7.0) (SD, 4.3). For patients undergoing takedown of PPF with conversion to Furlow palatoplasty, the mean preoperative and postoperative PWSS was 6.37 (range, 0-26) (SD, 6.70) and 3.11 (range, 0.0-27.0) (SD, 4.14), respectively (P < 0.01). The mean change in PWSS was -3.26 (range, -23.0 to 4.0) (SD, 4.3). For all patients, the mean preoperative PWSS was 5.66 (range, 0.0-26) (SD, 6.60) and 3.39 (range, 0.0-27) (SD, 4.48), respectively (P < 0.05). The mean change in PWSS was -2.26 (range, -23.0 to 7) (SD, 5.7). There was no statistically significant regression in PWSS for either surgical intervention. Two patients in the PPF takedown alone cohort demonstrated deterioration in PWSS that warranted delayed conversion to Furlow palatoplasty. Approximately 90% of patients, who undergo clinically indicated PPF takedown alone, without conversion to Furlow Palatoplasty, will show no clinically significant reduction in speech. CONCLUSIONS: Although there is concern that PPF takedown may degrade speech, this study finds that surgical takedown of PPF, when clinically indicated, does not result in a clinically significant regression of speech.


Assuntos
Fissura Palatina/complicações , Faringe/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Distúrbios da Fala/cirurgia , Insuficiência Velofaríngea/cirurgia , Adolescente , Criança , Pré-Escolar , Fissura Palatina/cirurgia , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos , Fala , Distúrbios da Fala/etiologia , Resultado do Tratamento , Insuficiência Velofaríngea/etiologia , Adulto Jovem
8.
Clin Plast Surg ; 42(3): 289-300, vii, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26116934

RESUMO

Plastic surgeons have come to realize that fat grafting can rejuvenate an aging face by restoring or creating fullness. However, fat grafting does much more than simply add volume. Grafted fat can transform or repair the tissues into which it is placed. Historically, surgeons have hesitated to embrace the rejuvenating potential of fat grafting because of poor graft take, fat necrosis, and inconsistent outcomes. This article describes fat grafting techniques and practices to assist readers in successful harvesting, processing, and placement of fat for optimal graft retention and facial esthetic outcomes.


Assuntos
Tecido Adiposo/transplante , Face/cirurgia , Tecido Adiposo/irrigação sanguínea , Tecido Adiposo/fisiologia , Adulto , Técnicas Cosméticas , Feminino , Humanos , Lipectomia , Pessoa de Meia-Idade , Regeneração , Rejuvenescimento , Sucção , Transplante de Tecidos , Coleta de Tecidos e Órgãos , Transplante Autólogo
9.
Ann Plast Surg ; 73(4): 365-70, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23788142

RESUMO

BACKGROUND: While a cause and effect relationship is traditionally thought to exist between thigh surgery and postoperative lymphedema, the link between obesity-related lymphatic and/or venous disease and post-body contouring lower extremity edema has not been investigated. We hypothesize that patients who experience prolonged lower extremity edema following thigh surgery are predisposed to developing this complication due to unrecognized preoperative lymphovascular disease. METHODS: Fifty-five patients who had undergone body contouring surgery were identified from our prospective registry. Twenty-eight patients completed the Venous Clinical Severity Score (VCSS), a validated outcome measure of venous disease. Three time points were assessed: pre-weight loss (T1), post-weight loss but pre-body contouring (T2), and post-body contouring (T3). Based on T3 VCSS, patients were divided into 2 groups-a T3 VCSS ≤3 (group 1; N = 13) and a T3 VCSS ≥4 (group 2; N = 15). RESULTS: VCSS for group 1 at T1, T2, and T3 were 3.31 ± 0.55, 1.85 ± 0.27, and 1.54 ± 0.35 (mean ± SEM), respectively, versus 6.3 ± 1.10, 4.33 ± 0.8, and 6.8 ± 0.63 for group 2 (P < 0.05, P < 0.05, and P < 0.0001). Pain scores at T1 was 0.46 ± 0.21 for group 1 versus 1.1 ± 0.24 for group 2 (P < 0.05). Edema scores for group 1 at T1, T2, and T3 were 0.69 ± 0.29, 0.08 ± 0.08, and 0.15 ± 0.10 versus 1.87 ± 0.35, 1.13 ± 0.31, and 2.13 ± 0.24 for group 2 (P < 0.05, P < 0.001, and P < 0.0001, respectively). CONCLUSIONS: Using VCSS, post-bariatric patients with prolonged lower extremity edema experienced clinically identifiable signs of disease prior to weight loss and body contouring surgery. Thus, careful preoperative evaluation may help identify at-risk patients and aid in managing postoperative expectations.


Assuntos
Técnicas Cosméticas , Edema/etiologia , Linfedema/complicações , Obesidade/complicações , Complicações Pós-Operatórias/etiologia , Coxa da Perna/cirurgia , Insuficiência Venosa/complicações , Adulto , Feminino , Humanos , Extremidade Inferior , Linfedema/diagnóstico , Masculino , Pessoa de Meia-Idade , Obesidade/terapia , Avaliação de Resultados em Cuidados de Saúde , Período Pré-Operatório , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Insuficiência Venosa/diagnóstico , Redução de Peso
10.
Aesthet Surg J ; 32(8): 937-42, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23012659

RESUMO

BACKGROUND: Facial bone aging has recently been described as primarily resulting from volume loss and morphologic changes to the orbit, midface, and mandible. OBJECTIVE: The authors demonstrate how the facial skeleton bone mineral density (BMD) changes with age in both men and women and compare these changes to those of the axial skeleton. They also explore the aesthetic implications of such changes in bone density. METHODS: Dual-energy X-ray absorptiometry (DXA) scans of the facial bones and lumbar spine were obtained from 60 white subjects, 30 women and 30 men. There were 10 men and 10 women in each of 3 age categories: young (20-40 years), middle (41-60 years), and old (61+ years). The following measurements were obtained: lumbar spine BMD (average BMD of L1-L4 vertebrae), maxilla BMD (the average BMD of the right and left maxilla), and mandible BMD (the average BMD of the right and left mandibular ramus). RESULTS: The lumbar spine BMD decreased significantly for both sexes between the middle and old age groups. There was a significant decrease in the maxilla and mandible BMD for both sexes between the young and middle age groups. CONCLUSIONS: Our results suggest that the BMD of the face changes with age, similar to the axial skeleton. This change in BMD may contribute to the appearance of the aging face and potentially affect facial rejuvenation procedures.


Assuntos
Envelhecimento/patologia , Densidade Óssea , Técnicas Cosméticas , Ossos Faciais/patologia , Rejuvenescimento , Absorciometria de Fóton , Adulto , Fatores Etários , Idoso , Análise de Variância , Ossos Faciais/diagnóstico por imagem , Ossos Faciais/cirurgia , Feminino , Humanos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/patologia , Masculino , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Maxila/diagnóstico por imagem , Maxila/patologia , Pessoa de Meia-Idade , Fatores Sexuais , Adulto Jovem
11.
Plast Reconstr Surg ; 127(6): 2263-2269, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21617460

RESUMO

BACKGROUND: Capsular contracture remains a major problem following prosthetic breast implantation, especially in patients undergoing irradiation. Recent studies suggest that such radiation injuries are a cascading process of cytokine activation, with transforming growth factor (TGF)-ß acting as the "master switch." Because TGF-ß signals through phosphorylation of Smad3, a plausible approach to abate TGF-ß-induced capsular contracture would be to interrupt Smad3 signaling. To test this hypothesis, capsular contracture formation in wild-type and Smad3 knockout mice was compared using micro-computed tomographic and histologic examination. METHODS: On day 0, 48 mice were implanted with bilateral silicone gel implants. Postoperatively, animals were imaged using live-scan micro-computed tomographic scanning. Animals in the radiation arm then received a 10-Gy directed radiation dose. On postoperative days 21, 28, 35, and 42, animals were imaged again. Histologic evaluation was performed at necropsy. RESULTS: Irradiated implants in the wild-type mice demonstrated shape and contour deformation on micro-computed tomographic scanning beginning on postoperative day 21 and progressing through day 42. Conversely, micro-computed tomographic scanning of irradiated implants in knockout mice demonstrated few changes from day 0 through day 42. Corresponding histologic specimens from wild-type mice demonstrated irregular capsules composed of disorganized collagen that became thicker from day 21 to day 42. Irradiated knockout specimen maintained thin capsules from day 21 through day 42. CONCLUSIONS: In this work, inhibiting TGF-ß signaling led to a reduction in radiation-induced capsular contracture as measured by micro-computed tomographic and histologic evaluation. The results of this study suggest a promising target for the prevention of capsular contracture through the development of anti-Smad3/TGF-ß-based therapies.


Assuntos
Contratura Capsular em Implantes/metabolismo , Transdução de Sinais , Proteína Smad3/metabolismo , Fator de Crescimento Transformador beta/metabolismo , Animais , Contratura Capsular em Implantes/diagnóstico por imagem , Contratura Capsular em Implantes/patologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Géis de Silicone/efeitos da radiação , Microtomografia por Raio-X
12.
Plast Reconstr Surg ; 127(1): 374-383, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20871486

RESUMO

BACKGROUND: Facial aging is a dynamic process involving the aging of soft-tissue and bony structures. In this study, the authors demonstrate how the facial skeleton changes with age in both male and female subjects and what impact these structural changes may have on overall facial aesthetics. METHODS: Facial bone computed tomographic scans were obtained from 60 female and 60 male Caucasian subjects. Twenty male and 20 female subjects were placed in three age categories (20 to 40 years, 41 to 64 years, and 65 years and older). Each computed tomographic scan underwent three-dimensional reconstruction with volume rendering. Edentulous patients were excluded. The following measurements were obtained: upper face (orbital aperture area, orbital aperture width, and curvilinear analysis of the superior and inferior orbital rims), midface (glabellar angle, pyriform angle, maxillary angle, and pyriform aperture area), and lower face (bigonial width, ramus breadth, ramus height, mandibular body height, mandibular body length, and mandibular angle). RESULTS: The orbital aperture width and orbital aperture area increased significantly with age for both sexes. There was a significant increase in orbital aperture size (increase in height of the superomedial and inferolateral orbital rim) in both sexes. The glabellar and maxillary angles decreased significantly with age for both sexes, whereas the pyriform aperture area significantly increased for both sexes with age. Mandibular length and height both decreased significantly for each sex. The mandibular angle significantly increased with age for both sexes. CONCLUSIONS: These results suggest that the skeletal morphology of the face changes with age. This change in skeletal morphology may contribute to the appearance of the aging face.


Assuntos
Envelhecimento/fisiologia , Ossos Faciais/fisiologia , Adulto , Idoso , Estética , Ossos Faciais/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Rejuvenescimento/fisiologia , Tomografia Computadorizada por Raios X
13.
J Orthop Res ; 29(5): 684-93, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-20842701

RESUMO

Studies were performed evaluating the role of Smad3, a transcription factor mediating canonical TGF-ß signaling, on scarring and adhesion formation using an established flexor digitorum longus (FDL) tendon repair model. In unoperated animals the metatarsophalangeal (MTP) range of motion (ROM) was similar in Smad3(-/-) and wild-type (WT) mice while the basal tensile strength of Smad3(-/-) tendons was significantly (39%) lower than in WT controls. At 14 and 21 days following repair Smad3(-/-) MTP ROM reached approximately 50% of the basal level and was twice that observed in WT tendon repairs, consistent with reduced adhesion formation. Smad3(-/-) and WT maximal tensile repair strength on post-operative day 14 was similar. However, Smad3(-/-) tendon repairs maximal tensile strength on day 21 was 42% lower than observed in matched WT mice, mimicking the relative decrease in strength observed in Smad3(-/-) FDL tendons under basal conditions. Histology showed reduced "healing callus" in Smad3(-/-) tendons while quantitative PCR, in situ hybridization, and immunohistochemistry showed decreased col3a1 and col1a1 and increased MMP9 gene and protein expression in repaired Smad3(-/-) tendons. Thus, Smad3(-/-) mice have reduced collagen and increased MMP9 gene and protein expression and decreased scarring following tendon FDL tendon repair.


Assuntos
Cicatriz/fisiopatologia , Metaloproteinase 9 da Matriz/biossíntese , Proteína Smad3/deficiência , Traumatismos dos Tendões/fisiopatologia , Tendões/fisiologia , Aderências Teciduais/etiologia , Cicatrização/fisiologia , Animais , Cicatriz/etiologia , Ossos do Metatarso , Camundongos , Amplitude de Movimento Articular/fisiologia , Resistência à Tração/fisiologia , Fator de Crescimento Transformador beta1/fisiologia
14.
Plast Reconstr Surg ; 126(5): 1483-1491, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21042104

RESUMO

BACKGROUND: Capsular contracture remains one of the major problems following prosthetic implantation of the breast, especially in postmastectomy breast reconstruction patients receiving radiation therapy. Advances in this area have been hampered by the absence of an acceptable animal model. This study evaluates a new murine model with which to facilitate research into the cellular and molecular pathways underlying capsular contracture and provides a surrogate for evaluating potential therapies. METHODS: On day 0, mice were implanted with silicone gel implants. Postoperatively, animals were imaged using live-scan micro-computed tomography. Animals in the irradiation group then received a 10-Gy directed radiation dose from a slit-beam cesium source. On days 21, 28, 35, and 42, both irradiated and nonirradiated animals were imaged again and histologic evaluation was performed. RESULTS: Nonirradiated implants demonstrated little change in contour from day 0 through day 42 on micro-computed tomography, whereas irradiated implants demonstrated consistent shape deformation and irregularities in contour at these time points. Histologic evaluation showed that irradiated specimens developed thicker capsules and more disorganized capsules than nonirradiated specimens at each time point. CONCLUSIONS: In this article, the authors introduce a novel animal model with which to study capsular contracture. This model is the first of its kind to use radiation to induce, and live-scan micro-computed tomography to evaluate, capsular contracture. Radiation was shown to cause reproducible changes that can be consistently evaluated with micro-computed tomography and histology. Future studies with this model will study the cellular and molecular mechanisms underlying capsular contracture using knockout and transgenic mouse strains.


Assuntos
Implantes de Mama/efeitos adversos , Modelos Animais , Géis de Silicone , Animais , Camundongos , Camundongos Endogâmicos C57BL , Microrradiografia , Doses de Radiação , Tomografia Computadorizada por Raios X
16.
Plast Reconstr Surg ; 125(1): 332-342, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20048624

RESUMO

BACKGROUND: Facial aging is a dynamic process involving the aging of soft-tissue and bony structures. In this study, the authors demonstrate how specific bony aspects of the mandible change with age in both genders and what impact these structural changes may have on overall facial aesthetics. METHODS: Facial bone three-dimensional computed tomographic scans were obtained from 120 Caucasian subjects (60 women and 60 men). Our study population consisted of 20 male and 20 female subjects in each of three age categories (20 to 40, 41 to 64, and > or = 65 years). Edentulous patients were excluded. The following measurements were obtained: bigonial width, ramus breadth, ramus height, mandibular body height, mandibular body length, and mandibular angle. The data were analyzed with one-way analysis of variance and two-tailed t tests, with results considered significant at a value of p < 0.05. RESULTS: There was no significant change with regard to bigonial width or ramus breadth across age groups for either gender. Ramus height, mandibular body height, and mandibular body length decreased significantly with age for both genders, whereas the mandibular angle increased significantly for both genders with increasing age. CONCLUSIONS: These results suggest that the bony elements of the mandible change significantly with age for both genders and that these changes, coupled with soft-tissue changes, lead to the appearance of the aged lower third of the face.


Assuntos
Envelhecimento/fisiologia , Mandíbula/fisiologia , Adulto , Idoso , Cefalometria , Feminino , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Adulto Jovem
17.
Plast Reconstr Surg ; 124(3): 899-906, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19730310

RESUMO

BACKGROUND: The purpose of this study was to objectively report practices commonly used in cleft palate repair in the United States. This study investigates current surgical techniques, postoperative care, and complication rates for cleft palate repair surgery. METHODS: All 803 surgeon members of the American Cleft Palate-Craniofacial Association were sent online and/or paper surveys inquiring about their management of cleft palate patients. RESULTS: Three-hundred six surveys were received, a 38 percent response rate. This represented responses of surgeons from 100 percent of American Cleft Palate-Craniofacial Association registered cleft teams. Ninety-six percent of respondents perform a one-stage repair. Eighty-five percent of surgeons perform palate surgery when the patient is between 6 and 12 months of age. The most common one-stage repair techniques are the Bardach style (two flaps) with intravelar veloplasty and the Furlow palatoplasty. After surgery, 39 percent of surgeons discharge patients within 24 hours. Another 43 percent discharge patients within 48 hours. During postoperative management, 92 percent of respondents implement feeding restrictions. Eighty-five percent of physicians use arm restraints. Surgeons' self-reported complications rates are minimal: 54 percent report a fistula in less than 5 percent of cases. The reported need for secondary speech surgery varies widely. CONCLUSIONS: The majority of respondents repair clefts in one stage. The most frequently used repair techniques are the Furlow palatoplasty and the Bardach style with intravelar veloplasty. After surgery, the majority of surgeons discharge patients in 1 or 2 days, and nearly all surgeons implement feeding restrictions and the use of arm restraints. The varying feeding protocols are reviewed in this article.


Assuntos
Fissura Palatina/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Cuidados Pós-Operatórios/métodos , Coleta de Dados , Humanos , Lactente , Cuidados Pós-Operatórios/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Procedimentos de Cirurgia Plástica/efeitos adversos , Procedimentos de Cirurgia Plástica/estatística & dados numéricos , Estados Unidos
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