Assuntos
Neuromielite Óptica/diagnóstico por imagem , Medula Espinal/diagnóstico por imagem , Aquaporina 4/imunologia , Edema/diagnóstico por imagem , Incontinência Fecal/fisiopatologia , Feminino , Glucocorticoides/uso terapêutico , Humanos , Hipestesia/fisiopatologia , Fatores Imunológicos/uso terapêutico , Imageamento por Ressonância Magnética , Hemissuccinato de Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Mielite Transversa/líquido cefalorraquidiano , Mielite Transversa/diagnóstico por imagem , Neuromielite Óptica/líquido cefalorraquidiano , Neuromielite Óptica/fisiopatologia , Neuromielite Óptica/terapia , Paraparesia/fisiopatologia , Plasmaferese , Prednisona/uso terapêutico , Reflexo Anormal , Rituximab/uso terapêutico , Incontinência Urinária/fisiopatologiaRESUMO
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.