Prevalence and impact of human papillomavirus (HPV) in adults with cystic fibrosis: A self-reported cross-sectional Canadian survey.

BACKGROUND: In persons with cystic fibrosis (pwCF), little is known about the prevalence or impact of HPV on quality of life and attitudes towards vaccination. METHODS: We conducted a national online survey of adult pwCF. We sought to determine the prevalence of self-reported HPV infection, disease-associated complications and effects on quality of life. Additionally, we investigated factors associated with vaccination status. RESULTS: A total of 235 adult pwCF across Canada (≥18 years, 68% female) completed the survey. Forty-eight percent of female pwCF had a history of abnormal Pap smear, with 62% self-reporting a 'no' or 'low' chance of risk of HPV-associated disease. Across participants, 12% reported at least one HPV-associated complication including anogenital warts (58%), HPV-associated malignancies (34%) and cervical dysplasia requiring colposcopy (69%). Only 19% reported discussions with their CF care provider around HPV complications. Across both sexes, pwCF experienced high psychosocial burden in the domains of 'worries and concerns', 'sexual impact' and 'self-image'. Sixty percent of adult pwCF were unvaccinated for HPV. Eighty-one percent reported never having discussed HPV vaccination with their CF care provider, with similar rates in vaccinated and unvaccinated groups. Barriers to vaccination included: lack of discussions with healthcare providers (31%), insured coverage (based on age) (19%) and perceived side effects/risk (10%). CONCLUSIONS: Across adult pwCF, we found high prevalence of HPV disease and associated HPV-psychosocial burden and low vaccination uptake. Given the limited medical discussions reported, incorporation of HPV prevention and management should be prioritized by CF care providers as part of comprehensive multimodal care.

Aboard the Smile Train: Outcomes of Primary Cleft Palate Repair at a Tertiary Care Center: À bord du Smile Train : les résultats cliniques de réparations de fentes palatines dans un centre de soins tertiaires.

INTRODUCTION: Cleft palate repair is considered to be a safe procedure, yet still carries a 5% to 30% risk of complications. This study sought to assess the outcomes of this procedure in a high-burden Asian country that partners with the Smile Train to perform cleft surgeries. METHODS: The Aga Khan University medical records database was queried for pediatric patients undergoing cleft surgery between 2014 and 2017. Data were abstracted from the patient medical records, and details of the clinical, demographic factors, and postoperative outcomes were assessed. RESULTS: Among 142 patients with orofacial clefts, 102 (72%) underwent primary cleft palate repair, one-third (n = 36, 35%) of whom were operated as part of the Smile Train. The median preoperative hemoglobin was 11.4 g/dL (interquartile range: 10.7-12.0 g/dL), whereas the median weight was 8.3 kg (7.7-11.4 kg). Nearly two-thirds (n = 64, 63%) of the cohort underwent preoperative cardiology screening, with only a minority undergoing orthodontic treatment (n = 6, 6%). Approximately 15% (n = 15) of patients experienced a postoperative complication, most often a fistula (n = 11, 73%). On multivariable analysis, with each unit increase in hemoglobin levels, there was a 50% reduction in the odds of experiencing a complication (odds ratio: 0.51, 95% CI: 0.28-0.87). There were no in-patient deaths among the cohort. CONCLUSION: The results of the current study provide useful information to key stakeholders including patients, plastic surgeons, and policy makers on the outcomes of cleft palate repair in a developing country.

INTRODUCTION: La réparation des fentes palatines est considérée comme une intervention sécuritaire, mais comporte un risque de complications de 5 % à 30 %. La présente étude vise à évaluer les résultats de cette intervention dans un pays asiatique au fardeau élevé où les partenaires de Smile Train corrigent des fentes palatines. MÉTHODOLOGIE: Les chercheurs ont fouillé la base de données des dossiers de l'université Aga Khan pour en extraire les patients pédiatriques qui ont subi une intervention de fente palatine entre 2014 et 2017. Ils ont résumé les données des dossiers médicaux des patients et évalué le détail des facteurs cliniques et démographiques ainsi que les résultats postopératoires. RÉSULTATS: Sur les 142 patients ayant une fente labiopalatine, 102 (72 %) ont subi une réparation palatine primaire, dont le tiers a été opéré (n = 36, 35 %) par l'équipe de Smile Train. L'hémoglobine préopératoire médiane était de 11,4 g/dl (ratio interquartile de 10,7 à 12,0 g/dl), et le poids médian, de 8,3 kg (7,7 g à 11,4 kg). Près des deux tiers des membres de la cohorte (n = 64, 63 %) ont subi un dépistage préopératoire, et seule une minorité a suivi un traitement orthodontique (n = 6, 6 %). Environ 15 % des patients (n = 15) ont souffert d'une complication postopératoire, la plupart du temps sous forme de fistule (n = 11, 73 %). À l'analyse multivariée, à chaque nouvelle unité d'hémoglobine, le risque de complication diminuait de 50 % (rapport de cotes 0,51, IC à 95 %, 0,28 à 0,87). Aucun patient hospitalisé n'est décédé au sein de la cohorte. CONCLUSION: Les résultats de la présente étude fournissent de l'information utile aux principaux intervenants, y compris les patients, les plasticiens et les décideurs, sur les résultats des réparations de la fente palatine dans un pays industrialisé.

Treatment options for paediatric brainstem gliomas.

Paediatric brainstem gliomas (BSGs) can be classified broadly into two distinct categories: focal brainstem gliomas (FBSGs) and diffuse intrinsic pontine gliomas (DIPG). The former account for 20% of paediatric BSGs and are mostly indolent lesions with good prognosis. DIPGs constitute the remaining 80%, and are highly aggressive, malignant tumours having a dismal prognosis; being the foremost cause of death in children with brain tumours. Their poor response to treatment regimens is further complicated by their localization in eloquent brainstem areas, thereby making it difficult to establish a standardized framework of therapeutic intervention. In this review, the authors catalogue and appraise current treatment modalities utilized in the management of paediatric BSGs including steroid use, chemotherapy, radiotherapy, and surgery.

Pediatric Brainstem Gliomas: An Institutional Experience.

OBJECTIVE: The aim of this study was to analyze the clinical profiles and outcomes of pediatric brainstem gliomas treated at our institute. METHODOLOGY: We reviewed the files of 18 pediatric age group patients diagnosed with brainstem glioma at our institution. The following variables were recorded: age, sex, duration of symptoms, date of diagnosis, main clinical symptoms, Karnofsky performance status score, magnetic resonance imaging findings, histopathology findings, details of the treatment given, disease progression, and date of mortality/last follow-up. This data were then transferred to SPSS version 23 which was used for further analysis. RESULTS: The mean age of our cohort was 8.6 years (range 3-15). There were 11 (61.1%) males and 7 (38.9%) females. There were 16 (88.9%) patients with diffuse intrinsic pontine gliomas (DIPGs), 1 (5.6%) patients with exophytic medullary gliomas, and 1 (5.6%) patient with midbrain/tectal glioma. Mean overall survival (OS) was 9.7 months. Mean progression-free survival (PFS) was 6.3 months. All patients with DIPG eventually passed away from their disease. Patients with DIPG who received radiotherapy had a longer OS and PFS than those who did not (9.8 and 6 months vs. 3.4 and 2.4 months). Diagnostic latency >1 month was found to have a statistically significant longer progression-free interval. CONCLUSION: DIPGs in the pediatric population have a poor prognosis. Radiotherapy serves to increase survival time but is not curative.