Breast cancer: A comparative review for breast cancer detection using machine learning techniques.

Breast cancer is the most common cancer among women globally and presents a significant challenge due to its rising incidence and fatality rates. Factors such as cultural, socioeconomic, and educational barriers contribute to inadequate awareness and access to healthcare services, often leading to delayed diagnoses and poor patient outcomes. Furthermore, fostering a collaborative approach among healthcare providers, policymakers, and community leaders is crucial in addressing this critical women's health issue, reducing mortality rates, alleviating, and the overall burden of breast cancer. The main goal of this review is to explore various techniques of machine learning algorithms to examine high accuracy and early detection of breast cancer for the safe health of women.

Nanocarrier Based Delivery of Berberine: A Critical Review on Pharmaceutical and Preclinical Characteristics of the Bioactive.

Berberine (BBR) is an isoquinoline alkaloid with several therapeutic properties, including anti-microbial, anti-diarrhea, anti-viral, anti-inflammatory, antihypertensive, anti-tumor, and anti-diabetes. However, its low water solubility, low absorption, first-pass metabolism, nontargeting, and poor bioavailability represent major hurdles to its successful therapeutic applications. Hence, researchers have attempted to enhance the biological and pharmacological activity of BBR to overcome its drawbacks by encapsulation of BBR in micro and nano delivery systems. For the preparation of nanostructured carrier systems of BBR, a range of methods has been developed, and each method has its benefits and characteristics. This review critically describes different types of nanocarriers like liposomes, niosomes, ethosomes, nanoemulsions, polymeric nanoparticles, micelles, dendrimers, and silver and gold nanoparticles that have been used for encapsulation of BBR for different therapeutic applications. The various pharmaceutical characteristics (size, shape, entrapment efficiency, zeta potential, drug release, and drug permeation) of these BBR-loaded nanocarriers have been discussed systematically. Preclinical studies of BBR nanoformulations involving animal models are also discussed.