[State of insulin receptors and carbohydrate metabolism in children with diabetes mellitus]. / Sostoianie insulinovykh retseptorov i uglevodnogo obmena u detei, bol'nykh sakharnym diabetom.

Diabetes mellitus children demonstrate the lowering of insulin binding by lymphocytes on appearance of the signs of insulin overdosage. After standard breakfast preceded by insulin injection such patients show a lower blood content of ATP as compared to children without metabolic signs of insulin overdosage, which may be of importance in the pathogenesis of insulin resistance development. Patients with type I diabetes mellitus and hyperlactatemia manifested the lowering of glucose assimilation by lymphocytes whatever the presence of the signs of insulin overdosage, pointing to insulin resistance.

[Blood levels of glycosylated hemoglobin and ATP in diabetes mellitus in children]. / Glikolizirovannyi gemoglobin i ATF krovi pri sakharnom diabete u detei.

To elucidate possible role of alterations in levels of glycosylated hemoglobin and ATP of blood in pathogenesis of diabetic impairments, 29 children with insulin-dependent diabetes mellitus were studied. In these children the blood content of the glycosylated hemoglobin was distinctly increased simultaneously with a decrease in ATP level. The alterations were especially distinct in the children the parents of which suffered from ischemic heart disease, myocardial infarction, insult, hypertension, diabetes mellitus. Development of diabetes mellitus in these children was characterized by the most severe manifestations (especially frequent and severe diabetic lesions, distinct decreases in secretion of insulin and in efficiency of the hormone). A hypothesis is discussed on possible importance of accelerated glycosylation of proteins and of a decrease in ATP synthesis for development of diabetic lesions.

[Role of the liver in the regulation of blood levels of insulin, C-peptide and glucose]. / Rol' pecheni v reguliatsii urovnei insulina, C-peptida i gliukozy v krovi.

Insulin, C-peptide and glucose levels in the blood, collected from the portal, hepatic and femoral veins of 7 young healthy dogs were studied before and 3 to 45 minutes after intravenous glucose injection. It was found that insulin concentration in the peripheral vein does not reflect completely its secretion by pancreatic islets, since a considerable part of hormone, released after glucose injection, is retained by the liver. C-peptide concentration in the peripheral veins reflects more precisely the beta-cell secretory activity that insulin level. A rise of insulin concentration in the portal vein after intravenous glucose injection promotes the hepatic glucose assimilation.

[Effect of adenosine cyclic monophosphate on insulin secretion in healthy rats and in those with alloxan diabetes]. / Vliianie 3',5'-adenozinmonofosfata na sekretsiiu insulina u zdorovykh zhivotnykh i u zhivotnykh s alloksanovym diabetom.

Studies on rats and dogs demonstrated exogenous cAMP to aid elevation of the blood insulin level in healthy animals and, to a lesser extent, in the animals with a mild course of diabetes mellitus caused by alloxan damage of beta-cells. In case of a severe course of diabetes mellitus exogenous cAMP produced no stimulating action on the insulin secretion.