Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery.

Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT-conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor-alpha (TNF-α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

Endoscopic Transpapillary Gallbladder Drainage for Recurrent Cholecystitis after Covered Self-expandable Metal Stent Placement for Unresectable Malignant Biliary Obstruction.

A 76-year-old woman with advanced pancreatic cancer developed recurrent cholecystitis after covered self-expandable metal stent (CSEMS) placement. The cholecystitis was refractory to repeated percutaneous transhepatic gallbladder drainage (PTGBD). Cholecystography showed a patent cystic duct with right and cranial side bifurcation, which is indicative of an increased likelihood of success of endoscopic transpapillary gallbladder drainage (ETGBD). We were able to manage the cholecystitis by ETGBD without further recurrence. ETGBD is considered an effective internal drainage method for the management of acute cholecystitis after CSEMS placement, and its indication may be decided on the basis of the findings of cholecystography through the PTGBD route.

Hybrid epicardial ventricular tachycardia ablation with lateral thoracotomy in a patient with a history of left ventricular reconstruction surgery.

Although a hybrid procedure involving surgical access may be feasible for epicardial catheter ablation in individuals with prior cardiac surgery, surgical approaches in thoracotomy are important in patients with advanced adhesions. We performed an epicardial ventricular tachycardia (VT) ablation in a patient with dilated phase hypertrophic cardiomyopathy after left ventricular reconstruction. We gained surgical epicardial access via lateral thoracotomy based on the anticipated VT circuit in the apical anteroseptal area, which was estimated using prior endocardial mapping. The remaining epicardial myocardium around the surgical incision was involved in the central isthmus, and the VT was eliminated by radiofrequency catheter ablation. .

Acute Myocardial Infarction of the Left Main Coronary Artery Presenting with Cardiogenic Shock and Pulmonary Edema during Noncardiac Surgery.

Acute myocardial infarction (AMI) caused by severe stenosis of left main coronary artery (LMCA) presenting with cardiogenic shock and pulmonary edema during noncardiac surgery is uncommon, but a catastrophic event. A 77-year-old male with cholangiocarcinoma underwent hepatectomy. During the surgery, he presented with cardiogenic shock, which did not respond to infusion administration or vasopressor. A transesophageal echocardiogram revealed anterior, septal, and lateral severe hypokinesia and impaired left ventricular function. Emergent coronary angiogram showed severe stenosis of LMCA. The patient underwent primary percutaneous coronary intervention (PCI) under the support of intra-aortic balloon pump, followed by extracorporeal membrane oxygenation. The chest roentgenogram showed pulmonary edema. Two days after PCI, he successfully underwent hepatectomy and bile duct resection. Early identification of the cause of hemodynamic instability during noncardiac surgery and invasive strategy are important for minimizing the myocardial injury and improving clinical outcomes in AMI of LMCA.

Reversible Cancer Therapeutics-related Cardiac Dysfunction Complicating Intra-cardiac Thrombi.

Epirubicin-based chemotherapy carries a risk of inducing heart failure, although the frequency is rare. Bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody, has recently been widely used in patients with recurrent breast cancer as a first-line chemotherapeutic agent. Heart failure or arterial thromboembolism has been reported as a rare cardiovascular complication of bevacizumab. We herein report a breast cancer patient with reversible cancer therapeutics-related cardiac dysfunction associated with bevacizumab and epirubicin complicating intracardiac thrombi in the left atrium and left ventricle. This case underscores the importance of tailored medical planning according to the individual status in patients receiving anti-cancer therapies.

Use of a novel orbicularis oculi muscle overlap method for correction of tear-trough deformity.

BACKGROUND: Although the fat-pad-sliding method reported by Loeb and the "arcus marginalis release with preservation of orbital fat" method reported by Hamra are useful techniques for correcting tear trough deformity in the Asian population, including Japanese patients, occasional cases of tear-trough deformity have persisted even after surgery. To solve this problem, the authors developed a novel orbicularis oculi muscle overlap method, which has enabled them to obtain good results. METHODS: The orbicularis oculi muscle overlap method was performed for 10 patients (9 women and 1 man) with prominent tear-trough deformity. The average of these patients was 52 years (range, 34-72 years). The origin of the orbicularis oculi muscle was elevated at its adherence to the maxillary bone, and the innermost portion of the origin of the orbicularis oculi muscle was excised by a width of 6 to 7 mm to reduce the muscle tension. This muscle flap was overlapped relative to the orbital fat, which was repositioned over the orbital rim and sutured in place. RESULTS: Tear-trough deformity improved in all cases, and the patients were highly satisfied with their flat lower eyelids. CONCLUSION: The orbicularis oculi muscle overlap method is effective for thin eyelids with prominent tear-trough deformity. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

The versatile perifascial areolar tissue graft: adaptability to a variety of defects.

Reconstruction using flaps with good blood circulation is appropriate for covering an intractable ulcer or a fistula in which tendon or bones are exposed. A non-vascularised perifascial areolar tissue (PAT) graft can also survive in such an area. This study reports the versatile application of a PAT graft for use as a non-vascularised graft material. A total of 32 patients were treated between April 2004 and December 2010 (16 men and 16 women). The donor sites were the inguinal region in 20, the thigh in 11, and the subclavian region in one. There were 13 inlay grafts to the dead space after tumour resection, eight closures for cerebrospinal fluid leakage, seven skin ulcers with exposed bones and tendons, three fistulas, and one vascular leak of the common carotid artery. The total survival rate of the grafts was 91%. The complications associated with this procedure included infection in 9% and seroma in the donor site in 19%. However, all cases improved after conservative treatment. The PAT is a pliable loose areolar tissue with a rich vascular plexus, and the harvesting technique is quite simple and minimally invasive. The PAT graft could therefore represent an alternative for flaps that are used as a free graft material for the reconstruction of such defects as intractable skin ulcers, fistulas or dead spaces that usually require reconstruction with vascularised flaps.

Influence of mixing blood with calcium phosphate bone paste on hardening.

Calcium phosphate bone paste (CPP) has been recently introduced as a reconstructive material in craniofacial surgery. However, we observed that mixing of blood and CPP tended to interfere with CPP hardening. In addition, CPP mixed with blood tended to be absorbed postoperatively. Hence, we used a rabbit model and applied CPP mixed with blood over defects in the skull to investigate the influence of blood on CPP. Calcium phosphate bone paste was mixed with blood for 1 minute and applied to the defects in the calvarial bone of rabbits. At 4 and 24 postoperative weeks, we histologically evaluated morphologic changes in the hydroxyapatite (HA). Our study revealed that HA was not absorbed when a small quantity of blood (15%) was mixed with CPP. However, HA was absorbed almost entirely when a large quantity of blood (30%) was mixed with CPP. In addition, we found that the porosity of HA was increased by the mixture of a small quantity of blood into CPP, and this addition stimulated osteogenesis in HA.

Mandible reconstruction using the calcium-sulphate three-dimensional model and rubber stick: a new method, 'mould technique', for more accurate, efficient and simplified fabrication.

BACKGROUND: Osteocutaneous flaps are one of the best options for one-stage mandible reconstruction. However, the challenge remains to achieve optimal functional and cosmetic results. A new novel approach involving the preoperative prefabrication of a reconstructive plate through a calcium-sulphate three-dimensional (3D) model facilitates the contouring of vascularised bone grafts. We herein report our preparations and results using this technique. METHODS: A total of 17 mandibular defects were reconstructed by this novel approach. A calcium-sulphate 3D model was constructed from computed tomography (CT) data. After the oncologist designed the cut line on the model, the mandibular arc was ground to the neo-mandible shape, which consisted of several linear planes according to the osteotomy of the bone graft. The reconstruction plate was shaped to fit this. After tumour resection, the prefabricated plate was placed to the remaining mandible and revealed the defect to be reconstructed, just as a mould. Rubber sticks were used as a template to shape the bone graft. The preoperative information, and functional and aesthetic results were retrospectively analysed. RESULTS: As many as 12 fibular and 5 scapular flaps were applied. Postoperative complications included two salivary fistulae, one abscess and one partial skin loss, all of which were resolved after conservative treatment. Postoperatively, all patients could speak clearly, 12 had a normal diet and 12 had excellent cosmetic results. CONCLUSIONS: This is the first report using models made by calcium-sulphate. The largest advantage of this model is that the neo-mandible shape can be demonstrated preoperatively. The refinement of mandible reconstruction after tumour ablative surgery can be achieved with a prefabricated plate through the use of a calcium-sulphate 3D model. It enables more accurate, faster and simplified fabrication of reconstruction plates, thus leading to satisfactory functional and cosmetic results.

Cephalic index of Japanese children with normal brain development.

The cephalic index is a method of assessing skull morphology in craniosynostosis. There are known racial differences; however, there are few reports on this index in Japan. In this study, we investigated the cephalic indices of Japanese children with normal brain development using axial slice computed tomography. Children presented to our institution because of head injuries but received no particular diagnosis. One hundred four children with normal brain development (62 males and 42 females) were divided into 7 age categories, namely, 4 categories for those younger than 1 year and 3 categories for those between 1 and 3 years. The cephalic index was calculated according to the following equation: (cephalic width/cephalic length) × 100. The cephalic indices by age groups were as follows: 86.7, 0 to 3 months (n = 21); 87.5, 4 to 6 months (n = 9); 89.2, 7 to 9 months (n = 16); 86.3, 10 to 12 months (n = 9); 85.9, 1 year (n = 25); 86.3, 2 years (n = 15); and 83.7, 3 years (n = 9). In this study, the cephalic indices of Japanese children with normal brain development tended to be more brachycephalic than those of white children, as reported by Haas and Waitzman. Thus, we formulated the classification of current cephalic indices of children with normal brain development in Japan.

Clinical application of 320-row multidetector computed tomography for a dynamic three-dimensional vascular study: imaging findings and initial experience.

The 320-row multidetector computed tomography (MDCT) is now used by both cardiologists and neurosurgeons. It enables dynamic 3D-CT angiography, because the wide-area detector eliminates helical scanning, thus achieving very fast scanning times for single 3D-CT volume data. Some microvascular surgeons are familiar with 64-row MDCT for perforator studies, but there are few reports of studies using 320-row MDCT. This MDCT system was used to follow the dynamic blood flow of small vessels. It is considered to have a great potential in the clinical field of microvascular surgery.

Combined sliding flap using a single perforator enables simple closure of the donor site: a case report.

We report the case of a 39-year-old man with a dermatofibrosarcoma protuberans (DFSP) on the right shoulder. A wide surgical excision of the tumour was performed, creating a 12-cm-wide defect. An anterolateral thigh flap created from two semicircular skin paddles was harvested and the two skin paddles were slid towards each other to cover the circular defect. The sliding technique is a useful design that preserves the suprafascial plexus and enables a single perforator to supply two split-skin paddles. Using this design, the donor site can be closed primarily without requiring a skin graft. This technique can be applied to other free flaps to reconstruct wide defects after the resection of cancers.

Cranial expansion with distraction osteogenesis for multiple-suture synostosis in school-aged children.

Multiple-suture synostosis is a rare condition among patients with craniosynostosis. Their cranial shapes demonstrate various types depending on the fused sutures, and it tends to be less consistent in comparison to single-suture synostosis. The details regarding surgical intervention for multiple-suture synostosis have rarely been documented. This report presents 4 patients with nonsyndromic multiple-suture synostosis who were incidentally diagnosed as school-aged children. The age at the time of the surgery ranged from 7 to 11 years. All of the patients demonstrated digital printings on radiographs and an increased intracranial pressure. They underwent cranial expansion using the technique of distraction osteogenesis. In 3 patients, a pi osteotomy was performed; however, the osteotomized bone was not detached from the underlying dura. Four distraction devices were applied. In one patient, an occipital osteotomy was performed, and 2 distraction devices were applied. Distraction was completed in all patients, and the results of surgery were satisfactory. Large bony gaps are generally created by the conventional course of skull expansion. In older children, the bone defects are optimally treated by bone grafts. To harvest bone grafts, it is preferable to split the cranial bone. In this series, however, the calvarial bones were so thin that they could not be split. Therefore, the technique of distraction osteogenesis was used. Cranial distraction is a reliable and less invasive modality. In addition, it can allow for skull expansion without bone grafting in school-aged children.

A repositioning technique for nasal fracture using the little finger.

A nasal bone fracture is usually repositioned using either Walsham or Asch forceps. However, accurate repositioning is often difficult. We therefore performed a repositioning technique using the little finger in 10 patients with a new nasal fracture. The results were satisfactory in all of the patients. Although medical experts may consider our method to be primitive, we believe that our method is both safe and effective, because the operator can recognize both the fractured part and its actual condition using the little finger. With this method, the occurrence of unnecessary new fractures can be prevented, in addition to minimizing the degree of mucosal damage and the occurrence of nasal hemorrhage. Furthermore, we consider that this technique can also reduce the occurrence of postoperative deformities due to the reduced mucosal contracture with this treatment modality. Even if the use of an instrument is deemed necessary, such as in treating saddle-nose-type fractures, initially feeling the fracture with the little finger will still allow for a more precise fracture reduction. We therefore consider our method to be both safe and effective at the initial stage of diagnosis and for the treatment of patients presenting with nasal bone fractures.