RESUMO
Reinke oedema is a benign condition due to fluid collection within subepithelial space of the true vocal fold. This phenomenon is predisposed by chronic smoking, alcohol consumption and contribution of laryngopharyngeal reflux. Although benign, it may be life threatening when bilateral vocal folds are affected causing airway obstruction. In this report, awake tracheostomy was performed for a 65- year- old lady with stridor secondary to severe Reinke oedema. The importance of establishing a definitive airway is highlighted here in securing a difficult airway. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-023-03714-4.
Assuntos
Face/fisiopatologia , Rosácea/diagnóstico , Rosácea/tratamento farmacológico , Administração Oral , Antibacterianos/administração & dosagem , Tartarato de Brimonidina/administração & dosagem , Diagnóstico Diferencial , Doxiciclina/administração & dosagem , Feminino , Humanos , Inflamação , Pessoa de Meia-Idade , Singapura , Esteroides/administração & dosagem , Resultado do TratamentoRESUMO
Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of oncological conditions, including chronic myeloid leukemia and gastrointestinal stromal tumors. The most frequent dermatological side effect reported is pigmentary abnormalities. We report a case series of three Asian Chinese females with preexisting acquired dermal melanocytosis that progressed after initiation of imatinib treatment, and concurrently developed generalized hypopigmentation of the skin. All three patients had similar histological findings on skin biopsy. It is postulated that the KIT/SCF pathway has a central role in the pathogenetic mechanism. Therefore, it is important for physicians to be aware of this potential side effect of paradoxical pigmentation in patients treated with imatinib.
Assuntos
Antineoplásicos/efeitos adversos , Hipopigmentação/etiologia , Mesilato de Imatinib/efeitos adversos , Idoso , Antineoplásicos/uso terapêutico , Progressão da Doença , Feminino , Humanos , Mesilato de Imatinib/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Pessoa de Meia-Idade , Pele/patologiaRESUMO
Subungual squamous cell carcinoma is a rare entity and difficult to diagnose as its clinical presentation may resemble benign conditions. This case report highlights the need to maintain a high clinical index of suspicion, and recommends a practical approach for subungual conditions. Dermoscopy and a biopsy for histology are important adjuncts to clinch the diagnosis.