[The effect of non-invasive brain stimulation on neuroplasticity in the early recovery period after ischemic stroke]. / Vliyanie neinvazivnoi stimulyatsii golovnogo mozga na neiroplastichnost' v rannem vosstanovitel'nom periode ishemicheskogo insul'ta.

The post-stroke cognitive impairment syndrome (PSCI) develops in 10-80% cases of ischemic stroke and leads to a significant patients' quality of life impairment. The standard program of cognitive rehabilitation includes nootropic agents therapy and neuro-cognitive training. The additional various methods of non-invasive brain stimulation (NIBS) application can improve the results of PSCI rehabilitation. PURPOSE OF THE STUDY: Studying the different variants of NIBS influence on synaptic neuroplasticity in the early recovery period after ischemic stroke. MATERIAL AND METHODS: The rehabilitation of 62 patients with PSCI syndrome after ischemic stroke outcomes were studied. The patients were assigned to 5 groups. Patients from the control group underwent standardized nootropic therapy and course sessions with a neuropsychologist. The rest of the patients were divided into 4 groups, in which, in addition to the basic program of cognitive rehabilitation, different options for the course use of NIBS were used: photochromotherapy (PCT) with narrow-band optical radiation (NOR) with a wavelength of 530 nm (green light); rhythmic transcranial magnetic stimulation (rTMS) with a low-intensity high-frequency running pulsed magnetic field; infrared radiation with a wavelength of 1-56 microns, modulated by terahertz frequencies (IRMT); bioacoustic correction (BAC). We analyzed the dynamics of changes in scores of MMSE scales, FAB, Roshchina. In order to assess the effect of NIBS on neuroplasticity, the concentrations of BDNF and antibodies to the NR2 fragment of the NMDA receptor were evaluated before and after the completion of the rehabilitation course. RESULTS: Concentration values of antibodies to the NR2 subunit of the NMDA receptor in all groups remained consistently above the norm (more than 2 ng/ml) throughout the entire course of rehabilitation. Differences between groups in the dynamics of BDNF concentration in the peripheral blood were revealed. There was a significant (p<0.05) decrease in its concentration by almost 2 times by the end of rehabilitation course in control group. In the rTMS and IRMT groups, a decrease in the BDNF concentration was also recorded in dynamics, which, however, did not reach a significant level. There was no decrease in BDNF levels in the BAC group. There was an increase of this level in the PCT group. CONCLUSION: The use of different types of NIBS in the program of cognitive rehabilitation of patients with PSCI syndrome contributes to an increase in the rehabilitation potential due to the activation of neurotrophin-mediated synaptic neuroplasticity. Green light PCT and BAC have the greatest effect on increasing neuroplasticity after ischemic stroke.

[Use of ultra high-frequency electromagnetic fields in pediatric surgery]. / Primenenie sverkhvysokochastotnogo élektromagnitnogo polia v detskoi khirurgii.

The procedures associated with the application of a super-frequency electromagnetic field (SFEMF) are being introduced into a therapeutical process in their various modifications at the Pediatric Surgery Hospital of Russian State Medical University. This has been preceded by enormous experimental work aimed at evaluating the potentialities of SFEMF for potentiation of cryogenic exposure and for individual use for endovascular occlusion and local hyperthermia. A total of 947 patients were treated with SFEMF from 1979 to 1990. The largest group included children with hemangiomas of various site (n = 465) and those with cheloid scars (n = 395). Thirty-one patients underwent intravascular coagulation with SFEMF in the treatment of arterial and venous malformations and 31 patients were treated for pigmentary spots of various site with SFEMF + cryodestruction. Local hypothermia was performed in 25 children with extensive hemangiomas of the face and neck with SFEMF. The total therapeutical benefits reached 98%. For these purposes the authors used a Plot routine apparatus, 915 mHz, with a set of contact and special emitters. The experience with SFEMF in pediatric surgery suggests that it is highly effective and the trend is promising.