RESUMO
Peripheral blood cells from a female infant with Down syndrome and over 60% circulating myeloblasts were cultured in soft agar. Growth was virtually restricted to cluster formation, and cluster-forming cells resided almost exclusively in the very light density fraction (SG less than 1.062). Morphological assessment of clusters revealed no evidence of cellular differentiation beyond the blast cell stage. Despite receiving no specific chemotherapy, the peripheral blood normalized within 2 months, and there was no evidence of leukemia when the patient died aged 1 year from cardiac pathology. The findings indicate that caution should be exercised when assessing prognosis on the basis of in vitro growth characteristics in such patients.
Assuntos
Células Sanguíneas/crescimento & desenvolvimento , Síndrome de Down/sangue , Leucemia/sangue , Transtornos Mieloproliferativos/sangue , Ágar , Diferenciação Celular , Células Cultivadas , Síndrome de Down/complicações , Feminino , Humanos , Recém-Nascido , Transtornos Mieloproliferativos/complicaçõesRESUMO
Three patients are reported in whom treatment of Fanconi's anaemia with androgenic steroids was complicated by the development of either primary hepatocellular cancer (PHC) or peliosis hepatis. The first, a White woman aged 34 years, was found to have PHC after receiving first methyltestosterone and then oxymetholone for a total period of 7 years. She died 4 months after the diagnosis was made. The other 2 patients were White children who presented with peliosis hepatis after receiving methyltestosterone and oxymetholone for 8 years and oxymetholone for 5 years, respectively. Both died from their primary diseases shortly after oxymetholone treatment was discontinued. Possible pathogenic mechanisms involved in the development of these serious complications are discussed and the therapeutic dilemma raised by their occurrence is emphasised.
Assuntos
Carcinoma Hepatocelular/induzido quimicamente , Doença Hepática Induzida por Substâncias e Drogas , Neoplasias Hepáticas/induzido quimicamente , Oximetolona/efeitos adversos , Púrpura/induzido quimicamente , Adolescente , Adulto , Criança , Pré-Escolar , Anemia de Fanconi/tratamento farmacológico , Feminino , Humanos , Masculino , Oximetolona/uso terapêuticoRESUMO
Tests of iron and folate nutrition have been carried out in early pregnancy and at delivery in 63 Bantu females. Accepted normal values for serum iron, and percentage saturation of transferrin, but not for unsaturated iron-binding capacity, for non-pregnant subjects were found to apply equally well in pregnancy. Concomitant folate deficiency in early pregnancy did not render tests of iron deficiency less valid. The unsaturated iron-binding capacity, percentage saturation, and marrow iron stores in early pregnancy all showed a significant correlation with the haemoglobin value at term. Patients with normal marrow iron stores and a percentage saturation of transferrin of 20 or more at or before the 24th week are unlikely to become anaemic from iron deficiency during pregnancy.