RESUMO
Epilepsy is one of the most common neurologic disorders. The epileptic seizures as well as antiepileptic drugs may disturb the reproductive system function. Polycystic ovary syndrome occurs more commonly in women with epilepsy either treated or not with valproic acid. This article discusses the current knowledge about the relationships between epilepsy and polycystic ovary syndrome.
Assuntos
Epilepsia/epidemiologia , Síndrome do Ovário Policístico/epidemiologia , Saúde da Mulher , Causalidade , Comorbidade , Epilepsia/diagnóstico , Feminino , Humanos , Anamnese , Distúrbios Menstruais/epidemiologia , Oligomenorreia/epidemiologia , Síndrome do Ovário Policístico/diagnóstico , Gravidez , Fatores de RiscoRESUMO
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The psychiatric disorders accompanying the clinical symptoms and hormonal abnormalities are important, but underestimated, aspects in PCOS. Obesity, hirsutism, acne, menstrual disturbances and infertility play important roles in lowering the quality of life in women with PCOS. Depression and anxiety are more often observed in patients with PCOS than in healthy women. Some authors consider that there is a relationship between valproic acid treatment of bipolar disease and PCOS. There have been reports that in women with PCOS anorexia nervosa, bulimia nervosa and other unspecified eating disorders are found more often than in the general population.
Assuntos
Antimaníacos/efeitos adversos , Transtorno Bipolar/etiologia , Depressão/etiologia , Transtornos da Alimentação e da Ingestão de Alimentos/etiologia , Síndrome do Ovário Policístico/complicações , Ácido Valproico/efeitos adversos , Antimaníacos/administração & dosagem , Transtorno Bipolar/tratamento farmacológico , Feminino , Hirsutismo/complicações , Hormônios/sangue , Hormônios/metabolismo , Humanos , Distúrbios Menstruais/complicações , Obesidade/complicações , Qualidade de Vida , Ácido Valproico/administração & dosagemRESUMO
INTRODUCTION: The pathogenesis of PCOS has not been definitively determined and includes a number of genes linked with steroidogenesis, regulation of gonadotropin secretion, actions of insulin, obesity as well as chronic inflammatory processes. Some authors indicate that PPARgamma play a role in insulin sensitivity and are probably involved in hyperandrogenism in PCOS. The aim of the study was to assess the frequency of the Pro12Ala and Pro115Gln PPARgamma2 gene polymorphisms in women with PCOS. SUBJECTS AND METHODS: 54 PCOS women and 51 healthy women were recruited. Genetic studies to detect Pro12Ala and Pro115Gln PPARgamma2 gene polymorphism were performed. RESULTS: In the whole studied group the Pro115Gln polymorphism of the PPARgamma2 gene was not found. The frequency of the Pro12Ala polymorphism was estimated at 26.47% in the controls and at 23.15% in the PCOS patients. Women from the control and PCOS groups with BMI > or = 30 had statistically higher occurrence of the Ala allele than women with BMI <30 (38.80% versus 12.50% and 38.23% versus 18.75%). CONCLUSIONS: The frequency of the Pro12Ala polymorphism observed in the sample of women from the Lower Silesian population was significantly higher than in the majority of European populations.
Assuntos
PPAR gama/genética , Síndrome do Ovário Policístico/genética , Polimorfismo Genético/genética , População Branca/genética , Adulto , Feminino , Predisposição Genética para Doença/genética , Humanos , Reação em Cadeia da Polimerase , Valores de Referência , Saúde da Mulher , Adulto JovemRESUMO
INTRODUCTION: A body of evidence points to a familial aggregation of hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS). The aim of this study was to determine whether siblings of women with PCOS had evidence of hormonal abnormalities typical of PCOS. MATERIAL AND METHODS: Eighty-six siblings of women with PCOS (44 sisters, 42 brothers) were recruited. Two control groups consisted of 70 healthy women and 30 healthy men. Anthropometric, hormonal (testosterone, androstenedione, DHEA-S, LH, FSH) parameters and SHBG were assessed in all subjects. RESULTS: Mean testosterone and DHEA-S levels were higher in sisters of women with PCOS than in the control women. In eight of the 44 (18.2%) sisters, a diagnosis of PCOS was made. Mean testosterone and androstenedione levels, and free androgen index (FAI) were significantly higher in sisters with PCOS compared to the sisters without PCOS. Brothers of women with PCOS had higher DHEA-S level than the control men. Eleven of the 42 (26.2%) brothers had alopecia occurring before the age of 30. Prematurely balding brothers did not differ from the non-balding brothers in hormonal parameters. CONCLUSIONS: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent.