[Treatment results of patients with adenoid cystic carcinoma in the Otolaryngology Department at the University School of Medical Sciences in Poznan between 1958-1999]. / Wyniki lecznia chorych na raka gruczolowato--torbielowatego w Klinice Otolaryngologii AM w Poznaniu w latach 1958-1999.

In the years 1958-1999 the ENT Department at the University School of Medical Sciences in Poznan treated 125 patients suffering from adenoid cystic carcinoma located in the head and neck area. The aim of this study was to assess treatment results over a span of 41 years. The cases treated included 68 women and 57 men. The highest incidence of the disease was observed in men in their 70's--16 cases and women in their 50's--19 cases. In a majority of cases, the cancer started in major salivary glands, specifically parotid--51, submandibular--11, sublingual--4. Other places included minor salivary glands located in the palate--15, cheek--8, oral cavity--5 and tongue--4. Other glands affected by the tumor were those in the ethmoidomaxillary area--23. The treatment of choice was surgery with subsequent radiation. All patients were subjected to surgical treatment, 89 of them being subsequently radiated. Local recidivation was observed in 12 patients (i.e. 10%), metastases to neighbouring lymph nodes in 9 patients (i.e. 7%). Distant metastases affected the lungs--4 cases, liver--1 and bone--1.

[Latent otogenic cerebellar abscess]. / Usznopochodny ropien mózdzku o skrytym przebiegu klinicznym.

A case of latent otogenic cerebellar abscess is presented during chronic otitis media with cholesteatoma, in 42-year-old woman. Good results of the treatment were obtained by draining and substituting the content of abscess into antibiotic solution.

[Second primary malignant tumor in patients with nasopharyngeal cancer]. / Drugie pierwotne nowotwory zlosliwe u chorych na raka czesci nosowej gardla.

Clinical analysis of 90 patients with malignant nasopharyngeal tumors treated in 1985-1996 was performed. The real frequency of second tumors, immunity to second malignant tumor, therapy and genetical factors were described. Second malignant nasopharyngeal tumors occur rarely than in other head and neck tumors (in our material approx. 4%). An attention should be paid to the young age of our patients, mean 46 years.

[Development of second primary malignant neoplasms in patients treated for laryngeal cancer in the Otolaryngology Clinic of the University School of Medical Sciences in Poznan 1981-1999]. / Rozwój drugich pierwotnych nowotworów zlosliwych u chorych leczonych na raka krtani w Klinice Otolaryngologii Akademii Medycznej w Poznaniu w latach 1981-1999.

Second malignancies are the important cause shorting survival of patients with laryngeal cancer. We noted 51 patients with second malignant neoplasm after treatment for laryngeal cancer. The incidence of second neoplasms in lung, next in tonsils and the incidence of cancer of skin was the highest. Early detection of precancerous lesions would correct the prevention against second malignancies and by this way--correct the survival among patients with laryngeal cancer. The rate of incidence of the second primary tumors among patients after total laryngectomy with radiotherapy was 2.9%.

A comprehensive analysis of selected diagnostic methods with respect to their usefulness in evaluating the biology of neoplastic cells in patients with laryngeal cancer.

The difficult and complicated mechanism of cancer development with little knowledge about the biology of existing cancers can lead to a permanent search for new examination techniques to improve the precision of life expectancy in patients and the selection of the most efficient methods of treatment. The aim of this study was to analyze certain prognostic factors, i.e., p53, Ki67, proliferating cell nuclear antigen (PCNA), DNA ploidy and cell proliferating activity, as well as the degree of morphological differentiation and cell maturity evaluated on an ultrastructural level in patients with laryngeal cancers in connection with data obtained from follow-up examinations and the clinical course of the disease. Neoplastic tissue was taken from 120 patients with laryngeal cancers. All underwent surgical treatment, radiotherapy and combined treatment in the Department of Otolaryngology. Karol Marcinkowski University School of Medical Sciences, Poznan, Poland, and the Department of Otolaryngology-Head and Neck Surgery, Haukeland University, Bergen, Norway. Before beginning treatment all patients underwent histological verification of their neoplastic tissues. Histopathological examination proved that the majority of cases (95%) had a squamous cell carcinoma. The occurrence of changes within the lymph nodes of the neck (N) was significantly correlated with T, S, Ki67, metastases to lymph nodes, DNA ploidy, site and surgery performed. The degree of clinical progression (S) was intercorrelated with T, N, p53, Ki67, PCNA, DNA ploidy, site and laryngectomy. The occurrence of oncoprotein p53 in neoplastic cells was measured by the staining degree of their nuclei and was correlated with T, S, DNA ploidy, metastases to lymph nodes, PCNA and site. The degree of staining of neoplastic cells for the nuclear antigen Ki67 was correlated to T, N, G, S, DNA ploidy, metastases to lymph nodes and surgical treatment. The proliferative antigen PCNA in the examined population of patients was intercorrelated with T, p53, Ki67, metastases to lymph nodes and surgical treatment. The results obtained from DNA flow cytometry could be associated with N, G, p53, Ki67 and metastases to lymph nodes. On the basis of the results obtained, the techniques suggested for the morphological and biological evaluation of neoplastic cells in cancer of the larynx should include TNM classification + G + DNA + p53 + Ki67.

[Adenoid cystic carcinomas of the head and neck (cylindromas)]. / Raki gruczolowato-torbielowate glowy i szyi (oblaki).

In the years 1958-1997 111 patients with adenoid cystic carcinoma in the head and neck of different localization were treated at the Department of Otolaryngology--Head and Neck Surgery. Majority of the tumors originated of the major salivary glands, mainly in the parotid gland (47 cases). The most common location among the tumor of the minor salivary glands was the palate (14 persons). The tumors arising from other mucous glands, most frequently has located in the maxillo-ethmoideal complex (20 cases). The authors stress diagnostic difficulties, the necessity of a proper selection of the surgical method and postoperative radiotherapy, describing the treatment results in the patients. Radial surgical procedure of the adenoid cyctic carcinoma yelds optimal local control and survival rates.

[Pleomorphic adenomas in the materials of the Department of Otolaryngology of the Academy of Medical Sciences in Poznan]. / Gruczolaki wielopostaciowe w materiale Kliniki Otolaryngologii AM w Poznaniu.

In the years 1958-1997 were surgically treated in the Department of Otolaryngology Karol Marcinkowski University of Medical Sciences in Poznan 365 patients with pleomorphic adenomas. Majority of the tumors originated of the major salivary glands was parotid gland (273 cases). The given materials confirms the viewpoint that enucleation in the pleomorphic adenomas of the parotid salivary gland--based on total removal of the tumor together with the capsule and pouch constitute a completely sure surgical procedure.

[Craniofacial bone dysplasia]. / Osteodysplazja twarzoczaszki.

The case of fibrous dysplasia localised in the maxilla in 7 years old girl was described. Attention was paid to etiology, symptoms and treatment. The differential diagnosis was discussed. The diagnosis was wet set on the bases of clinical examination, X-ray, scyntygraphy and histological examination.

[Diagnostic problems in coexistence of paranasal sinusitis with cerebral tumor]. / Problemy diagnostyczne w przypadku zapalenia zatok przynosowych ze wspólistnieniem guza mózgu.

Differential diagnosis between the intracranial complications of paranasal sinusitis and cerebral tumor belongs to very difficult tasks in otolaryngology and neurosurgery. Complications of sinusitis, such as intracranial abscess formation, are uncommon and often clinically unremarkable. The arising difficulties are even greater in inflammatory intracranial complications of sinusitis, giving symptoms similar to those of cerebral tumors. The illustrative case report was presented.

[Osteomas of the paranasal sinuses in the Department of Otolaryngology of Karol Marcinkowski University of Medical Sciences in Poznan in 1959-1995]. / Kostniaki zatok przynosowych w materiale Kliniki Otolaryngologii AM w Poznaniu w latach 1959-1995.

In years 1959-1995 in the Department of Otolaryngology of University of Medical Sciences in Poznan 112 patients were treated for osteoma within paranasal sinuses. In our material there was 59 men and 52 women. The age range was 13 to 79. Quantitative analysis showed most cases of osteoma in frontal sinus, the second place was taken by ethmoidal cells and very rarely was osteoma observed in maxillary sinus and sphenoid sinus. Operation procedure was performed on all the patients.

[Results of surgical treatment of laryngeal cancer in elderly patients in 1946-95]. / Wyniki chirurgicznego leczenia raka krtani u osób w starszym wieku w latach 1946-1995.

In the years 1946-1995 in Karol Marcinkowski University School of Medical Sciences, Department of Otolaryngology, Head and Neck Surgery the long term results on 2223 patients with laryngeal cancer treated surgically according to the age were evaluated. Five year survival rates after total laryngectomy in elderly persons was 44.2%. Five year survival rates (67.7%) after partial laryngectomy justify their application in suitably chosen cases of cancer of the larynx.

[Acute fibromatosis from the standpoint of otolaryngology]. / Wlókniakowatosc agresywna w obrebie narzadów ORL.

Aggressive fibromatosis in the otolaryngological region is a curious clinical entity, demanding accurate histopathologic interpretation. It is rare connective tissue tumor, which growth infiltratively with a destructive biological behaviour similar to malignant tumours and a high recurrence rate. Morphologically reactive fibromatosis and fibrosarcoma should be considered amongst others in differential diagnosis. CT and MR scans are useful in determining the extent of the tumors and help to distinguish the tumor from nerves, vessels and bone. Surgery is the treatment of choice. Our observations of the course of disease in the maxillary sinus, nasal cavity and nasopharynx confirmed the date in literature.

[Adenoid cystic carcinoma in patients in the ENT Department of the K. Marcinkowski University of Medical Sciences in Poznan in years 1980-1995]. / Raki gruczolowato-torbielowate w materiale Kliniki Otolaryngologii Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu w latach 1980-1995.

In the years 1980-1995 60 patients with adenoid cystic carcinoma in the head and neck of different localization were treated at the Department of Otolaryngology. Majority of the tumors originated of the major salivary glands was parotid gland (24 cases). The most common location among the tumor of the minor salivary glands was the palate (5 cases). The tumors arising from others mucous glands, most frequently has located in the maxillo-etmoideal complex (12 cases). The authors stress diagnostic difficulties, the necessity of a proper selection of the surgical method and postoperative radiotherapy, describing the treatment results in the patients. Radical surgical procedure of the adenoid cystic carcinoma yields optimal local control and survival rates.

[Incidence of second primary malignant neoplasms in patients treated for laryngeal cancer]. / Wystepowanie drugich pierwotnych nowotworów zlosliwych u chorych leczonych z powodu raka krtani.

Although the survival rates reported for patients with laryngeal cancer are quite good, there is a risk of developing second malignant tumors in this population. From a total analyzed of 1268 patients with laryngeal cancer, the second malignant tumors in 30 persons group were identified. The prognosis for second malignant tumors is poor, especially with tumors of the lung and oesophagus. Vitamin A and carotenoids are promising for second malignancies prevention.

[Perioperative preventive use of ciprofloxacin in patients with cancer of the larynx]. / Profilaktyka okolooperacyjna z zastosowaniem ciprofloksacyny u chorych na raka krtani.

In comparative study of patients with laryngeal cancer, perioperative prophylaxis with ciprofloxacin was estimated. The drug was administered intravenously 200 mg twice daily, for five days to groups of 95 patients. Bacteriological examinations performed intraoperatively mostly revealed Gram-positive germs. The intravenous form of ciprofloxacin was very effective, resulting in complete healing of the operative wound in shorter time than in control groups. The drug has been well tolerated and no side effects were observed.

[Otogenic brain abscesses in children]. / Usznopochodne ropnie mózgowia u dzieci.

In the years 1953-1989 in the Department of Otolaryngology, Medical Academy in Poznan 75 patients were treated for otogenic brain abscesses, among them 19 were children. In the last ten years the number of cases of this complication was not increased significantly in children and adults. In 3 cases abscess was diagnosed in acute otitis media, in the remaining cases it was a complication of chronic otitis media with cholesteatoma. Brain abscesses were situated more frequently in the temporal lobe. In children they developed more frequently on the right side. The survival in temporal lobe abscesses in children was 90%, and in cerebellar abscesses 75%. In adults the survival rate was about 80% for both localizations. In the treatment of these otogenic complications wide radical operation on the middle ear or ++antro-mastoidectomy with exposure of the dura and simultaneous approach to the abscess from the postoperative ear cavity, with puncture of the abscess and replacement of its contents with normal saline with antibiotic is the routine method in the Department.

[Otogenic brain abscesses in a patient sample of the otolaryngology clinic of the Poznan Medical Academy 1953-1984]. / Otogene Hirnabszesse im Krankengut der Otolaryngologischen Klinik der Medizinischen Akademie in Poznan in den Jahren 1953-1984.

Between 1953-1984 we treated 64 otogenic brain abscesses (44 of the temporal lobe and 20 of the cerebellum). This material included 2 cerebral abscesses and 1 cerebellum abscess in children. In 3 cases the abscess was a complication of acute otitis media. 84% of patients with a temporal lobe abscess and 85% with a cerebellar abscess recovered. Treatment consisted of removal of the inflammatory process in the middle or inner ear with subsequent puncture of the abscess and replacement of the pus by antibiotic solution. Otologic, neurologic, ophthalmolgic, EEG and CT examinations were performed on 50 patients. Residual signs of epilepsy were found in 6 patients. Forty one patients resumed work or study. The merit of computer tomography (CT) in diagnosing brain abscesses is emphasized. Since CT has been used a successful outcome has been obtained in 8 cases and a fatal result in 1.