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Study objective: A multi-institutional interdisciplinary team was created to develop a research group focused on leveraging artificial intelligence and informatics for cardio-oncology patients. Cardio-oncology is an emerging medical field dedicated to prevention, screening, and management of adverse cardiovascular effects of cancer/ cancer therapies. Cardiovascular disease is a leading cause of death in cancer survivors. Cardiovascular risk in these patients is higher than in the general population. However, prediction and prevention of adverse cardiovascular events in individuals with a history of cancer/cancer treatment is challenging. Thus, establishing an interdisciplinary team to create cardiovascular risk stratification clinical decision aids for integration into electronic health records for oncology patients was considered crucial. Design/setting/participants: Core team members from the Medical College of Wisconsin (MCW), University of Wisconsin-Milwaukee (UWM), and Milwaukee School of Engineering (MSOE), and additional members from Cleveland Clinic, Mayo Clinic, and other institutions have joined forces to apply high-performance computing in cardio-oncology. Results: The team is comprised of clinicians and researchers from relevant complementary and synergistic fields relevant to this work. The team has built an epidemiological cohort of ~5000 cancer survivors that will serve as a database for interdisciplinary multi-institutional artificial intelligence projects. Conclusion: Lessons learned from establishing this team, as well as initial findings from the epidemiology cohort, are presented. Barriers have been broken down to form a multi-institutional interdisciplinary team for health informatics research in cardio-oncology. A database of cancer survivors has been created collaboratively by the team and provides initial insight into cardiovascular outcomes and comorbidities in this population.
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African Americans have a higher rate of cardiovascular morbidity and mortality and a lower rate of specialty consultation and treatment than Caucasians. These disparities also exist in the care and treatment of chemotherapy-related cardiovascular complications. African Americans suffer from cardiotoxicity at a higher rate than Caucasians and are underrepresented in clinical trials aimed at preventing cardiovascular injury associated with cancer therapies. To eliminate racial and ethnic disparities in the prevention of cardiotoxicity, an interdisciplinary and innovative approach will be required. Diverse forms of digital transformation leveraging health informatics have the potential to contribute to health equity if they are implemented carefully and thoughtfully in collaboration with minority communities. A learning healthcare system can serve as a model for developing, deploying, and disseminating interventions to minimize health inequities and maximize beneficial impact.
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BACKGROUND: The purpose of this study is to evaluate the outcome of revision total hip arthroplasty using an uncemented deep profile jumbo acetabular component in patients who had been followed for a minimum of 10 years postoperatively. METHODS: Between 1997 and 2001, 61 revision total hip arthroplasties were performed in 58 patients, with use of the +5 Deep Profile acetabular shell. The outcome with regard to retention vs re-revision of the acetabular component was determined for every hip. At a mean of 13 years (range 10-16) postoperatively, 30 patients (32 hips) were living. The Harris hip score, radiographic results, complications, and Kaplan-Meier survivorship were evaluated. RESULTS: In the entire cohort of 61 hips, 4 acetabular components have been re-revised. Two shells were re-revised for sepsis: 1 shell was re-revised for aseptic loosening and 1 for recurrent dislocation. In the 32 hips followed for a minimum of 10 years postoperatively, 2 cups have been re-revised: 1 for aseptic loosening and 1 for recurrent dislocation. One additional shell was loose by radiographic criteria. With failure defined as re-revision for any reason, implant survival (95% confidence interval) was 92.6% (81.0-97.2) at 16 years. With failure defined as re-revision for aseptic loosening, implant survival was 97.4% (82.8-99.6) at 16 years. CONCLUSION: Revision total hip arthroplasty with the +5 Deep Profile acetabular component was associated with a good rate of survival at 16 years.
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Acetábulo/cirurgia , Artroplastia de Quadril , Prótese de Quadril , Luxações Articulares/cirurgia , Reoperação , Adulto , Idoso , Artroplastia de Quadril/efeitos adversos , Feminino , Seguimentos , Prótese de Quadril/efeitos adversos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Desenho de Prótese , Falha de Prótese , Reoperação/efeitos adversos , Sepse/cirurgia , Resultado do TratamentoRESUMO
BACKGROUND: Previously, we reported the mean 16-year results of primary uncemented total hip arthroplasty using a tapered femoral component in patients <50 years. The purpose of this study was to update our previous report using the Taperloc femoral component in young patients who had been followed for a minimum of 20 years postoperatively. METHODS: Between 1983 and 1990, 108 consecutive uncemented total hip arthroplasties were performed in 91 patients of age <50 years, with use of the Taperloc femoral component. Every patient was followed for a minimum of 20 years after surgery or until death. At a mean of 25 (range, 20-29 years) postoperatively, 76 patients (91 hips) were living. The Harris Hip Score, radiographic results, complications, and Kaplan-Meier survivorship were evaluated. RESULTS: In the entire cohort of 108 hips, 9 femoral components (8%) have been revised, none for aseptic loosening. Five well-fixed stems were removed during acetabular revision, 3 stems were revised for infection, and 1 stem was exchanged because of a peroneal nerve palsy. Distal femoral osteolysis was identified around 1 hip. With failure defined as stem removal for any reason, implant survival was 90% (CI = 82-95) at 29 years. With failure defined as stem removal for aseptic loosening, implant survival was 100% at 29 years. CONCLUSION: Primary total hip arthroplasty with the Taperloc femoral component in young patients was associated with a high rate of survival at 29 years.
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Acetábulo/cirurgia , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Fêmur/cirurgia , Prótese de Quadril , Adulto , Idoso , Doenças Ósseas/mortalidade , Doenças Ósseas/cirurgia , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Desenho de Prótese , Falha de Prótese , Reoperação , Taxa de Sobrevida , Resultado do TratamentoRESUMO
A cementless femoral component may allow for a smaller surgical incision when a minimally invasive approach is used during primary total knee arthroplasty. Fixation by cement is the gold standard for total knee arthroplasty. The results of cementless total knee arthroplasty are mixed. Cementless femoral components have done well. Although some tibial components have performed well at long-term follow-up, others have been plagued by high rates of loosening and revision. The question remains whether the results of hybrid total knee arthroplasty, consisting of an uncemented femoral component and a cemented tibial component, will equal those of total knee replacement fixed with cement at long-term follow-up. The authors reviewed 148 hybrid total knee arthroplasties performed by a single surgeon between 1993 and 1995. At a mean follow-up of 14 years (range, 10-16) 5 knees (4%) had undergone revision of both the femoral and tibial components. Only 1 knee required revision for aseptic loosening. Two knees were revised for sepsis; 1 knee had been revised for fracture and 1 for instability. No additional femoral or tibial components were loose by radiographic criteria. Mild focal femoral osteolysis was identified in 3 knees (2%), and minor tibial osteolysis was present in 2 knees (1%). The rate of survivorship with revision for aseptic loosening as the end point was 99% (95% confidence interval, 0.97-100) at 16 years for both the femoral and tibial components. In this series, hybrid total knee arthroplasty showed excellent fixation at 16 years.
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Artroplastia do Joelho/estatística & dados numéricos , Articulação do Joelho/diagnóstico por imagem , Artroplastia do Joelho/métodos , Cimentos Ósseos , Seguimentos , Humanos , Desenho de Prótese , Falha de Prótese , Radiografia , Reoperação , Resultado do TratamentoRESUMO
The purpose of the present study was to evaluate the outcome of primary uncemented total hip arthroplasty in patients younger than 50 years using the Taperloc (Biomet, Warsaw, Ind) femoral component. We evaluated 94 hips in 79 patients at a mean follow-up of 16 years (range, 11-18.5 years). The average age of the patients at the time of surgery was 36 years (range, 20-49 years). Three femoral components had been revised, none for aseptic loosening. Complete clinical and radiographic follow-up was obtained on the 91 hips that had not undergone femoral component revision. The mean Harris hip score increased from 54 points (range, 20-72) before surgery to 93 points (range, 68-100) at the time of this review. Radiographically, 89 stems (98%) were determined to have fixation by bone ingrowth, 2 (2%) demonstrated stable fibrous ingrowth, and no femoral component was loose. Distal femoral osteolysis was identified in 1 hip (1%). These findings indicate that excellent clinical and radiographic results can be achieved in young patients with the Taperloc femoral component at a mean follow-up of 16 years.
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Artroplastia de Quadril/instrumentação , Fêmur/diagnóstico por imagem , Prótese de Quadril/normas , Osteoartrite do Quadril/cirurgia , Desenho de Prótese/normas , Adulto , Artrite Reumatoide/cirurgia , Feminino , Fêmur/cirurgia , Necrose da Cabeça do Fêmur/cirurgia , Seguimentos , Luxação Congênita de Quadril/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Resultado do TratamentoRESUMO
The goal of this study was to evaluate the outcome at a mean follow-up of 24.5 years (range, 22-26 years) of a consecutive series of 138 patients (145 hips) treated with total hip arthroplasty (THA) with the use of the Taperloc femoral component (Biomet, Warsaw, Indiana). This was an FDA-approved prospective study. All surgeries were performed by a single surgeon. Each of the 138 patients (145 hips) was followed annually until death, femoral component revision, or a minimum of 22 years. Complete clinical and radiographic follow-up was obtained on 95% of living patients at 5 years, and 100% at 10, 15, 20, and 24.5 years. Of the original series of 145 hips, only 1 femoral component (0.7%) had undergone revision for aseptic loosening, and 1 was loose by radiographic criteria (0.7%). Femoral osteolysis was identified in 8 hips (5.5%). A subset of 63 THAs in 56 patients was followed for a mean of 24.5 years. In this group, no femoral component required revision for aseptic loosening, and 1 was loose by radiographic criteria. Femoral osteolysis was present in 4 hips. Survivorship analysis of the femoral component with revision for aseptic loosening as the endpoint was 99% (95% confidence interval, 0.97-100) at 26 years. This stem demonstrates excellent fixation at a follow-up of 24.5 years with no apparent deterioration of the results with time.
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Artroplastia de Quadril/instrumentação , Prótese de Quadril , Seguimentos , Humanos , Osteólise/epidemiologia , Estudos Prospectivos , Desenho de Prótese , Reoperação/estatística & dados numéricosRESUMO
BACKGROUND: Excellent intermediate-term results with use of tapered femoral components in primary total hip arthroplasty have been reported. The purpose of this study was to update our previous report and to evaluate the outcome of total hip arthroplasty with use of the porous Taperloc femoral component in patients who had been followed for a minimum of eighteen years postoperatively. METHODS: One hundred and forty-five consecutive uncemented total hip arthroplasties in 138 patients were performed between 1983 and 1985, by a single surgeon, with use of the Taperloc femoral component. The outcome of every femoral component with regard to stem fixation, retention, or revision was determined for all 145 total hip replacements. At a mean of twenty years (range, eighteen to 22.6 years) postoperatively, fifty-eight patients (sixty-five hips) were living. In fifty living patients (fifty-seven hips), the femoral component had not undergone revision surgery. Evaluation of the living patients included clinical and radiographic analysis and recording of complications. RESULTS: Of the eighty patients (eighty hips) who had died, five hips had undergone revision of the femoral component. Only one stem had been revised for aseptic loosening, and no femoral component had been definitely loose by radiographic criteria. In the remaining sixty-five hips in the fifty-eight living patients, eight femoral components were revised. No femoral component underwent revision for aseptic loosening. Definite radiographic evidence of femoral component loosening occurred in one hip. In the fifty living patients (fifty-seven hips) who had not undergone femoral component revision, there was a significant improvement in the mean Harris hip score from 49.3 points preoperatively to 85.4 points at the time of latest follow-up (p = 0.001). Survivorship analysis of all 145 hips, with revision for any reason as the end point, estimated that the survival rate for the femoral component was 87% (95% confidence interval, 79% to 93%) at twenty-two years. CONCLUSIONS: Primary total hip arthroplasty with the Taperloc femoral component is associated with a low rate of aseptic loosening at a mean follow-up of twenty years.