Concordance of Dye-Spraying Chromoendoscopy and Virtual Chromoendoscopy for Colonic Dysplasia Detection in Longstanding Inflammatory Bowel Disease.

BACKGROUND/AIMS: In the past, dye-spraying chromoendoscopy was the technique of choice for colonic surveillance in patients with long-standing extensive inflammatory bowel disease. Recent evidence suggests that virtual chromoendoscopy is an equally acceptable technique. MATERIALS AND METHODS: Eleven gastroenterologists were given a survey with 20 pairs of pictures from inflammatory bowel disease surveillance colonoscopies (10 with nondysplastic lesions, 5 with dysplastic lesions, and 5 with no lesions). Each pair contained the same image captured during colonoscopy using indigo carmine and narrow-band imaging. For each picture, the gastroenterologist assessed the presence/absence of lesion and, when a lesion was identified, assessed the presence/absence of dysplasia and delineated its margins. To compare lesion and dysplasia detection between techniques, sensitivity, specificity, and interobserver agreement were calculated. The chi-square test was used to assess the accuracy of margins delineation. RESULTS: When assessing lesion and dysplasia detection, similar sensitivity and specificity values were obtained for both techniques. Interobserver agreement analysis revealed that dye-spraying chromoendoscopy and virtual chromoendoscopy had a moderate agreement in lesion detection but, for dysplasia detection, dye-spraying chromoendoscopy had a slight agreement [K = 0.11 (0.03-0.18), P < .01] and virtual chromoendoscopy a fair agreement [K = 0.30 (0.22-0.37), P < .01]. Margin delineation was similar between techniques. CONCLUSION: Sensitivity and specificity for lesion and dysplasia detection, as well as the accuracy of margins delineation, were similar between dye-spraying chromoendoscopy and virtual chromoendoscopy. Interobserver agreement for dysplasia detection was suboptimal in both techniques; however, it was superior when using virtual chromoendoscopy. These findings suggest that virtual chromoendoscopy constitutes a valid alternative for dysplasia screening in inflammatory bowel disease.

HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE.

BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes. Several biological properties, such as anti-inflammatory, anticancer, antitumor, hepatoprotective and low toxicity, are reported for this plant. OBJECTIVE: This study investigated hepatoprotective activity and the antioxidant effect of methanolic extract of I. suffruticosa leaves (MEIS) on Swiss albino mice submitted to experimental models of acetaminophen-induced liver injury. METHODS: MEIS (50 mg/kg; p.o.) was standardized according to the LD50 and its hepatoprotective property on Swiss albino mice evaluated during a 7-day period. On the eighth day, the acetaminophen-induced hepatic injury was performed. Histomorphometric analysis of liver tissue, antioxidant activity and serum levels of alanine aminotransferase (AST), aspartate aminotransferase (ALT) and bilirubin were measured. RESULTS: MEIS (50 mg/kg; p.o.) restored serum enzyme levels and results were close to those of positive control (silymarin) when compared to the negative control. Histopathological and histomorphometric analyzes confirmed MEIS hepatoprotective activity, showing reorganization of structural units of cells, nuclei and sinusoidal capillaries of hepatocytes, reducing the damage on liver tissue and increasing organ regeneration rate. MEIS showed high antioxidant potential at concentrations of 1000 and 500 µg/mL. CONCLUSION: This study suggests that MEIS has hepatoprotective activity and high antioxidant potential.

Eficácia hepatoprotetora do extrato metanólico de Indigofera suffruticosa (Mill) em lesão hepática induzido por paracetamol em camundongos / Hepatoprotective efficacy of methanolic extract of indigofera suffruticosa (mill) on paracetamol-induced liver damage in mice

ABSTRACT BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes. Several biological properties, such as anti-inflammatory, anticancer, antitumor, hepatoprotective and low toxicity, are reported for this plant. OBJECTIVE: This study investigated hepatoprotective activity and the antioxidant effect of methanolic extract of I. suffruticosa leaves (MEIS) on Swiss albino mice submitted to experimental models of acetaminophen-induced liver injury. METHODS: MEIS (50 mg/kg; p.o.) was standardized according to the LD50 and its hepatoprotective property on Swiss albino mice evaluated during a 7-day period. On the eighth day, the acetaminophen-induced hepatic injury was performed. Histomorphometric analysis of liver tissue, antioxidant activity and serum levels of alanine aminotransferase (AST), aspartate aminotransferase (ALT) and bilirubin were measured. RESULTS: MEIS (50 mg/kg; p.o.) restored serum enzyme levels and results were close to those of positive control (silymarin) when compared to the negative control. Histopathological and histomorphometric analyzes confirmed MEIS hepatoprotective activity, showing reorganization of structural units of cells, nuclei and sinusoidal capillaries of hepatocytes, reducing the damage on liver tissue and increasing organ regeneration rate. MEIS showed high antioxidant potential at concentrations of 1000 and 500 µg/mL. CONCLUSION: This study suggests that MEIS has hepatoprotective activity and high antioxidant potential.

RESUMO CONTEXTO: Indigofera suffruticosa Mill (Fabaceae) é abundante no nordeste do Brasil e popularmente utilizada no tratamento de processos infecciosos e inflamatórios. Várias propriedades biológicas, como anti-inflamatório, anticâncer, antitumoral, hepatoprotetor e baixa toxicidade, são relatadas para esta planta. OBJETIVO: Este estudo investigou a atividade hepatoprotetora e o efeito antioxidante do extrato metanólico de folhas de I. suffruticosa (MEIS) em camundongos albinos suíços submetidos a modelos experimentais de lesão hepática induzida por paracetamol. MÉTODOS: O MEIS na dose de 50 mg/kg (via oral) foi padronizado de acordo com a LD50 e sua propriedade hepatoprotetora em camundongos albinos Swiss avaliados durante um período de sete dias. No oitavo dia, a lesão hepática foi induzida por paracetamol em todos grupos pre-tratados. Foram medidos os níveis sericos enzimaticos, alanina aminotransferase, aspartato aminotransferase e bilirrubina, análise histomorfométrica do tecido hepático e atividade antioxidante. RESULTADOS: O MEIS restaurou os níveis séricos de enzimas e os resultados foram próximos aos do controle positivo (silimarina) quando comparados ao controle negativo. As análises histopatológicas e histomorfométricas confirmaram a atividade hepatoprotetora do MEIS, mostrando reorganização das unidades estruturais das células, núcleos e capilares sinusoidais dos hepatócitos, reduzindo os danos no tecido hepático e aumentando a taxa de regeneração de órgãos. O MEIS apresentou alto potencial antioxidante nas concentrações de 1000 e 500 µg/mL. CONCLUSÃO: Este estudo sugere que I. suffruticosa tem atividade hepatoprotetora e alto potencial antioxidante.

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a clonal entity defined by distinct functional properties and transcriptomic profiles, but rather a plastic state that most cancer cells can adopt. We show that phenotypic heterogeneity arises from non-hierarchical, reversible state transitions, instructed by the microenvironment and is predictable by mathematical modeling. Although functional stem cell properties were similar in vitro, accelerated reconstitution of heterogeneity provides a growth advantage in vivo, suggesting that tumorigenic potential is linked to intrinsic plasticity rather than CSC multipotency. The capacity of any given cancer cell to reconstitute tumor heterogeneity cautions against therapies targeting CSC-associated membrane epitopes. Instead inherent cancer cell plasticity emerges as a novel relevant target for treatment.

Freud e os desdobramentos da questão histérica na história de Christoph Haizmann / Freud and the developments of the hysterical issue in Christoph Haizmann's case / Freud et les développements de la question hystérique dans le cas de Christoph Haizmann / Freud y el desarrollo de la cuestión de la histeria en la historia de Christoph Haizmann

O trabalho visa, inicialmente, delinear algumas referências históricas sobre o tema da histeria, especialmente em sua perspectiva demológica e as "teorias" que articulam a ideia do demônio às "doenças da alma". A seguir resgata-se o artigo freudiano "Uma neurose demoníaca do século XVII", de 1923, quando Freud, a partir de seu interesse pela feitiçaria, possessões e fenômenos afins, dedica-se ao estudo do caso do pintor Christoph Haizmann que, acossado por convulsões e alucinações assustadoras, faz um pacto com o diabo. No referido trabalho, Freud estabelece as relações entre a figura do demônio e a figura paterna destacando uma questão fundamental para o estudo da histeria que servirá para as posteriores elaborações de Lacan sobre o tema.

Initially, this paper aims to outline some historical references about hysteria, especially from its demonological perspective and regarding the "theories" which associate the idea of 'demon' to 'illnesses of the soul'. We take into account Freud's paper 'A seventeenth-century demonological neurosis' (1923), written in a time when Freud examined witchcraft, possessions and other phenomena and analyzed Christoph Haizmann's case who, harassed by convulsions and frightening hallucinations, makes a deal with the devil. In that paper, Freud associates the figure of the demon to the figure of the father, outlining a fundamental question for the studies on hysteria, which will serve for Lacan's developments about that subject.

Cet article vise initialement à délimiter certaines références historiques concernant le thème de l'hystérie, notamment en ce qui concerne sa perspective démonologique et les 'théories' qui lient l'idée du démon aux 'maladies de l'âme'. Ensuite on reprend l'article de Freud « Une névrose démoniaque au XVIIe siècle ¼ rédigé en 1923, lorsque Freud, étant donné son intérêt pour la sorcellerie, les possessions et les phénomènes apparentés, se consacre à l'étude du cas du peintre Christoph Haizmann qui, souffrant de convulsions et d'hallucinations effrayantes, fait un pacte avec le diable. Dans cet article, Freud établit les rapports entre la figure du démon et la figure paternelle en soulignant un enjeu fondamental pour l'étude de l'hystérie qui servira aux élaborations postérieures de Lacan sur ce thème.

Inicialmente, el trabajo tiene como objetivo delinear algunas referencias históricas sobre el tema de la histeria, especialmente en su perspectiva demonológica y las "teorías" que articulan la idea del demonio a las "enfermedades del alma". A continuación, se rescata el artículo freudiano "Una neurosis demoníaca del siglo XVII", de 1923, cuando Freud, a partir de su interés por la hechicería, posesiones y fenómenos similares, se dedica a estudiar el caso del pintor Christoph Haizmann que, atormentado por convulsiones y alucinaciones atemorizadoras, hace un pacto con el diablo. En el referido trabajo, Freud establece las relaciones entre la figura del demonio y la figura paterna destacando una cuestión fundamental para el estudio de la histeria, cuestión que servirá para las posteriores elaboraciones de Lacan sobre el tema.

Der vorliegende Artikel beschreibt zunächst einige historische Aspekte zum Thema der Hysterie, insbesondere die dämonologische Dimension und die "Theorien", welche die Idee des Teufels mit den "Seelenkrankheiten" verknüpfen. Freuds Artikel „Eine Teufelsneurose im siebzehnten Jahrhundert" (1923), verfasst in einer Zeit als Freud sich für Hexerei, Besessenheit und verwandte Phänomene interessierte, untersucht den Fall des Malers Christoph Haizmann. Da dieser an Krämpfen und furchterregenden Halluzinationen litt, schloss er einen Pakt mit dem Teufel. In seinem Artikel erörtert Freud die Beziehungen zwischen der Figur des Teufels und der väterlichen Figur, wobei er eine grundlegende Frage für das Studium der Hysterie hervorhebt, die den späteren Ausführungen von Lacan zu diesem Thema dienen wird.

Palatal obturator designed by 3-dimensional prototyping for a patient with a large ameloblastoma: a case report.

The aim of the present report was to detail the advantages of using 3-dimensional (3D) prototyping in the planning, modeling, and manufacturing of an immediate palatal obturator for a 62-year-old man who underwent a left total maxillectomy to remove a solid, multicystic ameloblastoma. The prosthesis provided favorable restoration of stomatognathic functions, including speech, swallowing, and mastication. The use of an immediate obturator prosthesis made with 3D technology is an important aid in the treatment of patients diagnosed with tumors in the head and neck region.

Clinique psychiatrique et ethique du sujet / Clínica psiquiátrica e ética do sujeito / Psychiatric clinic and ethics of the subject / Clínica psiquiátrica y ética del sujeto

Ce travail a pour objectif celui de relativiser les critiques psychanalytiques adressées au champ psychiatrique fondées sur la conception de l'existence unitaire, absolue et sans clivage, de quelque chose qui fonctionnerait comme étant «La Psychiatrie¼. En montrant les tensions existant au sein même de la psychopathologie psychiatrique par l'émergence du sujet et de sa singularité, nous cherchons à indiquer des pistes pour la construction d'une psychiatrie fondée sur une éthique du sujet et de son désir.

O objetivo deste trabalho é relativizar as críticas psicanalíticas dirigidas ao campo psiquiátrico fundadas na concepção da existência unitária, absoluta e sem clivagens de algo que funcionaria como "A Psiquiatria". Ao mostrar as tensões existentes na psicopatologia psiquiátrica pela emergência do sujeito e de sua singularidade, buscamos indicar maneiras de construir uma psiquiatria baseada na ética do sujeito e de seu desejo.

This work aims to relativize the psychoanalytic criticisms addressed to the psychiatric field based on the conception of the unitary, absolute and undivided existence of something that would function as "the Psychiatry ". By showing the tensions existing within psychiatric psychopathology by the emergence of the subject and his/her singularity, we seek to indicate ways of constructing a Psychiatry based on an ethics of the subject and of his/her desire.

El objetivo de este trabajo es relativizar las críticas psicoanalíticas, dirigidas al campo psiquiátrico, fundadas en la concepción de una unidad absoluta y sin la disociación de algo que funcionaría como "La Psiquiatría". Al presentar las tensiones existentes en la psicopatología psiquiátrica, debido a la emergencia del sujeto y a su singularidad, buscamos indicar maneras de construir una psiquiatría basada en la ética del sujeto y de su deseo.

Ziel dieser Arbeit ist es, die gegen die Psychiatrie gerichteten psychoanalytischen Kritiken zu relativieren, welche auf dem Konzept einer angeblich einheitlichen, absoluten und spaltungsfreien „Psychiatrie" basieren. Indem wir die Spannungen aufzeigen, die in der psychiatrischen Psychopathologie durch die Manifestation des Subjekts und seiner Singularität bestehen, versuchen wir Wege aufzuzeigen, eine Psychiatrie auf der Grundlage der Ethik und des Wunsches des Subjekts aufzubauen.

Impact of Histological and Endoscopic Remissions on Clinical Recurrence and Recurrence-free Time in Ulcerative Colitis.

BACKGROUND: Clinical and endoscopic remissions constitute the therapeutic goals in ulcerative colitis (UC). Histological healing is currently not a target in UC. This study aims to determine the impact of the definition of endoscopic remission (Mayo endoscopic subscore [MSe] 0-1) and histological activity in the recurrence of UC and recurrence-free survival time. METHODS: Patients with UC in clinical remission (partial Mayo score ≤ 1) and endoscopic remission (MSe ≤ 1) who underwent colonoscopy with biopsies between March 2010 and December 2013 were included. The validated Nancy score was used to evaluate histological activity, which considers inactivity if 0 to 1 and activity if 2 to 4. The recurrence-free time was evaluated and recurrence was defined as partial Mayo score ≥ 2, therapy to induce remission, hospitalization, or colectomy. Predictive factors associated with recurrence and time to recurrence were determined. RESULTS: Sixty patients were included; 58.3% (n = 35) were women, with a mean age of 52.7 years. MSe = 1 was observed in 46.7% (n = 28) and histological activity in 38.3% (n = 23). Clinical recurrence occurred in 31.7% (n = 19) of patients, with a cumulative risk of 17.1%/24.5%/26.7%/40.1% at 12/24/36/48 months, respectively. MSe = 1 (P = 0.02) and histological activity (P = 0.007) were significantly associated with recurrence. Of these, only histological activity (P = 0.03) was an independent predictive factor of recurrence. Patients with MSe = 1 (P = 0.02) and with histological activity (P = 0.01) had a significantly shorter recurrence-free time in univariate analysis. In multivariate analysis, only histological activity (P = 0.02) was an independent predictive factor of lower recurrence-free time. CONCLUSION: The presence of histological activity represents an independent predictive factor of recurrence and time to recurrence, which was not verified with MSe 0 to 1.

Habitar, construir, existir: algunas consideraciones sobre el cuerpo en las psicosis / Habitar, construir, existir: algumas considerações sobre o corpo nas psicoses / To inhabit, to build, to exist: considerations concerning the body in psychoses / Habiter, bâtir, exister: quelques considérations sur le corps dans les psychoses / Wohnen, bauen, existieren: einige Überlegungen zum Körper in Psychosen / 住留，构建，存在：对肉体与精神世界的关系的思考

Desde Freud, Lacan y de un importante texto de Heidegger, que se ocupa del tema del habitar, se destaca la cuestión de la inscripción del cuerpo — la primera morada — desde el encuentro con el Otro. La ausencia del significante de la falta impide el psicótico de, en ciertas situaciones, apropiarse del sentido desencadenando la psicosis. La invención del cuerpo propio es una vía de rescate de la ruptura de la realidad y de la estabilización en las psicosis.

A partir de Freud, de Lacan e de um importante ensaio de Heidegger, que trata do tema do habitar, destaca-se a questão da inscrição do corpo — primeira morada — a partir do encontro com o Outro. A ausência do significante da falta impede o psicótico de, em certas situações, se apropriar do sentido fato que produz o desencadeamento da psicose. A invenção do corpo próprio resgata o sujeito da errância produzida pelo rompimento da realidade e produz a estabilização na psicose.

Based on Freud, Lacan and on an important essay by Heidegger dealing with the topic of inhabiting, the question concerning the inscription of the body — the first home — is highlighted following an encounter with the Other. The absence of the meaning of lack prevents the psychotic person, in certain situations, from appropriating for himself the sense fact that leads to the onset of psychosis. The invention of the personal body saves the subject from the wanderings produced by the disruption of reality, and leads to stabilization of the psychosis.

Depuis Freud, Lacan et un important essai de Heidegger traitant du thème de l’habiter, on distingue la question de l'inscription du corps — la première demeure — à partir de la rencontre avec l'Autre. L'absence du signifiant du manque empêche le psychotique, dans certains cas, de s'approprier le sens, fait qui produit le déclenchement de la psychose. L'invention du corps lui-même délivre le sujet de l'errance produite par la rupture de la réalité et produit la stabilisation dans la psychose.

Freud, Lacan und ein wichtiger Aufsatz Heideggers, der sich mit dem Thema Wohnen beschäftigt, bilden die Grundlage unserer Analyse über die Inskription des Körpers — der erste Wohnort — ab der Begegnung mit dem Anderen. Die Abwesenheit des Signifikanten des Mangels hindert den Psychotischen daran, in bestimmten Situationen, sich den Sinn anzueignen, ein Umstand der den Ausbruch der Psychose erzeugt. Die Erfindung des eigenen Körpers rettet das Subjekt vom Umherirren, welches durch den Bruch mit der Realität erzeugt wurde und erzeugt eine Stabilisierung in der Psychose.

佛罗依德，拉孔，甚至海德格尔的一篇重要的文章，都探讨了关于精神在肉体的住留问题，特别是关于肉体和精神的相遇，肉体“注册”成为精神的第一栖息地。专家指出，精神和肉体的缺乏有意义的协调，在某些情况下，会阻碍精神驾驭感知，从而引发精神病。我们认为对肉体的干预是解决精神和肉体关系不协调的一种办法，一种稳定精神病症的办法。.

O infantil na constituição subjetiva: restos, escrita e narrativa / The infantile in the constitution of the psyche: remains, inscription and narrative / L’infantile dans la constitution subjective : restes, écriture et narration / El infantil en el proceso de la constitución subjetiva: restos, escritura y narrativa / Das Infantile in der subjektiven Konstituition: Spuren, Schreiben und Erzählung / 童年在主观的构成：遗体、书写和叙述

O artigo descreve as trilhas do processo de constituição do psiquismo, como processo de inscrição de traços e da construção de um registro. Para tanto são introduzidos alguns aspectos fundamentais da teoria de Lacan: a falta do objeto, o traço, a letra, o significante, a repetição e o gozo. O objetivo principal é demonstrar que no campo da letra, no litoral entre o significante e o gozo, é possível delimitar com maior precisão o real estatuto da noção de infantil para a teoria e para a clínica psicanalítica, distinguindo-o, simultaneamente, da noção de infância.

This article describes the ways of the constitution process of the psyche as an inscription process of traits and the creation of a record. Some fundamental aspects of Lacan’s theory were used to that end, such as the lack of object, the trait, the letter, the significant, the repetition, and the jouissance. Our main goal was to demonstrate that in the field of the letter, i.e., the zone between the significant and the jouissance, one may delimit the real status of the term ‘infantile’ more precisely, in terms of both the theory and the psychoanalytic clinic, thereby distinguishing it from the term ‘childhood’.

Cet article décrit les étapes du processus de la constitution du psychisme comme processus d’inscription de traits et de construction d’un registre. Dans ce but, nous introduisons certains aspects fondamentaux de la théorie lacanienne : le manque de l’objet, le trait, la lettre, le signifiant, la répétition et la jouissance. L’objectif principal de cet article est de démontrer que dans le champ de la lettre, dans le littoral entre le signifiant et la jouissance, il est possible de définir très nettement la condition réelle du terme ‘infantile’, non seulement pour la théorie, mais aussi pour la clinique psychanalytique et de le distinguer du terme ‘enfance’.

El artículo describe la senda del proceso de constitución del psiquismo como un proceso de inscripción de trazos y de la construcción de un registro. Para ello, se introducen algunos aspectos fundamentales de la teoría de Lacan: la falta del objeto, el trazo, la letra, el significante, la repetición y el gozo. El objetivo principal es demostrar que, en el campo de la letra, en la margen entre el significante y el gozo, es posible delimitar con mayor precisión la verdadera constitución de la noción de infantil, para la teoría y para la clínica psicoanalítica, distinguiéndolo, simultáneamente, de la noción de infancia.

Dieser Artikel beschreibt die Wege des Aufbauprozesses der Psyche als Inskription von Zügen und Erstellung eines Verzeichnisses. Zu diesem Zweck werden einige der wichtigsten Aspekte der Theorie Lacans eingeführt: Objektmangel, der Zug, der Buchstabe, der Signifikant, die Wiederholung und das Genießen. Dieser Artikel will an erster Stelle aufzeigen, dass es im Bereich des Buchstabens – in der Grauzone zwischen dem Signifikant und dem Genießen – möglich ist, den realen Stellenwert des Begriffs 'Infantil' für die Theorie und die psychoanalytische Klinik zu definieren und ihn gleichzeitig vom Begriff 'Kindheit' zu unterscheiden.

本文介绍了心灵建设过程的途径，例如印象的痕迹和记录的建立。因此需要引入拉康的理论中的一些基本理念：对象的缺乏，痕迹，字，能指，重复和享受。其主要目的是论证在此属于能指和享受的交界处的“字”领域可以更准确的定下童年在理论和精神临床的实际地位，而从此区分童年的概念。.

Indigofera suffruticosa Mill (Fabaceae): hepatic responses in mice bearing sarcoma 180 / Indigofera suffruticosa Mill (Fabaceae): respuestas hepáticas en ratones portadores de sarcoma 180

Indigofera suffruticosa is a plant generally used to treat infectious and inflammatory processes. This work aims to evaluate the histopathological changes in the liver tissue of mice with Sarcoma 180 after subchronic treatment with aqueous extract obtained by infusion and maceration of Indigofera suffruticosa leaves. Male mice were divided into four groups of six animals: G1, G2 and G3 patients with Sarcoma 180 and Sarcoma 180 G4 without sarcoma. G1 and G2 were treated with infusion mashing respectively (50 mg/kg ip); G3 and G4 controls received saline (15 ml/kg ip). The histopathological and morphometric analysis of liver tissue after subchronic treatment with aqueous extracts by infusion and maceration of the groups G1, G2 and G4 were similar and showed no degraded areas or leukocyte infiltration compared to G3, which shows a marked destruction of liver architecture. The results showed that after subchronic treatment with the aqueous extract of leaves Indigofera Suffruticosa obtained by infusion and maceration, the hepatic architecture was preserved, suggesting its use as an alternative hepatoprotective agent.

Indigofera suffruticosa es una planta utilizada para tratar procesos infecciosos e inflamatorios. Este trabajo tiene como objetivo evaluar los cambios histopatológicos en el tejido del hígado de ratones con sarcoma 180 después del tratamiento subcrónica con el extracto acuoso obtenido por infusión y maceración de las hojas de Indigofera suffruticosa. Los ratones machos fueron divididos en cuatro grupos de seis animales: pacientes G1 , G2 y G3 con Sarcoma 180 y G4 sin Sarcoma. G1 y G2 fueron tratados con infusión de maceración respectivamente (50mg/kg.ip); Controles G3 y G4 recibieron solución salina (15 ml/kg.ip). El análisis histopatológico y morfométrico de tejido hepático después de un tratamiento subcrónico con extractos acuosos por infusión y la maceración de los grupos G1, G2 y G4 fueron similares y no mostraron áreas degradadas o la infiltración de leucocitos en comparación a G3, que muestra una marcada destrucción de la arquitectura del hígado. Los resultados mostraron que después de un tratamiento subcrónico con el extracto acuoso de hojas de Indigofera suffruticosa obtenidos por infusión y la maceración, se conservó la arquitectura hepática, lo que sugiere su uso como una alternativa de agente hepatoprotector.