[The dependence of estradiol and progesterone reception in the endometrium on its histological structure in women with the syndrome of luteal phase failure]. / Zavisimost' retseptsii éstradiola i progesterona v éndometrii ot ego gistostruktury u zhenshchin s sindromom nedostatochnosti liuteinovoi fazy tsikla.

A study of the level of the sex steroid receptors in the endometrium of women with the syndrome of insufficiency of the luteal phase of the cycle (ILP-syndrome) has shown that disorders of receptor processes affect, first of all, progesterone receptors. An increase in a degree of a delay of endometrial development was accompanied by a rise of the level of progesterone in the endometrium which depended on the estradiol-progesterone ratio in the circulation, detectable on the 20th day of the menstrual cycle. The ILP-syndrome is characterized by the sufficient induction of progesterone receptors at the end of the proliferative--the beginning of the luteal phase of the cycle and by their insufficient inhibition with a low level of progesterone in the middle of the luteal phase. Insufficient synthesis of receptors as a result of sharp hypoestrogenemia is less frequent. The primary affection of the receptor apparatus as a cause of the ILP-syndrome against a normal hormonal background in the examinees was undetectable.

[Endometrial estradiol and progesterone receptors in women with various clinical forms of luteal insufficiency]. / Retseptsiia éstradiola i progesterona v éndometrii u zhenschin s razlichnymi klinicheskimi formami liuteinovoi nedostatochnosti.

Changes in uterine estradiol and progesterone receptor content in patients with luteal insufficiency (the insufficient luteal phase/ILP/ syndrome developing in the presence of tubal and uterine inflammations, hyperandrogenism or insignificantly increased prolactin level were described. The level of steroid receptors is correlated to blood levels of the respective hormones throughout the cycle. It is suggested that changes in sex steroid receptors are secondary to disorders of progesterone and estradiol secretion in cases of the ILP syndrome developing in the presence of uterine and tubal inflammations, and in patients with increased blood prolactin. In hyperandrogenic patients with the ILP syndrome, nuclear progesterone receptors night possibly be inadequate.