Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 8 de 8
Filtrar
1.
Shanghai Kou Qiang Yi Xue ; 27(4): 415-418, 2018 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-30483712

RESUMO

PURPOSE: To investigate the expression and significance of YAP and TAZ proteins in oral squamous cell carcinoma. METHODS: From February 2014 to March 2017, 113 oral squamous cell carcinoma specimens were selected, and the adjacent tissues (away from carcinoma >2 cm) were selected as the control. Immunohistochemical staining was used to detect the expression of YAP and TAZ protein, and its relationship with clinicopathological features were evaluated with SPSS 19.0 software package. RESULTS: The positive rate of YAP and TAZ protein in cancer tissues was 65.49% and 61.95%, respectively, which was significantly higher than that in the adjacent tissues (P<0.05). The positive expression of YAP protein in patients with low differentiation, cervical lymph node metastasis, stage Ⅲ, tumor diameter>4 cm were 83.64%, 80.33%, 82.35% and 82.61%, significantly higher than that inpatients with high differentiation, without cervical lymph node metastasis, stage I-II, tumor diameter ≤4 cm (P<0.05). The positive expression rate of TAZ protein in patients with low differentiation, stage III, tumor diameter >4 cm was 80%, 85.29% and 82.61%, significantly higher than that in patients with high differentiation, stage I-II, tumor diameter ≤4 cm (P<0.05). The expression of YAP protein was positively correlated with the expression of TAZ protein (rs=0.571, P<0.05). CONCLUSIONS: YAP and TAZ proteins are strongly expressed in oral squamous cell carcinoma, closely related to the clinical and pathological features such as the degree of differentiation and the diameter of the tumor, suggesting that Hippo signaling pathway may be involved in the development of oral squamous cell carcinoma.


Assuntos
Carcinoma de Células Escamosas , Metástase Linfática , Neoplasias Bucais , Proteínas Adaptadoras de Transdução de Sinal , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Humanos , Neoplasias Bucais/metabolismo , Neoplasias Bucais/patologia , Fosfoproteínas
2.
Ann Plast Surg ; 75(6): 610-4, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25180948

RESUMO

The objective of this study was to evaluate a total parotidectomy performed through a face-lift incision integrated with a temporal fascia flap. We have accomplished a group of 40 cases of total parotidectomy from July 2008 to May 2013. Twenty-two cases accepted a modified performance which combined rhytidectomy incision with temporal fascia flap. The other 18 cases were fulfilled by Blair incision and no reconstruction of parotid bed as control. The patients were followed up every 6 months. In the interviews, the assessment of the operation from patients was recorded. The cosmetic gratification, presence or absence of gustatory flushing or sweating, and functional reversion of facial nerve and great auricular nerve were surveyed by 3 investigators. The criteria that integrated the subjective with objective items were stipulated for evaluation. Gustatory sweating had been identified in 0% and 44% of patients of the testing and control group, respectively. The average scale of the experimental and control group postoperatively was 7.89 and 5.93 individually. The difference of the average scale between testing and control group presented statistical significance. The author's technique is either aesthetically satisfying or efficacious to prevention of gustatory sweating in total parotidectomy.


Assuntos
Fasciotomia , Glândula Parótida/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Retalhos Cirúrgicos , Sudorese Gustativa/prevenção & controle , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Ritidoplastia , Sudorese Gustativa/etiologia , Resultado do Tratamento
3.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 43(1): 104-7, 117, 2012 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-22455143

RESUMO

OBJECTIVE: To develop an estimating formula for glomerular filtration Rate (GFR) based on serum cystatin C in patients with chronic kidney disease (CKD). METHODS: Clinical characteristics of 242 CKD patients were collected. The patients were randomly divided into modeling group and model validation group. The rGFR obtained from 99mTc-DTPA clearance rate was used as a reference value of GFR. s-cystatin C was detected by latex enhanced immunoturbidimetric method. Preliminary linear regression analysis followed by multiple linear regression were performed to investigate the association between s-cystatin C and rGFR. The validity of the estimation formula was tested in the model validation group in comparison with Hoek formula and Orebro formula. RESULTS: With standardised countdown conversion, s-cystatin showed linear correlation with rGFR, with a correlation coefficient of 0.773. The multiple correlation coefficient, determination coefficient, adjusted R square and std. error of the estimation model were 0.863, 0.745, 0.742, and 0.207, respectively. The residuals P-P probability plot analysis showed that the model residuals fitted into normal distribution with homogeneity of variance. Theeformula was: eGFR = 67/s-cystatin C +3. No significant difference was found between the distribution of eGFR and rGFR. Our formula had an accuracy of 30% and 50%, which were no less than those obtained from Hoek formula and Orebro formula. The new formula also had acceptable bias and high precision. The Bland-Altman analysis and ROC curve analysis showed good applicability of the new formula. CONCLUSION: The GFR prediction formula we established has a good prediction performance as comparised with other formulae, which could be used in measuring GFR in CKD patients.


Assuntos
Cistatina C/sangue , Taxa de Filtração Glomerular/fisiologia , Nefropatias/fisiopatologia , Insuficiência Renal Crônica/fisiopatologia , Adulto , Idoso , Doença Crônica , Feminino , Humanos , Nefropatias/metabolismo , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Insuficiência Renal Crônica/metabolismo , Reprodutibilidade dos Testes
4.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 41(4): 684-7, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20848796

RESUMO

OBJECTIVE: To determine the serum Urea levels in healthy adults living in urban Chengdu and to identify factors that influence the serum urea levels for the purpose of establishing reference interval. METHODS: Serum urea levels were determined in 17 787 healthy adults in urban Chengdu who underwent physical examinations. The characteristics of distribution of serum urea levels in the population and its relationships with liver function, renal function, serum glucose, and serum lipid were analyzed. RESULTS: Increased Crea, Uric, Glu, and HDL-C levels and decreased Glb level were associated with increased serum urea levels, which was independent of the impact of sex and age. The association between serum urea and Crea, Glu, and HDL-C existed in normal healthy adults. Men had higher urea levels than women. Regardless of gender, serum urea increased with age (with a cut off point at 30, 50, 60 and 70 years). CONCLUSION: Serum urea levels in healthy adults living in urban Chengdu vary in different gender and age groups. Serum urea levels are associated with serum Crea, Glu, the HDL-C levels. It is necessary to establish gender and age-specific reference intervals for serum urea.


Assuntos
Saúde da População Urbana , Ureia/sangue , Adulto , Idoso , China , Feminino , Humanos , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Valores de Referência
5.
Environ Toxicol ; 25(4): 409-17, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19526538

RESUMO

Carbon nanotubes (CNTs) have been synthesized and produced on large scale for their wide application. They have high absorption ability to organic contaminants (such as benzene) and can form CNTs-benzene combination with benzene. In this article, the acute pulmonary toxicity, induced by multiwall carbon nanotubes (MWCNTs), benzene, and their combination, was studied by administrating the three test materials into mice lungs via intratracheal instillation. The biochemical parameters in bronchoalveolar lavage fluid (BALF) and pathological lesions in lungs were used as endpoints to evaluate the pulmonary toxicity of the three test materials at 3-day and 7-day postexposure, respectively. After the mice were intratracheally instilled with MWCNTs, benzene and MWCNTs-benzene combination at doses of 6.67 mg/kg, 2.67 mg/kg, and 9.34 mg/kg (containing 6.67 mg/kg MWCNTs and 2.67 mg/kg benzene), the total protein, alkaline phosphatase (ALP), acid phosphatase (ACP), and lactate dehydrogenase (LDH) in BALF and pathological lesions in lungs were examined. At 3-day postexposure, MWCNTs induced obvious pulmonary toxicity and benzene only induced slight pulmonary toxicity, whereas their combination induced very severe pulmonary toxicity. At 7-day postexposure, MWCNTs and benzene did not induce pulmonary toxicity individually, whereas their combination still induced severe pulmonary toxicity. These data indicated that, at the instilled doses in this experiment, the MWCNTs can alone induce acute pulmonary toxicity in mice and the benzene does not induce pulmonary toxicity, but the pulmonary toxicity of MWCNTs is enhanced after they form MWCNTs-benzene combination with low dose of benzene. The enhanced pulmonary toxicity may be due to the change of MWCNTs aggregation ability after benzene is adsorbed on them.


Assuntos
Lesão Pulmonar Aguda/induzido quimicamente , Benzeno/toxicidade , Pulmão/fisiopatologia , Nanotubos de Carbono/toxicidade , Animais , Líquido da Lavagem Broncoalveolar/química , Pulmão/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos
6.
Genet. mol. biol ; 33(4): 605-609, 2010. ilus, mapas, tab
Artigo em Inglês | LILACS | ID: lil-571511

RESUMO

In the present study, we investigated the application of 13 short tandem repeat (STR) loci (D13S317, D7S820, TH01, D16S539, CSFIPO, VWA, D8S1179, TPOX, FGA, D3S1358, D21S11, D18S51 and D5S818) routinely used in forensic analysis, for delineating population relationships among seven human populations representing the two major geographic groups, namely the southern and northern Chinese. The resulting single topology revealed pronounced geographic and population partitioning, consistent with the differences in geographic location, languages and eating habits. These findings suggest that forensic STR loci might be particularly powerful tools in providing the necessary fine resolution for reconstructing recent human evolutionary history.


Assuntos
Humanos , Medicina Legal , Genética Populacional
8.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 41(7): 385-7, 2006 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-17067449

RESUMO

OBJECTIVE: To determine the causes and incidence of facial injuries by an epidemiologic retrospective study. METHODS: A total of 3 958 patients with facial injuries treated at Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University from 1955 to 2001 were investigated. Data regarding age, gender, cause of injury, pattern of fracture and associated systemic injuries were reviewed. RESULTS: The male to female ratio of the patients with facial injury was 4.27:1 and 33.4% of patients were aged between 21 and 30 years. The most common cause of injury was traffic accident (30.6%), followed by falls (21.4%) and collision (15.8%). A total of 794 patients (20.1%) showed only soft tissue injuries. 1 100 patients (27.8%) had multiple fractures in facial bones and 2,064 patients (52.1%) had single fracture. The mandibular fracture was most frequently seen, followed by the maxilla and the zygoma. The most common site of mandible fracture was the body (31.2%), followed by the symphysis (22.7%), the condylar (20.5%) and the angle (13.7%). Accompanied injuries to brain and skull happened in 916 patients (23.1%). CONCLUSIONS: Bone fractures were more common in hospitalized patients with facial injuries. The numbers and sites of fracture were related to the causes of injuries and anatomic structure of the bone. The brain and skull injuries, the most often and seriously accompanied injuries, would not be neglected.


Assuntos
Fraturas Mandibulares/epidemiologia , Traumatismos Maxilofaciais/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Lesões Encefálicas/etiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Fraturas Mandibulares/complicações , Fraturas Mandibulares/etiologia , Traumatismos Maxilofaciais/complicações , Traumatismos Maxilofaciais/etiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores Sexuais , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA