RESUMO
A new ursane-type triterpene, 3ß,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (1H-NMR, 13C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.
Assuntos
Antineoplásicos , Triterpenos , Anti-Inflamatórios/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Triterpenos/farmacologia , VietnãRESUMO
Five new compounds, named ancistronaphtosides A and B (1 and 2), anciscochine (3), anciscochine 6-O-ß-d-glucopyranoside (4), and 4'-methoxy-5-epi-ancistecrorine A1 (5), together with tortoside A (6) and 4-hydroxy-2-methoxyphenyl-6-O-syringoyl-ß-d-glucopyranoside (7) were isolated from the methanolic extract of Ancistrocladus cochinchinensis. Their chemical structures were established using HR-ESI-MS, NMR spectroscopic, and chiroptical methods. Compound 5 significantly exhibited anti-proliferation against HL-60, LU-1, and SK-MEL-2 cells with IC50 values of 5.0±1.2, 6.5±1.6, and 6.8±2.0µg/mL, respectively.