Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial.

This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels (p=0.045), a higher number of repetitions on the STS test (p=0.011), and increased walking distance on the 6MWT (p=0.010), compared to CG. Moreover, there was a reduction in the scores of the FIQ (p=0.001), the PSQI (p=0.001), the BDI (p=0.017), and pain assessed using VAS (p=0.008) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC; RBR-38nbbx) (https://ensaiosclinicos.gov.br/rg/RBR-38nbbx).

Immediate spirometric alterations after bronchoscopy in diffuse lung disease.

OBJECTIVE: To evaluate the spirometric alterations after bronchoscopy with bronchoalveolar lavage (BAL) and bronchoscopic lung biopsy in patients with diffuse lung disease (DLD). PATIENTS AND METHODS: Twenty-three patients with DLD and 6 individuals with solitary pulmonology nodule or dyspnea were subjected to BAL with the infusion of 4 aliquots of 50 mL of saline solution at room temperature; 3 to 5 bronchoscopic lung biopsy specimens were obtained from the locations based on chest x-ray and/or tomogram findings. Spirometry was perfomed before and 10, 30, and 60 minutes after the bronchoscopic procedure. RESULTS: A meaningful spirometric decrease within the group with DLD and in the control group was observed, being more intense 10 minutes after the completion of the examination, followed by a natural tendency of returning to initial baseline values after 60 minutes. The DLD group presented a more significant decrease (P<0.05) in: forced vital capacity 14.4%, forced expiratory volume in the first second 12.7%, peak expiratory flow rate 15.9%, forced expiratory flow at 50% volume 13.6%, and peripheral saturation of oxygen 3.6%. Despite the decrease in the spirometry, the group with DLD presented only minor complications, such as transitory hypoxemia and bleeding. CONCLUSIONS: Our results suggest that bronchoscopy associated with BAL and bronchoscopic lung biopsy is a safe procedure in patients with restrictive lung diseases, despite a decrease in their spirometric values.