Paradoxical action of PP2A inhibition and its potential for therapeutic sensitization.

The protein phosphatase 2A (PP2A), a serine/threonine phosphatase, is recognized as a tumor suppressor involved in diverse cellular processes and essential for maintaining cell viability in vivo. However, endogenous inhibitors of PP2A such as cancerous inhibitor of PP2A (CIP2A) and endogenous nuclear protein inhibitor 2 of PP2A (SET) counteract the anticancer function of PP2A, promoting tumorigenesis, development, and drug resistance in tumors. Surprisingly though, contrary to conventional understanding, inhibition of the tumor suppressor gene PP2A with exogenous small molecule compounds can enhance the efficacy of cancer treatment and achieve superior tumor inhibition. Moreover, exogenous PP2A inhibitors resensitize cancers to treatment and provide novel therapeutic strategies for drug-resistant tumors, which warrant further investigation.

Beyond the Spectrum: Unleashing the Potential of Infrared Radiation in Poultry Industry Advancements.

The poultry industry is dynamically advancing production by focusing on nutrition, management practices, and technology to enhance productivity by improving feed conversion ratios, disease control, lighting management, and exploring antibiotic alternatives. Infrared (IR) radiation is utilized to improve the well-being of humans, animals, and poultry through various operations. IR radiation occurs via electromagnetic waves with wavelengths ranging from 760 to 10,000 nm. The biological applications of IR radiation are gaining significant attention and its utilization is expanding rapidly across multiple sectors. Various IR applications, such as IR heating, IR spectroscopy, IR thermography, IR beak trimming, and IR in computer vision, have proven to be beneficial in enhancing the well-being of humans, animals, and birds within mechanical systems. IR radiation offers a wide array of health benefits, including improved skin health, therapeutic effects, anticancer properties, wound healing capabilities, enhanced digestive and endothelial function, and improved mitochondrial function and gene expression. In the realm of poultry production, IR radiation has demonstrated numerous positive impacts, including enhanced growth performance, gut health, blood profiles, immunological response, food safety measures, economic advantages, the mitigation of hazardous gases, and improved heating systems. Despite the exceptional benefits of IR radiation, its applications in poultry production are still limited. This comprehensive review provides compelling evidence supporting the advantages of IR radiation and advocates for its wider adoption in poultry production practices.

Insight into the effective electrocatalytic sulfide removal from aqueous solutions using surface oxidized stainless-steel anode and its desulfurization mechanism.

The electrochemical oxidation of hydrogen sulfide (H2S) has shown its potential for the real application of H2S emission control in wastewater treatment. In this study, a surface corrosion treatment of stainless steel (SS) was optimized by regulate Ni content in the oxide film on the SS AISI 304 surface for sulfide removal. The X-ray photoelectron spectroscopy and linear sweeping voltammetry results indicated a higher Ni content in the oxide film of surface-oxidized stainless steel (SOSS) attributed to a higher sulfide removal potential. Sulfide removal experiment results showed that SS-150 (with 150 s anodic pretreatment) anodes achieved the highest Ni content of 69% with the best sulfide removal efficiency, i.e., 97% within 48 h, which increased by 20% compared to the untreated SS. This study also demonstrated a strategy for in situ removal of deposited sulfur on the anodes by cathodic treatment at -0.38 V vs. RHE to alleviate the common issue of sulfur passivation. Density functional theory (DFT) calculation revealed that NiOOH was the major active species in SS-150 oxide film for a faster sulfide removal rate. The study developed a SS surface modification process for Ni content regulation that contributed to better sulfide removal efficiency.

Nickel-Catalyzed mesoporous biochar for enhanced adsorptive oxidation of aqueous Sulfide: An investigation of influencing factors and mechanisms.

Biochar (BC) is a low-cost and electroactive adsorbent for removing sulfide in aqueous media, which toxifies aquatic organisms and corrodes water treatment facilities. However, it lacks a pore structure for sulfide ion (S2-) mass transfer to active sites. Herein, it is shown that nickel-modified biochar (BC-Ni) adsorbed S2- 2.72-fold faster than BC alone and attained a 1244 ± 252 mg-sulfide/g maximum adsorption capacity due to markedly increased mesopores, while BC attained 583 ± 250 mg-sulfide/g. Factors influencing S2-sorption and theoretical sorption kinetics and isotherms models were evaluated. Structural and surface compositions of BC and BC-Ni were examined using state-of-the-art characterizations. The results suggest that S2- was adsorbed via pore diffusion, pore filling, and cation bridging and oxidized to elemental sulfur and sulfate with quinone and hydrogen peroxide generated from dehydrogenation of hydroquinone on the BC-Ni by metallic nickel in the carbon matrix. This study would spur biomass valorization and desulfurization.

Impacts of molybdate and ferric chloride on biohythane production through two-stage anaerobic digestion of sulfate-rich hydrolyzed tofu processing residue.

Biohythane production through one-stage anaerobic digestion of sulfate-rich hydrolyzed tofu processing residue has been hampered by high H2S production. Herein, two-stage anaerobic digestion was investigated with the addition of molybdate (MoO42-; 0.24-3.63 g/L) and ferric chloride (FeCl3; 0.025-5.4 g/L) to the dark fermentation stage (DF) to improve biohythane production. DF supplemented with 1.21 g/L MoO42- increased hydrogen yield by 14.6% over the control (68.39 ml/g-VSfed), while FeCl3 had no effect. Furthermore, the maximum methane yields of methanogenic fermentation were 524.8 and 521.6 ml/g-VSfed with 3.63 g/L MoO42- and 0.6 g/L FeCl3 compared to 466.07 ml/g-VSfed of the control. The maximum yields of biohythane and energy were 796.7 ml/g-VSfed and 21.8 MJ/kg-VSfed with 0.6 g/L FeCl3 when the sulfate removal efficiency was 66.7%, and H2S content was limited at 0.08%. Therefore, adding 0.6 g/L FeCl3 is the most beneficial in improving energy recovery and sulfate removal with low H2S content.

Combination of ultrasonic and acidic pretreatments for enhancing biohythane production from tofu processing residue via one-stage anaerobic digestion.

Tofu processing residues (TPR) have received more attention as a source of bioenergy. However, their low solubility has hindered biohythane generation. Consequently, the ultrasonic and H2SO4 pretreatments were combined and compared for the first time to improve the hydrolysis of organic matter and carbohydrate and increase free amino nitrogen generation from TPR. Besides, the impact of pretreatments on biohythane generation was investigated. Under the optimal conditions of 7.54% substrate level, 8% H2SO4 concentration, 80 °C and 50 min, the coincident ultrasonic-H2SO4 pretreatment enriched the contents of soluble chemical oxygen demand, reducing sugar, and free amino nitrogen to 49675 mg/L, 26 g/L, and 1721 mg/L, respectively, greater than individual pretreatments. Also, Biohythane yield increased by 4.24-13.61% over control (389.42 ± 23.7 ml/g-VSfed). Furthermore, hydrogen yield at 42.5 ± 2.08 and 28.1 ± 1.07 ml/g-VSfed and sulfate removal efficiency at 93 and 92% were significantly improved with ultrasonic-H2SO4 and H2SO4 pretreatments, respectively, indicating acidogenic and sulfidogenic activity enhancement.

Anaerobic co-digestion of fish processing waste with a liquid fraction of hydrothermal carbonization of bamboo residue.

The effect of different mixing ratios of fish processing waste (FPW) with a liquid fraction (LF) of hydrothermal carbonization (HTC) of bamboo residues on biogas and methane yield was investigated. The different mixing ratios (FPW + LF) and HTC temperature (200-280 °C) had significant effects on biogas and methane production. The anaerobic co-digestion of the various mixing ratio of FPW and LF of bamboo residues did not enhance the methane yield compared to the AD of FPW alone. However, a mixture of 75FPW + 25LF(2 2 0) presented a comparable methane production (133 mL/g VS) to that achieved with 100FPW (142 mL/g VS), which represents an increase of only 6.4%. The ratio of 75FPW + 25LF(2 2 0) increased the biogas yield by 81% compared to the control group of 100LF(2 2 0). The mixing ratio of 75 FPW + 25LF(2 2 0) did not require clean water input to dilute FPW for biogas production and can be a practical waste management method.