[Evaluation of clinical application of new remote radar monitoring equipment for obstructive sleep apnea].

Objective:The result consistency between the new remote radar monitoring equipment and PSG detection is compared. Methods:The monitoring results of 71 patients were randomly selected to observe and compare the difference of monitoring data of the same patient with two kinds of detection equipment. Results:Using AHI≥5 as the diagnostic criteria, compared with PSG monitoring results, the sensitivity, specificity and Youden index of the new remote radar monitoring equipment were 96.2%, 89.5% and 0.857（P<0.01） respectively. Compared with PSG monitoring results, when LSaO2≤90% in PSG monitoring, the sensitivity, specificity and Youden index of the new remote radar monitoring equipment were 94.3%, 88.9% and 0.832（P<0.01） respectively. Conclusion: There the new remote radar monitoring device can be used to monitor OSA.

Nrg1/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K/Akt pathway.

Sensorineural hearing loss (SNHL) is a common causes of disability. Neural stem cells (NSCs) from the cochlear nuclei have been considered to be a potential direction for the treatment of SNHL. Neuregulin 1 (NRG1)/ErbB2 signaling displays an essential role in nervous system development. In this study, we aimed to explore the roles of NRG1/ErbB2 in differentiation and apoptosis of cochlear nuclei NSCs. The data showed that the expression of NGR1 and ErbB2 in cochlear nuclei NSCs isolated from rats were increased with the age of rats. NRG1 treatment reduced the nestin-positive cells number, increased the MAP2-positive and GFAP-positive cells number, decreased the expression of cleaved-caspase-3, and increased the activation of PI3K/AKT. ErbB2 knockdown by lentiviral-mediated ErbB2 shRNA infection reversed the effect of NRG1 on cochlear nuclei NSCs. LY294002 administration further enhanced the effect of ErbB2 silencing on the expression of nestin, MAP2, GFAP and cleaved-caspase-3. Taken together, NRG1/ErbB2 regulates differentiation and apoptosis of cochlear nucleus NSCs through PI3K/Akt pathway.

[The MRI study of upper airway on obstructive sleep apnea hypopnea syndrome].

OBJECTIVE: To investigate the character of upper airway and to offer the reference for clinical treatment through observing the upper airway caliber and its corresponding pharyngeal wall of OSAHS patients by magnetic resonance imaging (MRI). METHOD: The upper airway of 33 obstructive sleep apnea hypopnea syndrome (OSAHS) patients diagnosed by PSG were analyzed and compared by MRI. The cross-sectional area of the upper airway and thickness of lateral parapharyngeal wall were calculated. The cross-sectional area of the upper airway and thickness of lateral and posterior pharyngeal wall were also measured in 20 nonsnoring age-matched normal subjects selected as the control group. RESULT: The cross-sectional areas of upper airway of OSAHS patients were smaller than that of the control. The Thickness of posterior pharyngeal wall and lateral pharyngeal wall of the retropalatal region, retroglossal region and epiglottal region were thicker in patients group than that of the control. The thickness and length of the palate in patients group were larger than that of the control. The cross-sectional areas of retropalatal region of OSAHS patients had negative correlation with apnea hypopnea index (AHI). There was also negative correlation between the retroglossal region cross-sectional area and the neck circumference. CONCLUSION: Measurement of upper airway with MRI could observe the change of pharynx cross-sectional area and had reference value in guiding the clinical diagnosis and treatment.

[Effect and evaluation of image guided navigation system in complex endoscopic endonasal surgery].

OBJECTIVE: To evaluate the effect of image guided navigation system (IGNS) in complex endoscopic endonasal surgery. METHOD: Three hundred and five patients were undergone endoscopic surgery using IGNS. The detailed information and data including the IGNS accuracy, the operation procedure time, the operator's satisfaction degree and self-confidence, and the perioperative complication were analysed and summarized to evaluate the effect of IGNS. RESULT: The operation procedures were successfully performed in all the 305 patients without perioperative complication. In 98.7% of the total operation IGNS provided an accurate anatomical localization less than 2 mm localization error (0.5-2.0 mm,mean 1.2 mm). The application of IGNS reinforced the operators self-confidence, increased the patients' safety with the almost same time as that of routine endoscopic surgery (ESS). CONCLUSION: IGNS could elevate the effectivity and security of ESS, indicating it's a valuable tool in deal with complex endoscopic endonasal surgery.

[Diagnosis and treatment of sphenochoanal polyp (3 cases report)].

OBJECTIVE: To investigate the role of transnasal endoscope in the diagnosis and treatment of sphenochoanal polyp. METHOD: Three cases of sphenochoanal polyp underwent transnasal endoscopic polypectomy and sinus surgery. RESULT: The patients were free of nasal obstruction and headache after operation. There were no recurrence and complications in the average 12 months of follow-up period. CONCLUSION: Endoscopic examination and CT scan are important in the diagnosis of sphenochoanal polyp. Endoscopic sinus surgery (ESS) is the treatment of choice in the management sphenochoanal polyp.