Distal transradial access decreases radial artery occlusion rate in percutaneous coronary interventions.

BACKGROUND: To investigate the incidence of complications such as radial artery occlusion (RAO) after distal or conventional transradial access in percutaneous coronary interventions, and to compare the advantages and disadvantages of those two approaches. METHODS: In this retrospective study, the data of 110 patients received either distal transradial access (dTRA) (n=56 cases) or conventional transradial access (cTRA) (n=54 cases) in percutaneous coronary interventions were analyzed to compare the incidence of RAO. RESULTS: The incidence of RAO in the dTRA group significantly decreased compared with that in the cTRA group (P<0.05). Univariate analysis indicated that smoking (r=0.064, P=0.011), dTRA (r=0.431, P<0.001), cTRA (r=0.088, P=0.015), radial artery spasm (r=-0.021, P=0.016), and postoperative arterial compression time (r=0.081, P<0.001) were exposure factors for the incidence of RAO. In multivariable analysis, independent risk factors for RAO were postoperative arterial compression time (P=0.038) and dTRA (P<0.001). CONCLUSIONS: dTRA shortened the postoperative arterial compression time and decreased the incidence of RAO compared with conventional transradial approach.

Characteristics, prognostic determinants of monocytes, macrophages and T cells in acute coronary syndrome: protocol for a multicenter, prospective cohort study.

BACKGROUND: Acute coronary syndrome(ACS) is the leading cause of mortality and disability worldwide. Immune response has been confirmed to play a vital role in the occurrence and development of ACS. The objective of this prospective, multicenter, observational study is to define immune response and their relationship to the occurrence and progressive of ACS. METHODS: This is a multicenter, prospective, observational longitudinal cohort study. The primary outcome is the incidence of major adverse cardiovascular events (MACE) including in-stent restenosis, severe ventricular arrhythmia, heart failure, recurrent angina pectoris, and sudden cardiac death, and stroke one year later after ACS. Demographic characteristics, clinical data, treatments, and outcomes are collected by local investigators. Furthermore, freshly processed samples will be stained and assessed by flow cytometry. The expression of S100A4, CD47, SIRPα and Tim-3 on monocytes, macrophages and T cells in ACS patients were collected. FOLLOW-UP: during hospitalization, 3, 6 and 12 months after discharge. DISCUSSION: It is expected that this study will reveal the possible targets to improve the prognosis or prevent from occurrence of MACE in ACS patients. Since it's a multicenter study, the enrollment rate of participants will be accelerated and it can ensure that the collected data are more symbolic and improve the richness and credibility of the test basis. ETHICS AND DISSEMINATION: This study has been registered in Chinese Clinical Trial Registry Center. Ethical approval was obtained from the Affiliated Hospital of Guizhou Medical University. The dissemination will occur through the publication of articles in international peer-reviewed journals. TRIAL REGISTRATION: Chinese Clinical Trial Registry: ChiCTR2200066382.

UTR-Dependent Control of Gene Expression in Plants.

Throughout their lives, plants sense many developmental and environmental stimuli, and activation of optimal responses against these stimuli requires extensive transcriptional reprogramming. To facilitate this activation, plant mRNA contains untranslated regions (UTRs) that significantly increase the coding capacity of the genome by producing multiple mRNA variants from the same gene. In this review we compare UTRs of arabidopsis (Arabidopsis thaliana) and rice (Oryza sativum) at the genome scale to highlight their complexity in crop plants. We discuss different modes of UTR-based regulation with emphasis on genes that regulate multiple plant processes, including flowering, stress responses, and nutrient homeostasis. We demonstrate functional specificity in genes with variable UTR length and propose future research directions.