RESUMO
Neurogenic autonomic dysfunction (NAD) is underdiagnosed, and it is likely in patients, who have orthostatic hypotension and symptoms from multiple organ systems as well as abnormal results from a neurological examination. A clinical and neurophysiological examination of the autonomic nervous system combined with a standardised paraclinical evaluation should be performed. NAD may be present in neurodegenerative disorders, vitamin deficiency, toxicity, infection, and in paraneoplastic, metabolic, hereditary and immune-mediated conditions.
Assuntos
Doenças do Sistema Nervoso Autônomo , Adulto , Algoritmos , Doenças do Sistema Nervoso Autônomo/complicações , Doenças do Sistema Nervoso Autônomo/diagnóstico , Doenças do Sistema Nervoso Autônomo/etiologia , Doenças do Sistema Nervoso Autônomo/terapia , Humanos , Hipotensão Ortostática/etiologia , Sistema Nervoso Parassimpático/anatomia & histologia , Sistema Nervoso Simpático/anatomia & histologiaRESUMO
Neurogenic autonomic dysfunction (NAD) and polyneuropathy occur in common conditions like diabetes and alcoholism. However, it can also be seen in rare diseases like in this case report of amyloid light-chain amyloidosis: primary amyloidosis. A 56-year-old man presented with polyneuropathy, a sympathetic dysfunction causing orthostatic intolerance, syncope, parasympathetic dysfunction and involvement of the enteric nervous system. The report illustrates, that routine screening can be insufficient in diagnosing amyloidosis. NAD and polyneuropathy without clear aetiology may require a multidisciplinary elucidation of more rare diseases.
Assuntos
Doenças do Sistema Nervoso Autônomo/diagnóstico , Amiloidose de Cadeia Leve de Imunoglobulina/diagnóstico , Doenças do Sistema Nervoso Autônomo/complicações , Humanos , Amiloidose de Cadeia Leve de Imunoglobulina/complicações , Amiloidose de Cadeia Leve de Imunoglobulina/patologia , Masculino , Pessoa de Meia-Idade , Inquéritos e QuestionáriosRESUMO
BACKGROUND: The aim of the present study was to evaluate the clinical importance of echocardiographic coronary flow velocity reserve (CFVR), resting and exercise left ventricular global longitudinal strain (LVGLS), and myocardial work efficiency (MWE) in patients with cardiac amyloidosis (CA). METHODS: The study population comprised 69 subjects: group A, 27 patients with CA confirmed by endomyocardial biopsy (CA positive); group B, 42 healthy control subjects. The amyloid phenotype in group A was as follows: patients with wild-type transthyretin-related amyloidosis (n = 10), carriers of the Danish familial transthyretin amyloidosis mutation with cardiac involvement (n = 5), and patients with amyloid light chain amyloidosis with cardiac involvement (n = 12). All subjects underwent comprehensive echocardiographic evaluation during rest and during symptom-limited, semisupine exercise testing. Furthermore, CFVR was assessed using Doppler echocardiography. RESULTS: Patients with CA had significantly lower CFVR (1.7 ± 0.6 vs 3.9 ± 0.8, P < .0001), MWE (1.9 ± 1.0 vs 3.0 ± 0.7, P < .0001), and LVGLS magnitude (11% [10%-14%] vs 20% [18%-21%], P < .0001) than control subjects. Patients with CA showed severely reduced deformation and efficiency reserve compared with control subjects (ΔLVGLS 0.9 ± 2.8% vs 5.6 ± 2.3%, P < .0001; ΔMWE 2.5 ± 2.8 vs 8.8 ± 2.6, P < .0001). In patients with CA, a strong relation was seen between physical capacity by the metabolic equivalent of tasks test and CFVR (r = 0.55, P < .01), peak exercise LVGLS (r = 0.64, P < .0001), and peak exercise MWE (r = 0.60, P < .01). CONCLUSIONS: Patients with CA had a profound lack of CFVR and longitudinal myocardial deformation reserve compared with healthy control subjects. Both parameters were significantly associated with exercise capacity and may prove useful for evaluating cardiac performance in patients with CA.
Assuntos
Amiloidose/fisiopatologia , Velocidade do Fluxo Sanguíneo/fisiologia , Cardiomiopatias/fisiopatologia , Circulação Coronária/fisiologia , Vasos Coronários/fisiopatologia , Ecocardiografia Doppler/métodos , Contração Miocárdica/fisiologia , Idoso , Amiloidose/diagnóstico , Biópsia , Cardiomiopatias/diagnóstico , Vasos Coronários/diagnóstico por imagem , Exercício Físico/fisiologia , Teste de Esforço , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Miocárdio/patologia , Estudos ProspectivosRESUMO
AIMS: This study aimed to characterize invasive haemodynamics during exercise in subjects with cardiac amyloidosis (CA). METHODS AND RESULTS: The study population numbered 44 subjects. Group A (CA-positive, n = 24) comprised wild-type transthyretin patients (n = 10), familial transthyretin amyloidosis mutation carriers (ATTRm) with cardiac involvement (n = 5), and light-chain amyloidosis patients with cardiac involvement (n = 9). Group B (CA-negative, n = 20) comprised four healthy ATTRm subjects without cardiac involvement documented by 11 C-PIB positron emission tomography and 16 healthy controls. All subjects underwent a symptom-limited, semi-supine exercise test with expired gas analysis and simultaneous right heart catheterization. CA patients had lower peak oxygen consumption [15 ± 6 mL/min/kg bodyweight (bwt) vs. 33 ± 7 mL/min/kg bwt; P < 0.0001] than controls. Myocardial reserve during exercise was significantly reduced in CA patients as reflected in a small increase in stroke volume index (SVI) and cardiac index (CI) compared with controls [ΔSVI: 4 mL/m2 (range: -1 to 8) vs. 14 mL/m2 (range: 5-25); P < 0.0001; ΔCI: 2 ± 2 L/min vs. 7 ± 2 L/min; P < 0.0001]. During exercise, CA patients had significantly higher left and right ventricular filling pressures than controls. Furthermore, CA patients had severely impaired pulmonary arterial compliance (PAC) compared with controls [2.9 mL/mmHg (range: 2.1-4.5) vs. 7.5 mL/mmHg (range: 5.7-10.4); P < 0.0001]. CONCLUSIONS: Cardiac amyloid deposits are associated with severely reduced inotropic myocardial reserve and increased left and right ventricular filling pressures during exercise. Furthermore, CA subjects have severely reduced PAC, which may contribute to right heart failure and reduced exercise capacity.
Assuntos
Amiloidose/fisiopatologia , Cardiomiopatias/fisiopatologia , Tolerância ao Exercício/fisiologia , Hemodinâmica/fisiologia , Contração Miocárdica/fisiologia , Função Ventricular Esquerda/fisiologia , Idoso , Amiloidose/diagnóstico , Cateterismo Cardíaco , Cardiomiopatias/diagnóstico , Progressão da Doença , Ecocardiografia Tridimensional , Teste de Esforço , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosAssuntos
Cardiomiopatias/genética , Pré-Albumina/genética , Idoso , Humanos , Mutação/genética , FenótipoRESUMO
Patients with cardiac amyloidosis are at increased AV-block and syncope risk. Therefore, a prophylactic pacemaker is often implanted. However, this case illustrates that other mechanisms should be ruled out prior to pacemaker implantation. The patient studied had mitral valve thickening without increased left ventricular outflow track (LVOT) velocity. However, bicycle exercise-stress test with simultaneous echocardiography revealed a stepwise decrease in blood pressure, a substantial increase in the LVOT velocity, and severe systolic anterior motion of the mitral valve. The patients' symptoms were likely explained by these findings. Therefore, a comprehensive clinical evaluation is warranted prior to pacemaker implantation in cardiac amyloidosis patients.
RESUMO
The present case illustrates the diagnostic challenges in symptomatic patients with heart failure of unknown etiology. The patients were previously diagnosed with κ-light chain amyloidosis without cardiac involvement. Echocardiography showed heart failure with mildly reduced ejection fraction but no signs of amyloidosis. Coronary angiogram showed normal arteries and 11C-PIB positron emission tomography was negative for amyloid deposits. Exercise testing revealed severe heart failure and reduced coronary flow velocity reserve. Endomyocardial biopsies showed amyloid in the intramural coronary arteries without interstitial amyloid deposits. Hence, the patient was diagnosed with microvascular dysfunction-induced heart failure due to vessel wall amyloidosis.
Assuntos
Amiloidose/diagnóstico , Cardiomiopatias/diagnóstico , Circulação Coronária/fisiologia , Vasos Coronários/patologia , Insuficiência Cardíaca/etiologia , Placa Amiloide/diagnóstico , Amiloidose/complicações , Amiloidose/fisiopatologia , Biópsia , Velocidade do Fluxo Sanguíneo , Cardiomiopatias/complicações , Cardiomiopatias/fisiopatologia , Angiografia Coronária , Vasos Coronários/fisiopatologia , Diagnóstico Diferencial , Ecocardiografia , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Placa Amiloide/complicações , Placa Amiloide/fisiopatologiaRESUMO
BACKGROUND: Familial transthyretin (TTR) amyloidosis is caused by different TTR mutations resulting in different clinical phenotypes of the disease. The Leu111Met mutation causes severe restrictive cardiomyopathy. Liver transplantation (LTx) is an established treatment option for patients with TTR amyloidosis; however, information on outcome after isolated LTx in patients with Leu111Met mutation amyloidosis is limited. METHODS: Between 2005 and 2012, six patients with TTR Leu111Met amyloidosis underwent isolated orthotopic LTx. None suffered from neuropathy. Prior to LTx, patients presented with echocardiographic manifestations of early cardiac amyloid involvement and in five endomyocardial biopsy was positive for TTR amyloid. RESULTS: Median age at LTx was 45.5 yr (range 39-54), and four were male (67%). All patients were alive at a median follow-up of 56.6 months (range 18-104). No surgical complications occurred. Two patients (33%) underwent cardiac transplantation during follow-up due to progressive cardiomyopathy. The remaining four patients experienced no echocardiographic or clinical deterioration of cardiac function following LTx. CONCLUSION: Isolated LTx appears to be a valuable treatment option for patients with familial TTR amyloidosis due to Leu111Met mutation. Appropriate timing of LTx is of utmost importance to avoid development of severe amyloid cardiomyopathy and the need for combined heart and liver transplantation.
Assuntos
Neuropatias Amiloides Familiares/cirurgia , Cardiomiopatias/prevenção & controle , Transplante de Fígado , Adulto , Ecocardiografia , Feminino , Seguimentos , Sobrevivência de Enxerto , Humanos , Masculino , Pessoa de Meia-Idade , Fenótipo , Prognóstico , Estudos Retrospectivos , Fatores de RiscoRESUMO
BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac condition associated with ventricular arrhythmias, heart failure, and sudden death. The disease is most often caused by mutations in the desmosomal gene for plakophilin-2 (PKP2), which is expressed in both myocardial and epidermal tissue. This study aimed to investigate protein expression in myocardial tissue of patients with AC carrying PKP2 mutations and elucidate whether keratinocytes of the same individuals exhibited a similar pattern of protein expression. METHODS AND RESULTS: Direct sequencing of 5 AC genes in 71 unrelated patients with AC identified 10 different PKP2 mutations in 12 index patients. One patient, heterozygous for a PKP2 nonsense mutation, developed severe heart failure and underwent cardiac transplantation. Western blotting and immunohistochemistry of the explanted heart showed a significant decrease in PKP2 protein expression without detectable amounts of truncated PKP2 protein. Cultured keratinocytes of the patient showed a similar reduction in PKP2 protein expression. Nine additional PKP2 mutations were investigated in both cultured keratinocytes and endomyocardial biopsies from affected individuals. It was evident that PKP2 mutations introducing a premature termination codon in the reading frame were associated with PKP2 transcript and protein levels reduced to ≈50%, whereas a missense variant did not seem to affect the amount of PKP2 protein. CONCLUSIONS: The results of this study showed that truncating PKP2 mutations in AC are associated with low expression of the mutant allele and that the myocardial protein expression of PKP2 is mirrored in keratinocytes. These findings indicate that PKP2 haploinsufficiency contributes to pathogenesis in AC.
Assuntos
Displasia Arritmogênica Ventricular Direita/genética , Epiderme/metabolismo , Haploinsuficiência , Miocárdio/metabolismo , Placofilinas/genética , Deleção de Sequência , Adolescente , Adulto , Displasia Arritmogênica Ventricular Direita/metabolismo , Feminino , Heterozigoto , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , Placofilinas/metabolismo , Adulto JovemRESUMO
OBJECTIVES: Thoracoscopic sympathectomy at levels T2 or T2-T3 is a treatment for focal hyperhidrosis and facial blushing. These levels of the sympathetic trunk innervate the heart, and consequently, the procedure is reported to change the heart rate variability due to changes in efferent cardiac autonomic activity. Our objective was to investigate the effects of thoracoscopic sympathectomy on global autonomic control, including baroreceptor sensitivity. METHODS: Eight patients (6 F, median age 28 years [range 20-58 years]) were exposed to the tilt-table test and cardiopulmonary exercise test before, and 3 months after, thoracoscopic sympathectomy. Eight healthy age-, gender- and BMI-matched controls were used as controls and underwent the same tests once. During tilt-table testing electrocardiogram, blood pressure, impedance cardiography and respiration were measured continuously, and efferent cardiac autonomic balance was estimated. RESULTS: The heart rate measured during orthostatic stress test was lowered after thoracoscopic sympathectomy (between-group; P = 0.01) due to a change in autonomic tone, with increased vagal (high-frequency power n.u.; P = 0.001), and reduced sympathetic efferent cardiac activity (low-frequency power n.u.; P < 0.001). Baroreceptor sensitivity measured during rest was increased (26 ± 13 vs 44 ± 19 ms/mmHg; P = 0.01), and diastolic blood pressure reduced after surgery (P = 0.01). The increases in systolic blood pressure and the sympathetic marker CCV-LF in response to orthostatic stress were higher before sympathectomy, with almost no increases post-surgically (condition × group interaction; P = 0.01 and P = 0.001, respectively). We found no change in post-procedure exercise capacity, although patients had a lower peak VO2 and maximal cardiac index than controls. CONCLUSIONS: Thoracoscopic sympathectomy changes the autonomic tone towards increased vagal activity; this is potentially cardioprotective. To our knowledge, this is the first study to show increased baroreceptor sensitivity after thoracoscopic sympathectomy.
Assuntos
Pressão Sanguínea/fisiologia , Frequência Cardíaca/fisiologia , Simpatectomia/métodos , Toracoscopia/métodos , Adulto , Análise de Variância , Afogueamento/fisiologia , Estudos de Casos e Controles , Teste de Esforço , Feminino , Humanos , Hiperidrose/cirurgia , Masculino , Pessoa de Meia-Idade , Pressorreceptores , Teste da Mesa Inclinada , Nervo Vago/cirurgiaRESUMO
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary cardiac condition associated with ventricular arrhythmias, heart failure, and sudden death. The most frequent ARVC genes encode desmosomal proteins of which mutations in desmoglein-2 (DSG2), account for 10%-20% of cases. This study aimed to investigate how DSG2 mutations contribute to the pathogenesis of ARVC. Initial mutation analysis of DSG2 in 71 probands identified the first family reported with recessively inherited ARVC due to a missense mutation. In addition, three recognized DSG2 mutations were identified in 12 families. These results and further mutation analyses of four additional desmosomal genes indicated that ARVC caused by DSG2 mutations is often transmitted by recessive or digenic inheritance. Because desmosomal proteins are also expressed in skin tissue, keratinocytes served as a cell model to investigate DSG2 protein expression by Western blotting, 2D-PAGE, and liquid chromatography-mass spectrometry. The results showed that heterozygous mutation carriers expressed both mutated and wild-type DSG2 proteins. These findings were consistent with the results obtained by immunohistochemistry of endomyocardial biopsies and epidermal tissue of mutation carriers, which indicated a normal cellular distribution of DSG2. The results suggested a dominant-negative effect of the mutated DSG2 proteins because they were incorporated into the desmosomes.
Assuntos
Displasia Arritmogênica Ventricular Direita/genética , Desmogleína 2/genética , Mutação de Sentido Incorreto , Western Blotting , Células Cultivadas , Cromatografia Líquida , Desmogleína 2/metabolismo , Feminino , Humanos , Masculino , Espectrometria de Massas , LinhagemRESUMO
BACKGROUND: Complex regional pain syndrome (CRPS) is a pain condition with regional sensory and autonomic abnormalities in the affected limb. The authors studied systemic autonomic and hemodynamic function in CRPS patients during rest, and during orthostatic and mental arithmetic stress. METHODS: Twenty patients with CRPS and 20 age-, sex-, and body mass index-matched control subjects participated. Mean values of heart rate variability, baroreceptor sensitivity, blood pressure, stroke volume, cardiac output, and total peripheral resistance were estimated during supine rest and 60° tilt-table testing. On a separate day, heart rate variability was also measured during mental arithmetic stress testing induced by a paced auditory serial addition task. RESULTS: Heart rate was increased and heart rate variability reduced in patients with CRPS patients compared with control subjects during rest and mental and orthostatic stress, whereas baroreceptor sensitivity was unaffected. When tilted from supine to upright position, patients with CRPS were not able to preserve cardiac output in comparison with control subjects, and they exhibited an exaggerated increase in the total peripheral resistance. The hemodynamic changes correlated to pain duration but not to pain intensity. CONCLUSION: The increased heart rate and decreased heart rate variability in CRPS suggest a general autonomic imbalance, which is an independent predictor for increased mortality and sudden death. The inability of the patients to protect their cardiac output during orthostatic stress was aggravated with the chronicity of the disease.
Assuntos
Síndromes da Dor Regional Complexa/fisiopatologia , Frequência Cardíaca/fisiologia , Intolerância Ortostática/fisiopatologia , Descanso/fisiologia , Estresse Psicológico/fisiopatologia , Adulto , Sistema Nervoso Autônomo/fisiopatologia , Índice de Massa Corporal , Eletrocardiografia , Feminino , Hemodinâmica/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Pressorreceptores/fisiologia , Fumar/fisiopatologia , Decúbito Dorsal/fisiologia , Teste da Mesa Inclinada , Adulto JovemRESUMO
BACKGROUND: Newly qualified doctors are expected to be able to conduct a cardiac auscultation unassisted, but studies show conflicting results regarding cardiac auscultation skills. METHODS: A two-part test instrument was designed containing innovative recordings of heart sounds from patients with common cardiac murmurs as well as healthy controls. A total number of 109 participants were tested, representing four levels of clinical experience. The content validity of the test instrument was studied by a postal questionnaire to 114 clinical teachers at the University Hospital of Aarhus, Denmark. RESULTS: A significant correlation was found between level of experience and the ability to diagnose the conditions from which the murmurs originated (r = 0.45, P < 0.0001). No correlation was found between level of experience and the ability to identify persons with cardiac murmurs from healthy controls. All groups showed a tendency to interpret healthy heart sounds as cardiac murmurs. CONCLUSIONS: Diagnostic ability was found to correlate positively with clinical experience, whereas the ability to distinguish cardiac murmurs from normal heart sounds seems independent of clinical experience.
Assuntos
Competência Clínica/normas , Auscultação Cardíaca/normas , Programas de Rastreamento/instrumentação , Dinamarca , Sopros Cardíacos/diagnóstico , Sopros Cardíacos/etiologia , Humanos , Estudantes de Medicina , Inquéritos e Questionários , Gravação em FitaRESUMO
INTRODUCTION: We have experienced a growing demand from patients for minimally invasive cardiac surgery. MATERIAL AND METHODS: From March 2006 through November 2007 we performed endoscopic mitral valve surgery in 30 patients (20 mitral valve repairs, eight mitral valve replacements and two extirpations of mitral valve fibroelstoma). Seven patients had concomitant surgery, including cryomaze to eliminate atrial fibrillation and/or closure of an atrial septal defect (ASD). Median preoperative functional class was New York Heart Association (NYHA) II and all patients had severe mitral valve regurgitation. The mean age was 58.0 +/-3 years and 27% of the patients were females. RESULTS: The procedure was performed successfully in all patients with no conversion to sternotomy, while postoperative morbidity was very limited and no mortality was seen. Early echocardiographic follow-up showed fully competent mitral valve repairs. CONCLUSION: Endoscopic mitral valve surgery is an attractive alternative to conventional sternotomy with an attractive cosmetic result. This can be obtained without compromising quality or safety. This paper confirms that endoscopic mitral valve surgery is feasible and it provides the least invasive operative approach. The technique is currently our primary surgical approach for mitral valve disease.
Assuntos
Implante de Prótese de Valva Cardíaca/métodos , Valva Mitral/cirurgia , Ecocardiografia Transesofagiana , Endoscopia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/cirurgia , Complicações Pós-Operatórias/diagnóstico , Resultado do TratamentoRESUMO
BACKGROUND: The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. STUDY DESIGN: The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. IMPLICATION: If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.
Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana/cirurgia , Insuficiência da Valva Mitral/cirurgia , Isquemia Miocárdica/cirurgia , Implante de Prótese Vascular , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/mortalidade , Insuficiência Cardíaca/etiologia , Insuficiência Cardíaca/mortalidade , Hospitalização , Humanos , Insuficiência da Valva Mitral/etiologia , Insuficiência da Valva Mitral/mortalidade , Isquemia Miocárdica/etiologia , Isquemia Miocárdica/mortalidade , América do Norte , Projetos de Pesquisa , Países Escandinavos e Nórdicos , Índice de Gravidade de Doença , Fatores de Tempo , Resultado do TratamentoRESUMO
OBJECTIVE: The aim of this study was to determine the prevalence of moderate ischemic mitral regurgitation (IMR) in the contemporary CABG population. We also aimed to correlate the effective regurgitant orifice area (ERO) of any regurgitant mitral valve in patients with coronary artery disease with the semiquantitative integrated scale of IMR. DESIGN: From March 15 through June 15, 2006, 510 consecutive CABG patients in three tertiary centres were included in the study. All patients showing any sign of mitral regurgitation (MR) at the referring hospital underwent a preoperative transthoracic echocardiographic estimation of the degree of MR using the integrated scale (1-4) and ERO. RESULTS: IMR was found in 141 patients (28%). The prevalence of moderate 2+ or worse IMR was 4% (95% CI; 2.5-6.1%) and the ERO corresponding to 2+ IMR or more ranged from 5 to 30 mm(2). Fourteen patients had an ERO between 15-30 mm(2). CONCLUSIONS: According to our study, patients with moderate IMR, defined as an ERO between 15-30 mm(2), account for only 2.7% (95% CI; 1.5-4.7%) of a non-emergency CABG population.
Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana/cirurgia , Insuficiência da Valva Mitral/etiologia , Isquemia Miocárdica/etiologia , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/epidemiologia , Dinamarca/epidemiologia , Humanos , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/epidemiologia , Insuficiência da Valva Mitral/cirurgia , Isquemia Miocárdica/epidemiologia , Isquemia Miocárdica/cirurgia , Prevalência , Índice de Gravidade de Doença , Suécia/epidemiologia , UltrassonografiaRESUMO
The aim of this study was to evaluate whether the incidence of ventricular arrhythmias and heart rate variability were influenced by statin treatment and lipid levels in patients treated with an implantable cardioverter defibrillator (ICD). Heart rate variability measurements were performed in 86 patients with coronary heart disease and an ICD implant. The number of events with ventricular fibrillation and ventricular tachycardia were recorded during a 12-month period. This study lends little support for an antiarrhythmic effect of statins or any relation between plasma lipids and lipoproteins and malignant ventricular arrhythmias in patients with an ICD.
Assuntos
Doença das Coronárias/terapia , Desfibriladores Implantáveis , Frequência Cardíaca/efeitos dos fármacos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Lipídeos/sangue , Taquicardia Ventricular/terapia , Antagonistas Adrenérgicos beta/uso terapêutico , Idoso , Antiarrítmicos/uso terapêutico , Biomarcadores/sangue , Colesterol/sangue , Terapia Combinada , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estatística como Assunto , Taquicardia Ventricular/tratamento farmacológico , Taquicardia Ventricular/epidemiologia , Resultado do Tratamento , Triglicerídeos/sangue , Fibrilação Ventricular/terapiaRESUMO
Repetitive myocardial ischemia during daily life has been suggested as the underlying mechanism of reversible myocardial dysfunction, which may progress into a hibernating state. Thirty-seven patients with ischemic cardiomyopathy (ejection fraction 35 +/- 7%) underwent positron emission tomography (N-13 ammonia and 18-F-fluoro-2-deoxy-glucose [FDG]) and exercise testing before coronary artery bypass grafting (CABG) and 48- hour ambulatory electrocardiographic monitoring to detect ischemia before CABG and 6 months postoperatively. Reversibility of regional myocardial dysfunction was detected by echocardiographic follow-up at 5 days, 2 months, and 6 months after the operation. Preoperatively, ischemic episodes during daily activities were more common (2 [25th to 75th percentiles 0 to 4] vs 0 episodes, p <0.01) and duration of ischemia longer (9 [25th to 75th percentiles 0 to 37] vs 0 [25th to 75th percentiles 0 to 1] minutes, p <0.02) in patients with reversible dysfunction (n = 15) than in patients with irreversible dysfunction (n = 22). The number of ischemic episodes per patient correlated with the numbers of reversibly dysfunctional segments (p = 0.003), viable segments as seen by positron emission tomography (p <0.05), and flow-metabolic mismatch segments (p <0.05). CABG eliminated ambulatory ischemic episodes in patients with reversible dysfunction (0 episodes, p <0.05 vs before CABG). Preoperatively, all patients with reversible dysfunction had a positive exercise test (14 of 15 patients), whereas daily life ischemia was present in 60% of patients. Reversibly dysfunctional segments in patients with ambulatory ischemia had faster recovery of function (15 of 28 patients vs 2 of 12 patients recovered at 5 days, p <0.05), higher FDG uptake (0.86 +/- 0.19% vs 0.71 +/- 0.24%, p <0.05) than in patients without ambulatory ischemia, whereas perfusion was similar (0.63 +/- 0.20 and 0.62 +/- 0.19 ml/g/min). Thus, exercise-induced myocardial ischemia is associated with reversibility of myocardial dysfunction, but not all patients with reversible ischemic cardiomyopathy have ischemic attacks during daily life.
Assuntos
Isquemia Miocárdica/fisiopatologia , Disfunção Ventricular Esquerda/fisiopatologia , Atividades Cotidianas , Angiografia Coronária , Ponte de Artéria Coronária , Ecocardiografia , Teste de Esforço , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Ambulatorial , Isquemia Miocárdica/diagnóstico por imagem , Isquemia Miocárdica/cirurgia , Tomografia Computadorizada de Emissão , Disfunção Ventricular Esquerda/diagnóstico por imagem , Disfunção Ventricular Esquerda/cirurgiaRESUMO
It is unknown whether surgical revascularization of viable and chronic reversibly dysfunctional myocardium in patients with heart failure is associated with a favorable effect on the autonomic control of heart rate. We studied 38 coronary artery bypass surgery (CABG) patients with an ejection fraction of 36 +/- 7%. Before CABG, the patients underwent 48-hour ambulatory electrocardiographic monitoring to measure heart rate variability (HRV), echocardiography to assess left ventricular function, and positron emission tomography and low-dose dobutamine echocardiography to assess viability. Six months after CABG, ambulatory electrocardiographic monitoring and echocardiography were repeated to assess HRV and recovery of left ventricular function. In spite of viable myocardium and recovery of left ventricular function following CABG, HRV indices were reduced 6 months postoperatively. A potential prognostic benefit gained by revascularizing patients with viability may occur in spite of deteriorated autonomic control of heart rate.