[Changes in the cathepsin activity of reticuloendothelial cells under the effect of biologically active substances]. / Izmenenie urovnia aktivnosti katepsina v kletkakh retikuloendotelial'noi sistemy pod vliianiem biologicheski aktivnykh veshchestv.

The level of cathepsin D, an enzyme of the lysosomal origin was used as a criterion of the increase in the digestive capacity of macrophages under the action of biologically active substances. It was shown that the use of prodigiosan changed the enzyme activity in the cells of the peritoneal exudate and spleen of the albino mice. Increased activity of cathepsin D was considered as a state of increased readiness for phagocytosis.

[Effect of several antibiotics and their combination with prodigiozan on Y. pestis EV, engulfed by macrophages]. / Vliianie mekotorykh antibiotikov i ikh sochetanii s prodigiozanom na Y. pestis EV, pogloshchennye makrofagami.

The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y. pestis EV) located inside the cells was studied. Peritoneal macrophages of albino mice with aceptic inflammation of the abdominal cavity caused by intraperitoneal administration of 2 ml of sterile meat-peptone broth were used in the experiments. The ratio of the macrophages and microbes was 1 : 50. A part of the mice were treated with prodigiozan 24 hours before taking the exudate. The preparations of the macrophages of albino mice with the microbes absorbed by them served as the control. The effect of the antibiotics and their combinations with prodigiozan was stimated by the coefficient of multiplication suppression against the control. The observations were made in dynamics. The studies showed that the macrophage activity of the mice treated with prodigiozan after exposure to the antibiotics was reliably higher than that in the control and digestion of the microbes located inside the cells started earlier, providing more complete phagocytosis.