[Studies of effects of aluminum oxide nanoparticles after intragastric administration].

Growing Wistar rats received intragastrically nanoparticles (NPs) of aluminum oxide (Al2O3) daily during 28 days at doses of 1 or 100 mg per kg body mass. There were studied body mass of animals, relative mass of internals, rate of protein macromolecules absorption in the gut, oxidative damage of DNA, pool of tissue thiols, activity of hepatic enzymes of xenobiotic detoxication system, biochemical and hematological blood indices, stability of lysosome membranes, condition of antioxidant defense system, apoptosis of hepatocytes. Conducted experiments didn't reveal any marked toxic action of Al2O3 NPs on rats after 28 days of administration both in high and low dose. Among effects probably related to NPs influence on animals there were lowering of relative liver and lung masses, decrease of hepatic thiol pool, activity of CYP1A1 isoform in liver and glutathione reductase in erythrocytes, increase of diene conjugates of fatty acids in blood plasma. Said shifts were small in magnitude, didn't come out of margins of physiological norm and didn't show any distinct relation to NPs dose. However considering great importance of this nanomaterial as probable environmental contaminant the studies of it's toxicity must be continued in conditions of low doses (less than 1 mg per kg body mass) for long period of time.

[Influence of hypocaloric diet with supplemented biologically active substances with antioxidant activity on clinicometabolic parameters in type 2 diabetes mellitus patients].

It was investigated the influence of a diet with supplemented biologically active substances (catechins, flavanols and other) with antioxidant activity on dinamics clinicometabolic parameters in type 2 diabetes mellitus patients. It was shown that inclusion of biologically active addition as the source of catechins, flavanols and other polyphenols in complex of treatment in type 2 diabetes mellitus contributes to increase hypotensive, hypoglycemic, hypolipidemic and antioxidant efficacy dietary therapy.

[Energy metabolic in patients with ischemic heart disease before and after heart surgery].

The study involved 85 patients with coronary heart disease (CHD). The parameters of metabolic status the actual food intake with the help of a new computer program, based on frequency method were investigated from patients with cardiovascular diseases. It was found a disbalanse of intake main food components and low physical activity in of patients.

[Vitamin and mineral supply of patients with cardiovascular diseases].

Analysis of dietary intake for the month before admission using the food frequency method in patients with cardiovascular diseases (CVD) showed high level consumption of vitamin C, excessive consumption of phosphorus and deficiency in consumption of vitamins A, B1, B2. 82% of patients had low calcium excretion per 1 kg of body mass, 16% of people had high level of bone resorption. In the group of patients with low calcium consumption, content of all the vitamins in daily ration was significantly lower, than that in the group with adequate calcium consumption. High spread of osteopenia among patients with CVD was expected because of deficiency in calcium consumption and their lowe supply with vitamin D, that appears risk factors of osteoporosis. But, actually, only 10% of patients had osteopenia and only 2 from 132 osteoporosis. Knowing that 95% of patients were overweighted, we suppose that low spread of osteopenia may be caused by estrogen-producing ability of fatty tissue.

[Influence of dietary therapy containing sunflower oil fortified with phospholipids on the lipid metabolism in patients with hypertension and obesity].

It was investigated the influence of dietary therapy containing sunflower oil with phospholipids (PL) on the lipid profile of plasma and composition of fatty acids of red blood cells in patients with hypertension and obesity. The results show that after the period of three weeks for each diet the unrefined sunflower oil supplemented with PL (30 gr oil containing 10, 8 gr PL) in diet had more influence on lowering of blood pressure (specially on diastolic BP). This diet reduced serum total cholesterol, low density lipoprotein (LDL), apolipoprotein A 1, apoB and fibrinogen more than the refined sunflower oil diet. This oil presents useful source of polyunsaturated fatty acids and essential PL for diets aimed at prevention of heart disease.

[The clinical and experimental research of metabolic effects of shark liver oil].

The investigation of influent of antiatherosclerotic diets with shark liver oil on clinical and metabolic parameters in patients with cardiovascular diseases. Results of the study show that enrichment of a diets with shark liver oil in patients with ischemic heart disease and hypertension improved clinic status, antropometric levels, lipid spectrum of blood and immunology status. The mechanism of shark liver oil was investigated in rats.

[The influence of a diet with including amaranth oil on antioxidant and immune status in patients with ischemic heart disease and hyperlipoproteidemia].

It was investigated the influence of a diet supplemented with amaranth oil on dynamic of antioxidant and immune status in 125 patients with ischemic heart disease and hyper-lipoproteidemia. The efficacy of diets with different contents of squalene (100, 200, 400, 600 mg per day) was compared. It was shown that antiatherosclerotic diet with inclusion 600 mg squalene has promoted the most positive changes of immune status. The consumption of 200-400 mg of squalene per day produced the more significant antioxidant effect.

[The use of nutritional antioxidants for the correction of metabolic disorders of cardiovascular patients]. / Ispol'zovanie pishchevykh antioksidantov v korrektsii metabolicheskikh narushenii u bol'nykh s serdechno-sosudistymi zabolevaniiami.

The effectiveness of complex dietary therapy, comprising the use of nutritional antioxidants, for patients with degree I-II essential hypertension and CHD has been evaluated. It is found that the including of soy isoflavones and selenium into the nutrition had a positive effect on the clinical presentation of disease, lipid metabolism, organism antioxidant status, indices of blood coagulation and anticoagulation systems.

[Research of antioxidant defence system under alimentary induced oxidative stress]. / Issledovanie sistemy antiokislitel'noi zashchity v usloviiakh alimentarno indutsirovannogo okislitel'nogo stressa.

Alimentary induced oxidative stress and its corrections in children and adults with homocysteine metabolism disorder are urgent problems for arteriosclerosis and cardiovascular disease prophylactics. For determination antioxidant status GSH-Px, SOD, GSH-reductase, catalase activities were detected. Effectiveness of Se-contained antioxidant complex "Selenec" was determined in experimental model with pubertal male Wistar rats. Including high value of methionine to semipurified diet with pyridoxine and folate deficiency induced oxidative stress. Lipid peroxidation substances were increased in blood, liver, intestine mucous tunic, aortal endothelium and myocardium. GSH-Px, SOD, GSH-reductase, catalase activities decreased significant compared to control. "Selenec" supplementation caused a decrease of thiobarbituric-reactive substances level, increasing SOD and catalase activity and decreasing GSH-Px and GSH-reductase activity in blood, liver, intestine mucous tunic, aorta and myocardium.

[Effect of a biologically active supplement (BAD) "SeleniumES" on the antioxidant system in patients with cardiovascular diseases]. / Issledovanie vliianiia BAD "SelenES" na sostoianie antioksidantnoi sistemy u bol'nykh s serdechnososudistymi zabolevaniiami.

The use of the dietary supplement SeleniumEC resulted in the normalization of markers of the lipid peroxidation and the antioxidant system during complex diet therapy of patients with ischemic heart diseases. These markers were more stable in patients received SeleniumEC further one month after the period in the clinic.

[Comparative study of effects of diet therapy including eiconol or linseed oil on several parameters of lipid metabolism in patients with type 2 diabetes mellitus]. / Sravnitel'naia otsenka vliianiia dietoterapii s vkliucheniem éikonola ili l'nianogo masla na nekotorye pokazateli lipidnogo obmena u bol'nykh sakharnym diabetom 2 tipa.

It was investigated the influence of a diet supplemented with polyunsaturated fatty acids (PUFA) omega-3 on dynamic of basal glycaemia, lipid profile and composition of fatty acids of erythrocytes in type 2 diabetic patients. Traditional 9 diet was supplemented with fish ("Eiconol", 8 grams per day) or vegetable (linseed oil, 17.5 grams per day) PUFA omega-3. The results investigations indicated that a omega-3 PUFA-enriched diet has a beneficial effects on lipid metabolism. But dietary administration of PUFA omega-3 may be used differently for correction of dislipoproteinemia in diabetic patients.

[Effects of biologically active supplements on the antioxidant and vitamin status of patients with hypertension and ischemic heart disease]. / Vliianie biologicheski aktivnykh dobavok na antioksidantnyi status i obespechennost' vitaminami u bol'nykh gipertonicheskoi i ishemicheskoi bolezn'iu serdtsa.

Biologically active additives in integrated therapy of patients with cardiovascular diseases against a background body overweight. The influence of antiaterosclerotic diet with including some biologically active additives, which contain vitamins C, E, B2, B6, beta-carotene, Zn, Mg, Na, K, Ca, I was studied in 91 patients with ischemic heart disease, hypertension disease. The usage of biologically active additives during 4 weeks has promoted positive changes of clinical symptoms of diseases against a background of lowering of serum cholesterol, triglycerides and increasing of vitamins A, E, C, B2, B6.

[Study of the state of lipid peroxidation system: antioxidant protection during the use of soy oil in patients with ischemic heart disease and hypertension]. / Izuchenie sostoianiia sistemy perekisnogo okisleniia lipidov--antiokislitel'noi zashchity pri ispol'zovanii soevogo masla u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu.

Usage of antisclerotic diet with PUFA n-3 from soy oil in patients with IHD and HBP resulted in positive dynamic of clinic manifestation, blood lipids and coagulogramms of the patients. The decrease of intensity of lipid peroxidation was also revealed. The results showed that soy oil may be recommended for preventive and treatment diets.

[Effects of a diet including linseed oil on clinical and metabolic parameters in patients with type 2 diabetes mellitus]. / Vliianie diety s vkliucheniem l'nianogo masla na kliniko-metabolicheskie pokazateli u bol'nykh sakharnym diabetom 2 tipa.

It was investigated the influence of a diet supplemented with PUFA omega-3 (linseed oil) on dynamic of basal and postprandial glycemia, blood pressure, lipid levels, parameters of lipid peroxidation in 60 patients with non-insulin-dependent diabetes mellitus. Linseed oil was used as a dietary supplement of PUFA omega-3. The results indicated that a diet supplemented with linseed oil (17.5 g/day) did not increase the effect of dietary therapy in correction of glycemia, hypertension and atherogenic lipid levels. It was not the activation of lipid peroxidation.

[Antioxidant index of erythrocytes in therapeutic nutrition monitoring]. / Antioksidantnyi indeks éritrotsitov v monitoringe lechebnogo pitaniia.

The antioxidant index (AOI) of erythrocytes in the form of the polynomial including, on the one hand, positive value of antioxidant enzymes activities (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and, on the other hand, fixed concentrations of lipid peroxidation products (malonic dialdehyde and diene conjugates). Informative significance of this index together with variance data are shown for different groups of patients. In monitoring of the condition of patients of the course diet therapy AOI may play an essential role.

[Vitamin and mineral status of the population living in the Sverdlovsk region]. / Obespechennost' vitaminami i nekotorymi mineral'nymi élementami naseleniia Sverdlovskoi oblasti.

It was found that low nutritional status for vitamin C, B2, beta-carotene, selenium and calcium are most prominent nutritional problem for population of Sverdlovskaja region of Russia. Level of calcium in serum was low in 50% of examined population. The results suggest the necessity of dietary intake and food contamination assessments for this population.

[Effects of mineral contents of a ration on indicators of radiation resistance of the body]. / Vliianie mineral'nogo sostava ratsiona pitaniia na pokazateli radiorezistentnosti organizma.

Relationship between the levels of calcium, potassium, and iron in rations and the indexes of antioxidant system of rats exposed to prolonged 137Cs loading was studied. Calcium deficiency was found to weaken the antioxidant system. Increased intake of potassium and iron provide high level of adaptation of the antioxidant system.

[The antioxidant defense system in hypertension patients on a diet enriched with omega 3 polyunsaturated fatty acids and alpha-tocopherol]. / Issledovanie sistemy antiokislitel'noi zashchity u bol'nykh gipertonicheskoi bolezn'iu pri obogashchenii diety polinenasyshchennymi zhirnymi kislotami omega3 i alpha-tokoferolom.

A state of the anti-oxidation system in blood and the rate of lipid peroxidation were studied in patients with hypertension. High sensitivity of the anti-oxidation system enzymes to alterations in the diet fat composition was detected in the patients, nutrition of whom was evaluated in detail. Excessive doses of alpha-tocopherol, added to the diet enriched with omega 3-polyunsaturated fatty acids normalized lipid peroxidation and stabilized the enzyme activity involved in the anti-oxidation system. The integral parameter, proposed for evaluation of the anti-oxidation protection state and designated as "anti-oxidation index" involved estimation of catalase, superoxide dismutase, glutathione reductase and peroxidase activities as well as of content of malonic dialdehyde and diene conjugates in erythrocytes.