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Am J Dermatopathol ; 44(2): 126-128, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34132665

RESUMO

ABSTRACT: Adjuvant radiation may be used to reduce the recurrence of high-risk cutaneous squamous cell carcinoma after resection. Adjuvant radiation can produce histologic changes in the skeletal muscle that mimic keratinocyte atypia, presenting a diagnostic challenge during subsequent resections. We present a case of cutaneous squamous cell carcinoma and histologic changes observed in a fresh frozen section that were consistent with degenerative changes of irradiated skeletal muscle that had a muscle-specific actin+, Melan-A-, and cytokeratin- immunophenotype on paraffin-embedded permanent sections. We also reviewed the literature of other similar reported findings on irradiated skeletal muscle.


Assuntos
Carcinoma de Células Escamosas/radioterapia , Músculo Esquelético/patologia , Radioterapia Adjuvante/efeitos adversos , Neoplasias Cutâneas/radioterapia , Idoso , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Humanos , Masculino , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia
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