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BACKGROUND: Spinal Malignant peripheral nerve sheath tumours (MPNSTs) are very rare aggressive tumours with poor prognosis. Little is known about these tumours in sub-saharan Africa. OBJECTIVES: This study aims to evaluate the clinical profile and outcome of management of these tumours in a resource limited country. METHODS: We retrospectively analysed data from the records of patients who had surgery for spinal MPNSTs at our center between January 2004 and December 2018. RESULTS: There were four patients in this study (M:F= 1:1). The ages ranged from 27-53 years with a mean of 43.25 ± 11.84 years. The tumour was located in the thoracic region in 2 of the patients (50%), the lumbar region in one (25%) and thoracolumbar in the 4th patient. Three patients (75%) presented with back pain while limb weakness, sensory deficit and sphincteric dysfunction were present in all patients at presentation. The duration of symptoms were 2 months in 2 patients (50%) and 3 months in the other 2. None of the patients had neurofibromatosis. Gross total tumour excision was achieved in 2 patients (50%) and subtotal resection in the other 2. The tumours were high grade in three patients (75%) and low grade in one. Two patients had adjuvant radiotherapy. Two of the patients were dead within 6 months of the diagnosis, another one within 18 months while one patient is still alive 3 years after. CONCLUSIONS: MPNSTs are very rare in our practice. Most of the tumours were high grade tumours and ran an aggressive course.
Assuntos
Neoplasias de Bainha Neural , Neurofibrossarcoma , Adulto , Humanos , Pessoa de Meia-Idade , Neoplasias de Bainha Neural/diagnóstico , Neoplasias de Bainha Neural/epidemiologia , Neoplasias de Bainha Neural/cirurgia , Neurofibrossarcoma/diagnóstico , Nigéria/epidemiologia , Estudos RetrospectivosRESUMO
BACKGROUND: Syringomyelia is an often progressive disorder of the spinal cord. There is a dearth of reports in the African population. AIMS AND OBJECTIVES: This study describes the profile and the outcome of treatment in our population of patients. DESIGN OF THE STUDY: A retrospective review of patients surgically treated for syringomyelia over a ten year period. SETTING: Department of Neurological Surgery, University College Hospital, Ibadan, Nigeria. MATERIALS AND METHODS: Eight patients were surgically treated for Syringomyelia over the period 2004-2014. We extracted data on their gender, age, aetiology, syrinx location, diagnosis, operative procedure and outcome. Simple statistical analysis was done. RESULTS: There were five males and three females. The mean age was 31.6(SD15.3) years (median: 32.5 years). The causes of the syrinx were: Chiari malformation (3), intramedullary spinal tumour (2), foramen magnum tumour (1), post-traumatic (1), and iatrogenic chemical arachnoiditis (1). The syrinx location was: cervical region (4), cervicothoracic region (2) and multi-level (2). The operative procedures were posterior fossa decompression (2), sub-occipital craniectomy with laminectomy and tumour excision (2), laminectomy and syringomyelotomy (2), laminectomy and tumour excision (1), and ventriculoperitoneal shunting (1). The duration of follow up was 2 weeks to 35 months. Outcome was satisfactory in six patients. A child who had initial ventriculoperitoneal shunting died at home before definitive surgery, and an adult male died of respiratory insufficiency post operatively. CONCLUSION: Syringomyelia is rare in our population. It affects young patients, typically in the cervico-thoracic region. The aetiologies are similar to those from previous reports. The outcome of surgical treatment in our small group of patients is satisfactory.
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OBJECTIVE: There is a dearth of information on operated cases of spinal tumors in patients in sub-Saharan Africa. The objective of this study was to evaluate the histologic pattern, anatomic distribution, and extent and outcome of surgery of Nigerian patients with spinal tumors. METHODS: This retrospective study comprised a cohort of Nigerians who underwent surgery for spinal tumors. Data obtained included patient demographics, duration of symptoms, anatomic location, imaging findings, Frankel grading before and after surgery, and type and outcome of surgery. Univariate analysis was performed, and results were compared with results from other parts of the world. RESULTS: There were 59 patients (male-to-female ratio 1:1.1) with a bimodal age distribution. The highest (20.34%) incidence was seen in the 20-29 age group. More than half (58.06%) of the patients presented with a duration of symptoms of at least 6 months (duration of symptoms was >12 months in 35.48%). Motor deficit was present in 97.73% of patients at presentation. Functional grading was Frankel A in 38.10% of patients, Frankel C in 26.19%, Frankel B in 16.67%, Frankel D in 16.67%, and Frankel E in 2.38%. The tumors were mostly in the thoracic region (65.45%), and 58% were extradural in location. Gross total tumor excision was performed in 50.88% of the cases, and subtotal resection was performed in 24.56%. Spinal stabilization was performed in 17.86% with spinous process wiring and vertical strut being the most common method of stabilization (80%) among this group. Metastasis was the most common histologic tumor type (23.21%). Meningioma accounted for 12.50% of tumors, and ependymoma, astrocytoma, and hemangioma each accounted for 7.14%. The most common source of metastasis was the prostate (38.46%). Postoperatively, 45% of patients improved neurologically, 52.5% remained the same, and 2.5% deteriorated. There was no perioperative mortality. CONCLUSIONS: Metastasis was the most common histologic type of spinal tumor in this study, and the most common location was extradural. The outcome was satisfactory in most cases with neurologic function remaining the same or improving after surgery in most patients.
Assuntos
Procedimentos Neurocirúrgicos/métodos , Neoplasias da Coluna Vertebral/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Doenças do Sistema Nervoso/epidemiologia , Doenças do Sistema Nervoso/etiologia , Nigéria , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Neoplasias da Coluna Vertebral/patologia , Neoplasias da Coluna Vertebral/secundário , Coluna Vertebral/cirurgia , Resultado do Tratamento , Adulto JovemRESUMO
AIMS AND OBJECTIVES: . This is a review of the initial experience with surgical management of upper cervical spine injuries. MATERIALS AND METHODS: The clinical case notes of patients surgically managed for UCSI were analysed for aetiology, presentation, duration of symptoms before presentation and surgery, pre- and post-operative Frankel grading, nature of injury and type of surgery. RESULTS: Eleven male and one female patients (mean age; 41.8 years; range 22-58 years) with UCSI were managed surgically. All the patients were involved in road traffic crashes. The case distribution were odontoid peg fracture [type II] alone (2 cases), hangman fracture alone (5 cases), both C1/2 subluxation and odontoid peg fracture (4 cases) and complex C2 injury (1 case). The surgical management includes C1 posterior ring excision and occipitocervical fusion [C0 - C4] (one patient), modified Gallie fusion alone (six patients), combined modified Gallie fusion and Rogers interspinous wiring (three patients). One patient each had C1/C2 interspinous wiring and combined modified Gallie fusion and occipito-cervical fusion [C0 - C4]. Post-operatively, two patients improved from Frankel C to D, 2 patients from C to E and one patient from D to E. The other patients with Frankel D and E injuries pre-operatively remained in status quo post-operatively. Eleven of the patients were discharged home on progressive ambulation with one having neck stiffness and one patient died 7 weeks post- surgery. CONCLUSION: Odontoid peg and hangman fractures were the most common indications for upper cervical spine surgery for trauma in our unit, and the post- operative outcome appears satisfactory.
Assuntos
Vértebras Cervicais/lesões , Vértebras Cervicais/cirurgia , Acidentes de Trânsito , Adulto , Vértebras Cervicais/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Processo Odontoide/lesões , Radiografia , Estudos Retrospectivos , Traumatismos da Coluna Vertebral/diagnóstico por imagem , Traumatismos da Coluna Vertebral/cirurgia , Adulto JovemRESUMO
INTRODUCTION: Although modern neuroimaging has facilitated early care of brain tumors in children worldwide, there are, however, few published reports on clinical profile, treatment, and outcome of brain tumors in children from our subregion. PURPOSE: We aimed to retrospectively study the clinical profile and outcome of pediatric brain tumors in a tertiary referral center from a developing country. METHODS: Forty pediatric patients with histologically verified brain tumors managed by the authors over a 13-year period (May 1994-April 2006) were studied. Patients' data from clinical, radiological, and pathology records were analyzed using the statistical package for social sciences version 16. RESULTS: The mean age was 9.75 years (range 1-15 years). Twenty-two males, 18 females. Common presenting symptoms were headaches (23 patients, 57.5%) and seizures (15 patients, 37.5%). Hyperreflexia (72.5%) and focal motor deficits (62.5%) were the most common neurologic signs. The mean interval from onset of symptoms to neurosurgical diagnosis was 13.4 months (95% CI). All patients had tumor resection, while 11 (27.5%) patients received adjuvant radiotherapy. Hydrocephalus occurred in 19 (47.5%) patients and was associated with early presentation (X2 = 10.65, p < 0.01). Low-grade astrocytoma (25%) and medulloblastoma (25%) were the most common tumors. Survival at 1 and 5 years were 56 and 47%, respectively. CONCLUSION: Focal motor signs and elevated intracranial pressure are the salient presenting features of brain tumors in children seen in Nigeria. Those of them with hydrocephalus are likely to present early. The outcome for pediatric brain tumors remains poor.
Assuntos
Astrocitoma/terapia , Neoplasias Encefálicas/terapia , Meduloblastoma/terapia , Procedimentos Neurocirúrgicos , Radioterapia Adjuvante , Adolescente , Astrocitoma/complicações , Astrocitoma/diagnóstico , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/diagnóstico , Neoplasias Cerebelares/complicações , Neoplasias Cerebelares/diagnóstico , Neoplasias Cerebelares/terapia , Criança , Pré-Escolar , Países em Desenvolvimento , Feminino , Cefaleia/etiologia , Humanos , Hidrocefalia/etiologia , Lactente , Masculino , Meduloblastoma/complicações , Meduloblastoma/diagnóstico , Nigéria , Prognóstico , Reflexo Anormal , Estudos Retrospectivos , Convulsões/etiologia , Taxa de Sobrevida , Centros de Atenção TerciáriaRESUMO
Proper policy implementation is the building block of every group, organization and society. Like every edifice, it requires proper, clear and distinct purpose, plan, materials and masons, to borrow a leaf from Aristotle's four causes. There are always challenges associated with this very important endeavour, but there are peculiarities to it in the context of Nigeria as a developing nation and with respect to cancer prevention and management as a complex and sophisticated activity. This work seeks to clarify and comment on the concepts of policy, administration, cancer treatment and prevention, and then highlight challenges to successful implementation of cancer treatment and prevention policy in Nigeria and propose some solutions.
Assuntos
Implementação de Plano de Saúde/organização & administração , Política de Saúde , Neoplasias/prevenção & controle , Administração em Saúde Pública , Tomada de Decisões Gerenciais , Humanos , Neoplasias/terapia , Nigéria , Política Organizacional , Formulação de Políticas , Administração em Saúde Pública/métodosRESUMO
The histology of the middle cerebral artery (MCA) in Nigerian Africans has not been previously studied. One hundred MCAs obtained at autopsy from fifty adult Nigerians were studied. The vessels were processed and stained with Ehrlich's haematoxylin and eosin, elastic Van Gieson and Masson's trichrome stains. Early branches were given off before the perforators in two middle cerebral arteries, and there was one accessory MCA, making an incidence of anomalies of 3 percent. No aneurysm was observed in any of the cases. The internal elastic laminas were well developed but the external elastic laminas of the vessels were poorly developed. Close to the bifurcations the tunica media tapered gradually and at the bifurcations, the tunica media was completely deficient being replaced by the tunica adventitia (Forbus raphé). The tunica adventitia was thicker at the bifurcations (0.21mm) compared to other sites of the vessel. The average thickness of the MCA tunica media at its origin was 0.12mm while that of the tunica adventitia was O.lOmm. These results are similar to what has been described in the literature for Caucasians. It buttresses the assertion that anatomical anomalies of the MCA are rare. The seemingly low frequency of MCA aneurysms in Nigerian Africans is not due to its anomalies or histology.
La histología de la arteria cerebral media (ACM) de los africanos de Nigeria no ha sido previamente estudiada. Fueron examinadas 100 ACM, obtenidas en autopsias de 50 individuos nigerianos adultos. Las arterias fueron procesadas y teñidas con hematoxilina y eosina de Ehrlich, Van Gieson para fibras elásticas y tricrómico de Masson. Ramas proximales se originan antes de la división en dos arterias cerebrales medias, y había una ACM accesoria, constituyendo una incidencia de anomalías del 3 por ciento. No se observó aneurisma en ninguno de los casos. La lámina elástica interna estaba bien desarrollada, pero la lámina elástica externa de los vasos estaba pobremente desarrollada. Cerca de la bifurcación la túnica media es gradualmente cónica, la túnica media es totalmente deficiente siendo sustituida por la túnica adventicia (Forbus raphé). La túnica adventicia es más gruesa en las bifurcaciones (0.21mm) en comparación con otros lugares del buque. El grosor medio de la túnica media de ACM en su origen fue 0.12mm mientras que el de la túnica adventicia de O.lOmm. Estos resultados son similares a los que han sido descritos en la literatura para Caucásicos. Es importante la afirmación que las anomalías anatómicas de la ACM son raras. La aparentemente baja frecuencia de los aneurismas de ACM en nigerianos africanos no es debido a sus anomalías o a la histología.
Assuntos
Humanos , Masculino , Adulto , Feminino , Pessoa de Meia-Idade , Aneurisma Intracraniano/patologia , Artéria Cerebral Média/anormalidades , Artéria Cerebral Média/patologia , População Negra , Nigéria , Medição de RiscoRESUMO
Parkinsonism is a neurodegenerative clinical disorder characterized by varying combinations and degrees of rest tremor, rigidity, slowing of voluntary movements and postural instability. Amongst the aetiologic factors, massive post-craniotormy haematoma has not been previously considered. This report is to arouse the suspicion that vascular displacement in the midbrain resulting from a massive unilateral intracranial haematoma could lead to the unusual complication of Parkinsonism. This is the report of a 55-year old retired male banker, without any previously identifiable risk factor except for his age, who developed Parkinsonism following a huge acute extradural haematoma that complicated a craniotomy for the excision of a haemorrhagic convexity meningioma. The patient was placed on medical treatment resulting in a slow but progressive neurological improvement. Reports of Parkinsonism following post-tumour excision are probably, very rare. We, hereby, report a case of Parkinsonism complicating a gross total excision of a convexity meningioma.
Assuntos
Neoplasias Encefálicas/cirurgia , Craniotomia/efeitos adversos , Meningioma/cirurgia , Doença de Parkinson Secundária/etiologia , Antiparkinsonianos/uso terapêutico , Neoplasias Encefálicas/diagnóstico , Hematoma/diagnóstico , Hematoma/etiologia , Hematoma/cirurgia , Humanos , Hemorragias Intracranianas/diagnóstico , Hemorragias Intracranianas/etiologia , Hemorragias Intracranianas/cirurgia , Levodopa/uso terapêutico , Masculino , Meningioma/diagnóstico , Pessoa de Meia-Idade , Doença de Parkinson Secundária/tratamento farmacológico , Hemorragia Pós-Operatória/diagnóstico , Hemorragia Pós-Operatória/etiologia , Hemorragia Pós-Operatória/cirurgia , Tomografia Computadorizada por Raios XRESUMO
The anti-inflammatory effect of dexamethasone on the irradiated kidneys of adult Wistar rats (Rattus norvegicus) was studied. Eighteen adult Wistar rats were, after acclimatization, randomly divided into 3 groups of 6 animals per group. The control group had normal saline, receiving neither drugs nor radiation. The second group received normal saline and radiation. The third group received pretreatment with dexamethasone at 1mg/kg body weight/day for 2 days followed by radiation. Radiation was delivered to the animals as a single fraction of 2.5 Gy of gamma rays from Cobalt-60 source, using an AECL Theatron 780-C Teletherapy machine. After exposure to the different interventions, the animals were sacrificed on the 14th post-irradiation day and the kidneys dissected out from each animal. The renal tissues were subjected to histological processing, and then studied using an eyepiece objective ruler calibrated with a 2mm stage micrometer for histomorphometric studies. The result of the study showed that all irradiated animals suffered weight loss by the 14th day post-irradiation (p<0.05) irrespective of the additional treatment with dexamethasone and this was statistically significant. Histomorphometry showed that the maximum width of the glomerular capsule was significantly greater in the radiation groups than in the control at p<0.05. The maximal glomerular diameter was significantly greater in irradiated animals compared with the control animals at p<0.05. The outcome of this study showed that the intraperitoneal administration of dexamethasone at 1mg/kg body weight/day for 2 days prior to treatment with irradiation did not prevent weight loss nor ameliorate the swelling of the nephrons resulting from the effect of radiation injury to the Wistar rat.
Fue estudiado el efecto anti-inflamatorio de la dexametasona en riñones irradiados de 18 ratas Wistar adultas (Rattus norvegicus). Luego de la aclimatización, aleatoriamente se dividieron en 3 grupos de 6 animales por grupo. El grupo control recibió una solución salina normal, sin recibir drogas ni radiación. El segundo grupo recibió solución salina normal y radiación. El tercer grupo recibió tratamiento previo con dexametasona con 1 mg / kg de peso corporal / día, durante 2 días, seguido de radiación. Los animales fueron expuestos a radiación con una fracción independiente de 2.5 Gy de rayos gamma por una fuente de Cobalto-60, usando una máquina de teleterapia AECL Theatron 780-C. Después de la exposición a las diferentes intervenciones, los animales fueron sacrificados el día 14 post-irradiación y los riñones de cada uno de los animales fueron disecados. Los tejidos renales fueron sometidos a procesamiento histológico, y luego se estudiaron utilizando un objetivo ocular milimetrado calibrado a 2mm para el estudio histomorfométrico. Se demostró que todos los animales irradiados sufrieron pérdida de peso 14 días después de ésta (p <0.05), independientemente de los tratamientos adicionales con dexametasona , siendo estadísticamente significativo. La histomorfometría mostró que el ancho máximo de la cápsula glomerular fue significativamente mayor en los grupos irradiados que en el control en p <0.05. El diámetro máximo del glomérulo fue significativamente mayor en los animales irradiados en comparación con los animales control p <0.05. Los resultados de este estudio mostraron que la administración intraperitoneal, de 1 mg / kg de peso corporal / día durante 2 días, de dexametasona antes de comenzar el tratamiento con irradiación, no impide la pérdida de peso ni permite aliviar el edema de los nefrones, injuria producto de la radiación a las Ratas Wistar.
Assuntos
Animais , Ratos , Anti-Inflamatórios/uso terapêutico , Dexametasona/uso terapêutico , Nefrite/tratamento farmacológico , Lesões Experimentais por Radiação/tratamento farmacológico , Nefrite/etiologia , Ratos Wistar , Rim , Rim/efeitos da radiação , Rim/patologiaRESUMO
RESUMEN: Se estudió el efecto neuroprotector de la dexametasona, sobre el cerebelo post-natal en desarrollo irradiado de ratas Wistar. 75 neonatos de 1 día de edad fueron separados en 3 grupos; el grupo control no recibió ni drogas ni irradiación, un grupo irradiado y el otro irradiado con aplicación de dexametasona. Esta droga fue administrada una hora antes de la exposición de 5Gray (5Gy) de rayos gamma. El tejido cerebelar de cada grupo con 5, 9, 14, 21 y 25 días fueron procesados para estudios histológicos e histomorfométricos. El resultado del estudio demostró que la sola irradiación redujo significativamente el grosor de la capa granular externa, en los grupos con 5 y 14 día,s con un p0,05; la capa molecular en los ejemplares de 5, 9, 14 y 21 días con un p0,05 y la capa granular en las ratas de 5,9,14 y 25 días, con un p0,05. Cuando se combinó la dexametasona con irradiación, se observó un grosor significativamente diferente en la capa granular externa, en especímenes con 5, 9 y 14 días; en la capa molecular en los animales de 5, 14 y 21 días y en la capa granular en los que tenían 5 y 14 días, al compararlos con el grupo irradiado, con un p>0,05. El diámetro de las células de Purkinje (capa de Purkinje) aunque fue significativamente reducido en el grupo irradiado de 14 y 21 días, no fue significativamente diferente cuandos se administró dexametasona a los animales irradiados de 5, 9, 14, 21 y 25 días con un p0,05. Histológicamente, las células de la capa molecular, en el grupo irradiado de 9 y 14 días, fueron marcadamente gliosadas comparadas con las medianamente marcadas en los grupos control e irradiados-dexametasona. Hubo distorsión de la monocapa de Purkinje, con algunas células encontradas en la capa molecular o en la capa de Purkinje, en el grupo irradiado de 5, 9, 14 y 25 días. De los resultados de este estudio, se puede afirmar que la administración de 0,005 ml de dexametasona intraperitonealmente, una hora antes de una exposición a una irradiación, parece proteger el desarrollo del cerebelo de la rata, de lesiones producidas por irradiación.
Assuntos
Animais , Recém-Nascido , Ratos , Cerebelo/crescimento & desenvolvimento , Cerebelo , Cerebelo/efeitos da radiação , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Irradiação Craniana , Irradiação Craniana/veterinária , Córtex Cerebral , Córtex Cerebral/efeitos da radiação , Ratos Wistar/crescimento & desenvolvimentoRESUMO
INTRODUCTION: The central nervous system (CNS) is an important site of HIV infection. As many as one quarter of AIDS patients present with neurological symptoms and up to 75% of the patients may have CNS abnormalities at autopsy. Under these circumstances therefore, differential diagnoses in HIV-positive patients with neurological symptoms constitute a management challenge. OBJECTIVE: To describe the pattern of cranial computed tomographic (CT) findings in neurosurgical patients with HIV infection. STUDY DESIGN: Retrospective analysis. PATIENTS AND METHOD: A total of 1907 patients were admitted from October 1996 to October 2001. Sixteen patients were positive for HIV using the Western blot. We reviewed their biodata, clinical features and cranial CT findings. RESULTS: There were 10 male and 6 female patients. Twelve patients had cranial CT. Four patients had lesions that could be attributed to direct infection by HIV virus. Two patients had lesions that suggested immunosuppression from HIV infection. Diffuse breakdown in blood brain barrier (BBB) with contrast enhancement as well as mass effect that was disproportional to the enhancing lesion were common findings in three patients. The other lesions seen on cranial CT could not be directly linked to HIV infection. CONCLUSION: Apart from the diffuse breakdown in blood brain barrier with disproportional mass effect, our findings were similar to previous reports. Further study with a larger population of patients and, especially, biopsy of the CNS lesion will be needed to confirm our findings.
Assuntos
Encefalopatias/diagnóstico por imagem , Encefalopatias/etiologia , Infecções por HIV/complicações , Adulto , Idoso , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Estudos Retrospectivos , Crânio/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND AND OBJECTIVE: Poverty, drug resistance and the advent of human immunodeficiency virus infection (HIV) have led to a recent upsurge in the incidence of tuberculosis including intracranial tuberculosis. In this article, we report 3 patients who had solitary brain tuberculomas and were otherwise healthy to underscore the importance of continuing vigilance for this disease. CASE REPORTS: Three patients (57 years, female; 52 years, male; 7 years male) presented to our unit with features of intracranial tumours. They were all HIV negative with no previous history of tuberculosis. Cranial computed tomography scans demonstrated uniformly contrast enhancing falcine supratentorial masses in the adult patients and a cerebellar hemispheric lesion with peripheral contrast enhancement in the paediatric patient INTERVENTION: All the patients had gross total tumour excision. The histology confirmed a tuberculoma. They all had antituberculous therapy after histological confirmation. The outcome was good in all the patients. CONCLUSION: Intracranial tuberculoma can occur in otherwise healthy individuals and should always be considered in the differential diagnosis of solitary intracranial mass lesions in sub-Saharan Africans so that minimally invasive procedures can be used to establish the correct diagnosis.
Assuntos
Cerebelo , Imunidade Celular , Tuberculoma Intracraniano/diagnóstico por imagem , Antituberculosos/uso terapêutico , Criança , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Tomografia Computadorizada por Raios X , Tuberculoma Intracraniano/imunologiaRESUMO
The well-known fact that history writers always seem wiser than the subjects on whom they write is the most logical inherent proof that history is rich in lessons. The history of Anatomy is not an exception. It is full of imperative lessons in the Art and Science of the discipline of Anatomy, which following generations ought to learn. We present a defined brief survey with this in mind.
El hecho bien conocido que los historiadores siempre parecen ser más sensatos que los sujetos sobre quienes escriben, es la más lógica prueba que la historia es rica en lecciones. La historia de la Anatomía no es la excepción. Ella está llena de lecciones imperativas en el arte y ciencia, de la cual generaciones venideras deberían aprender. Presentamos un breve reconocimiento sobre lecciones de la Historia de la Anatomía.
Assuntos
Humanos , História Antiga , História Medieval , História do Século XV , História do Século XVI , Anatomia/históriaRESUMO
An unusual case of malignant schwannoma with involvement of the forehead, external nose, right nasal cavity, paranasal sinus system (bilateral frontal sinus, right ethmoidal sinus), right orbit and anterior cranial fossa is reported in a Nigerian. Malignant schwannomas of the paranasal sinus are extremely rare, as only 20 well-documented cases have been previously published in English literature. No report in black Africans has been found in extant literature. The clinical features of this tumour are presented with detailed management. The patient had a wide surgical resection of the lesion with reconstruction of the resultant fronto-nasal defect using forehead musculofascial flap plus full thickness skin graft and adjuvant radiotherapy with satisfactory outcome. The good result of combined surgery and radiation regimens in this case demonstrates the usefulness of adjuvant radiation therapy in this condition.
Assuntos
Cavidade Nasal/patologia , Neurilemoma/diagnóstico , Neurilemoma/cirurgia , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/cirurgia , Neoplasias dos Seios Paranasais/diagnóstico , Neoplasias dos Seios Paranasais/cirurgia , Adolescente , Feminino , Humanos , Nigéria , Tomografia Computadorizada por Raios XRESUMO
Benign intracranial hypertension (BIH) may lead to blindness and rarely deafness. We describe the case of a rapidly deteriorating 14-year-old African girl who presented with headaches associated with complete visual and hearing loss due to BIH. This was managed non-operatively with lumbar cerebrospinal fluid tap, weight reduction, nicotinic acid and acetazolamide. Response to treatment was quite dramatic with resolution of severe headaches and regaining of light perception 8 days after commencing treatment. By 3 months hearing recovered to normal and there was resolution of vision. This to the best of our knowledge is the first reported case of complete visual and hearing loss occurring in a patient with BIH, which was managed successfully non-operatively. When indicated, non-operative management is an effective treatment option even in malignant BIH.
Assuntos
Cegueira/etiologia , Surdez/etiologia , Niacina/administração & dosagem , Pseudotumor Cerebral/complicações , Pseudotumor Cerebral/tratamento farmacológico , Vasodilatadores/administração & dosagem , Acetazolamida/administração & dosagem , Adolescente , Diuréticos/administração & dosagem , Feminino , Humanos , Recuperação de Função Fisiológica , Punção Espinal , Redução de PesoRESUMO
Spinal arteriovenous malformations (AVMs) being even rarer than cranial ones, constitute 3 - 4% of all spinal tumours, with an overall male:female ratio of 4:1. We report the case of a 24-year old female Youth Corps member who presented with an apoplectic onset of a left hemiparesis, progressively deteriorating to an incomplete quadriplegia with motor power of 2 and 0 in the right and left lower limb muscle groups, respectively. Magnetic resonance imaging (MRI) showed a vascular malformation whose precise nature was indeterminate; the definitive diagnosis of a Glomus AVM was only made intra-operatively. Laminectomy with complete surgical excision was done and she gradually improved to ambulate with minimal support. The experience in our unit tends to support the observation in literature that spinal arteriovenous malformations could be very rare, and depending on the location, could be amenable to complete surgical excision and recovery of neurological function.
Assuntos
Malformações Arteriovenosas/diagnóstico , Laminectomia , Doenças Vasculares da Medula Espinal/diagnóstico , Medula Espinal/anormalidades , Adulto , Malformações Arteriovenosas/cirurgia , Feminino , Humanos , Doenças Vasculares da Medula Espinal/cirurgiaRESUMO
BACKGROUND: There are no pathognomonic presenting features of intracerebral abscesses. Their clinical features could be confused with those of a tumour or any other space occupying lesion. STUDY DESIGN: We analyzed the symptoms, predisposing factors, diagnostic modalities, prevalent causative microbes, management and outcome in 11 patients, for whom complete records were available and who were managed for confirmed intracerebral abscess in our Neurosurgical Unit from 1996 to 2000 and compared our findings with those from other series. RESULTS: In these patients focal neurological deficit was the most common clinical feature, trauma was the most predisposing event and Computerised Tomography (CT) Scanning remained the most dependable diagnostic tool. In our practice, burr hole drainage augmented with a minimum of 4 weeks intravenous antibiotics, was the most frequently used treatment modality. CONCLUSION: The outcome was satisfactory (ability to return to pre-morbid activities and duties, with no disabling neurological deficits) in 72.8% cases. There was one death. This modality remains an effective way of treating patients with intracebrebral abscess.
Assuntos
Abscesso Encefálico/diagnóstico , Empiema Subdural/diagnóstico , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Idoso , Antibacterianos/uso terapêutico , Encéfalo/patologia , Abscesso Encefálico/microbiologia , Abscesso Encefálico/fisiopatologia , Abscesso Encefálico/terapia , Criança , Terapia Combinada , Diagnóstico Diferencial , Drenagem , Empiema Subdural/microbiologia , Empiema Subdural/fisiopatologia , Empiema Subdural/terapia , Feminino , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Resultado do TratamentoRESUMO
OBJECTIVES: To report an uncommon and a rare case of a high congenital spinal anomaly with an unusual presentation. METHODS: This is a case presentation with relevant radiological and operative findings. CONCLUSION: This lesion is a differential diagnosis of cystic congenital spinal mass lesions. This case is an example of a high congenital spinal lesion with very minimal or negligible neurological deficits, with no other congenital malformations.
Assuntos
Meningomielocele/diagnóstico , Vértebras Torácicas/anormalidades , Malformação de Arnold-Chiari/diagnóstico , Cistos/diagnóstico , Cistos/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Hidrocefalia/diagnóstico , Recém-Nascido , Masculino , Meningomielocele/cirurgia , Gravidez , Vértebras Torácicas/patologia , Vértebras Torácicas/cirurgiaRESUMO
Encephalocele is a common congenital problem in the practice of Neurosurgery worldwide, with varying sizes of the underlying skull defects. This study was carried out to determine the size of the problem; to assess whether the skull defects are being under-managed or not; and also to determine those patients that will benefit from cranioplasty. The case notes of the patients with encephalocele managed over a 5 year period were reviewed and the relevant data obtained. Seventy-six percent of the patients had occipital encephalocele. The average diameter of the skull defect was 1.8 cm. Only 2 (9.5%) of the patients had cranioplasty. Cosmesis was acceptable to all the patients. No recurrence was noted in the series studied. We therefore concluded that the skull defects are not being under-managed, however large anteriorly based lesions with wide skull defects (i.e >2.5 cm) will require cranioplasty.
Assuntos
Anormalidades Craniofaciais/complicações , Anormalidades Craniofaciais/cirurgia , Encefalocele/complicações , Pré-Escolar , Craniotomia/métodos , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Procedimentos de Cirurgia Plástica , Estudos Retrospectivos , Crânio/cirurgiaRESUMO
We conducted this study in order to determine whether suturing the scalp wound prior to referral for definitive surgery reduces the rate of wound infection in patients with compound depressed skull fracture and to propose guidelines for the initial management of the wound. We conducted a retrospective analysis of 79 patients with compound depressed skull fractures treated surgically in our unit between January, 1987 and August, 1998 and compared the rate of infection in patients who presented with open wounds with the rate in patients whose scalps were sutured prior to presentation to us. Adults and children were nearly equally represented in this study group. The male to female ratio was 3.6:1. Majority (49/79) of the fractures resulted from vehicular accidents. A total of 27 wounds were infected giving a rate of infection of 34%. Nine of the infections were present pre-operatively while the remaining 18 occurred post-operatively. Of the 52 patients with open wounds (OW) at presentation, 15 had wound infection. In the remaining 27 patients in whom the scalp had been sutured prior to referral (SW), there were 12 wound infections. There was no significant difference in the proportions of infected wounds between the two groups (X2 = 1.92, P > 0.5). In compound depressed skull fractures, suturing the scalp laceration alone prior to referral for definitive surgery did not reduce the rate of infection of the cranial wound. We recommend haemostasis, thorough irrigation of the scalp wound and application of sterile dressings prior to transfer for definitive management, in patients who do not have immediate access to neurosurgical care. Prospective studies are required to validate these findings.