RESUMO
In this paper, we analyzed our own results and published data on the expression of regulatory genes encoding transcription factors Pax6/PAX6, Pitx2/PITX2, Fox1/FOXC1, Prox1/PROX1, Oct4/OCT4, Nanog/NANOG, and TGFß2 signaling protein during morphogenesis of the cornea in vertebrates. We considered the results obtained for the cornea of model animals, primarily mice, and human fetal cornea. The main possibility of establishing common mechanisms of eye development in vertebrates in health and disease is comparative studies of eye morphogenesis of humans and animal models.
Assuntos
Córnea/embriologia , Córnea/crescimento & desenvolvimento , Regulação da Expressão Gênica no Desenvolvimento , Animais , Córnea/fisiologia , Proteínas do Olho/genética , Fatores de Transcrição Forkhead/genética , Proteínas de Homeodomínio/genética , Humanos , Camundongos , Morfogênese/genética , Proteína Homeobox Nanog , Fator 3 de Transcrição de Octâmero/genética , Fator de Transcrição PAX6 , Fatores de Transcrição Box Pareados/genética , Proteínas Repressoras/genética , Fatores de Transcrição/genética , Fator de Crescimento Transformador beta2/genética , Proteínas Supressoras de Tumor/genética , Vertebrados/genética , Vertebrados/crescimento & desenvolvimento , Proteína Homeobox PITX2RESUMO
Expression of transforming growth factor-ß2 was detected by PCR in the vitreous body, lens, retina, and ciliary-iris complex of human eye at early stages of fetal development. Immunochemical assay of the corresponding protein in eye tissues revealed a correlation between the localization of transforming growth factor-ß2 and the development of intraocular hyaloid vascular network, its regression, formation of the vitreous body, and development of definite retinal vessels.