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2.
Clin Exp Dermatol ; 43(8): 876-882, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29756221

RESUMO

BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) represents the most common form of skin cancer after basal cell carcinoma, and can be both locally invasive and metastatic to distant sites. Growth rate (GR) has been poorly evaluated in cSCC, despite clinical evidence suggesting that GR is an important risk factor in cSCC. AIM: To analyse the influence of GR in cSCC prognosis. METHODS: We retrospectively evaluated GR in a series of 90 cSCCs and tried to correlate GR with prognosis in cSCC. RESULTS: We demonstrated that tumours with a GR of > 4 mm/month exhibit a higher risk of nodal progression and a shorter progression time to lymph node metastasis in cSCC than those with GR of < 4 mm/month. As expected, GR correlated with tumour proliferation, as determined by Ki-67 expression. CONCLUSIONS: We consider a GR of 4 mm/month as the cutoff point that distinguishes between rapid- and slow-progressing tumours and, more importantly, to identify a subset of high-risk cSCCs.


Assuntos
Carcinoma de Células Escamosas/patologia , Progressão da Doença , Neoplasias Cutâneas/patologia , Idoso , Idoso de 80 Anos ou mais , Antígenos de Superfície/metabolismo , Feminino , Humanos , Modelos Logísticos , Metástase Linfática , Masculino , Prognóstico , Estudos Retrospectivos , Fatores de Risco
3.
Acta Neurochir (Wien) ; 150(2): 119-27; discussion 127, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18176776

RESUMO

BACKGROUND: There is general consensus that a successful endoscopic third ventriculostomy is usually followed by a decrease of ventricular size without reaching their normal size. This study was performed to determine how the change related to clinical outcome, how it developed chronologically and whether the change in ventricular size was different in acute and chronic forms of hydrocephalus. METHOD: Fifty-five of 74 patients who had undergone endoscopic third ventriculostomy during the period 1997-2004 were selected by the criterion that they had both pre-operative and post-operative films and no neurosurgical manoeuvre other than a surgically successful endoscopic third ventriculostomy in the time span between both radiological studies. Ventricular size was measured with the Evans index, third ventricle index, cella media index and ventricular score. Median age was 51 years (interquartile range, 27-65 years). RESULTS: The change in ventricular size detected shortly after surgery is related to clinical outcome for all ventricular ratios, except the cella media index (p = 0.08). When third ventriculostomy is clinically successful, there is a gradual decrease of ventricular size over a period of more than three months (p < 0.0001 for all ventricular ratios). The reduction is more prominent in acute hydrocephalus than in chronic forms for all ventricular ratios, except the Evans index (p = 0.12). The third ventricle exhibits the greatest reduction (25% with a 95% confidence interval: 15.4-34.5) and determines a different pattern of change in ventricular size after endoscopic third ventriculostomy between acute and chronic hydrocephalus. CONCLUSIONS: A decrease of the ventricular size detected soon after endoscopic third ventriculostomy is associated with a satisfactory clinical outcome. This response continues during the first few months after surgery. The reduction is more prominent in acute forms of hydrocephalus.


Assuntos
Endoscopia , Hidrocefalia/cirurgia , Terceiro Ventrículo/patologia , Terceiro Ventrículo/cirurgia , Ventriculostomia , Doença Aguda , Adulto , Idoso , Doença Crônica , Feminino , Seguimentos , Humanos , Hidrocefalia/diagnóstico , Hidrocefalia/etiologia , Masculino , Pessoa de Meia-Idade , Tamanho do Órgão , Fatores de Tempo , Resultado do Tratamento
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