Surgical nursing care in the operating room: an integrative review / Cuidado cirúrgigo de enfermagem em salas de cirurgia: uma revisão integrativa / Cuidado quirúrgico de enfermería de sala de operaciones: una revisión integrativa

ABSTRACT Objective: to identify the state-of-the-art developed about surgical Nursing care in the operating room. Method: an integrative review with search and selection of primary studies conducted in April and May 2022 in four major data sources in the health field, namely: LILACS, SciELO, BDENF and PubMed, from 2018 to 2022. The sample consisted of 13 studies, 8 selected from a universe of 293 articles and 5 obtained through the manual search. Results: three categories were generated: Associating surgical care with care, people and material resources management for patient safety; Surgical care and ethical sensitivity in the search for patients' well-being; and Operating room nurses' manifestation and omission experiences and surgical care. Conclusions: surgical Nursing care in the operating room is varied and is manifested through meeting the administrative demands, ethical sensitivity, body temperature maintenance, preservation of individuality and meeting all the needs in the intraoperative period when patients are more vulnerable, including being duly informed as a way to provide safe surgical care. On the other hand, nurses acknowledge the need to change their world view and direct surgical care towards a more human, social and cultural perspective.

RESUMO Objetivo: identificar o estado da arte que foi desenvolvido sobre os cuidados cirúrgicos do enfermeiro da sala de cirurgia. Método: revisão integrativa com pesquisa e seleção de estudos primários realizada entre abril e maio de 2022 em quatro fontes de dados destacadas no campo da saúde: LILACS, SciELO, BDENF e PubMed de 2018 a 2022. A amostra consistiu-se de 13 estudos, 8 selecionados de um total de 293 artigos e 5 pesquisados manualmente. Resultados: foram geradas três categorias: associação do cuidado cirúrgico com a gestão dos cuidados, pessoas e recursos materiais para a segurança do paciente; cuidado cirúrgico e sensibilidade ética na busca do bem-estar do paciente e as experiências de manifestação e omissão do enfermeiro da sala de cirurgia e o cuidado cirúrgico. Conclusões: o cuidado cirúrgico na sala de cirurgia é variado e se manifesta através da atenção às exigências administrativas, sensibilidade ética, manutenção da temperatura corporal, preservação da individualidade e atenção a todas as necessidades no ambiente intra-operatório onde o paciente é mais vulnerável, incluindo o dever de estar informado como um meio de proporcionar um cuidado cirúrgico seguro. Por outro lado, reconhece a necessidade de mudar sua cosmovisão e direcionar os cuidados cirúrgicos para uma perspectiva mais humana, social e cultural.

RESUMEN Objetivo: identificar el estado de arte que se ha desarrollado sobre el cuidado quirúrgico de la enfermera de sala de operaciones. Método: revisión integrativa con indagación y selección de estudios primarios efectuada en abril y mayo de 2022 en cuatro fuentes de datos destacadas en el campo de la salud: Lilacs, SciELO, BDENF y PubMed de 2018 a 2022. La muestra se conformó por 13 estudios, 8 seleccionados de un universo de 293 artículos y 5 de búsqueda manual. Resultados: se generaron tres categorías: asociando cuidado quirúrgico con gestión de cuidado, de personas y de recursos materiales para la seguridad del paciente; el cuidado quirúrgico y la sensibilidad ética en la búsqueda de bienestar para el paciente y las experiencias de manifestación y omisión del enfermero de quirófano y el cuidado quirúrgico. Conclusiones: el cuidado quirúrgico en la enfermera de sala de operaciones es variado y se manifiesta a través de la atención a las demandas administrativas, la sensibilidad ética, el mantenimiento de la temperatura corporal, conservación de la individualidad y atención a todas las necesidades en el intraoperatorio donde el paciente es más vulnerable, incluyendo el estar informada como una forma de brindar un cuidado quirúrgico seguro. Por otro lado, reconoce la necesidad de cambiar su visión de mundo y dirigir el cuidado quirúrgico hacia una mirada más humana, social y cultural.

Eligibility criteria for Menopausal Hormone Therapy (MHT): a position statement from a consortium of scientific societies for the use of MHT in women with medical conditions. MHT Eligibility Criteria Group.

This project aims to develop eligibility criteria for menopausal hormone therapy (MHT). The tool should be similar to those already established for contraception A consortium of scientific societies coordinated by the Spanish Menopause Society met to formulate recommendations for the use of MHT by women with medical conditions based on the best available evidence. The project was developed in two phases. As a first step, we conducted 14 systematic reviews and 32 metanalyses on the safety of MHT (in nine areas: age, time of menopause onset, treatment duration, women with thrombotic risk, women with a personal history of cardiovascular disease, women with metabolic syndrome, women with gastrointestinal diseases, survivors of breast cancer or of other cancers, and women who smoke) and on the most relevant pharmacological interactions with MHT. These systematic reviews and metanalyses helped inform a structured process in which a panel of experts defined the eligibility criteria according to a specific framework, which facilitated the discussion and development process. To unify the proposal, the following eligibility criteria have been defined in accordance with the WHO international nomenclature for the different alternatives for MHT (category 1, no restriction on the use of MHT; category 2, the benefits outweigh the risks; category 3, the risks generally outweigh the benefits; category 4, MHT should not be used). Quality was classified as high, moderate, low or very low, based on several factors (including risk of bias, inaccuracy, inconsistency, lack of directionality and publication bias). When no direct evidence was identified, but plausibility, clinical experience or indirect evidence were available, "Expert opinion" was categorized. For the first time, a set of eligibility criteria, based on clinical evidence and developed according to the most rigorous methodological tools, has been defined. This will provide health professionals with a powerful decision-making tool that can be used to manage menopausal symptoms.

Osteomielitis crónica agudizada del maxilar. Presentación de un caso pediátrico / Acute chronic osteomyelitis of the maxilla. Presentation of pediatric case / Osteomielite crônica aguda da maxila. Apresentação de um caso pediátrico

RESUMEN Se presentó el caso de una paciente femenina de 9 años con historia de traumatismo a nivel de incisivos centrales superiores, por lo cual recibió tratamiento para apicoformación con hidróxido de calcio durante un periodo prolongado, que luego de realizarle la obturación de los conductos radiculares presentó un cuadro de inflamación aguda en labio superior y vestíbulo bucal. El tratamiento incluyó terapia antimicrobiana, desbridamiento quirúrgico amplio bajo anestesia general, apicectomía de ambos incisivos, obturación a visión directa de los conductos y sellado apical de los dientes con gutapercha. El diagnóstico anatomopatológico fue el de osteomielitis crónica agudizada del maxilar. Año y medio después se observó ausencia clínica de signos inflamatorios y adecuada cicatrización del tejido óseo. Se concluyó que, aunque los reportes de osteomielitis crónica del hueso maxilar son escasos, debe estar presente dentro del diagnóstico diferencial cuando se evalúan pacientes en edad pediátrica con historia de traumatismo dentoalveolar y procesos inflamatorios en la región maxilofacial.

ABSTRACT A nine-year old female patient presented with a history of trauma to the upper central incisors. She received treatment for apicoforming with calcium hydroxide for a prolonged period, who after root canal obturation presented acute inflammation of the upper lip and buccal vestibule. Treatment included antimicrobial therapy, extensive surgical debridement under general anesthesia, apicoectomy of both incisors, and direct visual obturation of the canals and apical sealing of the teeth with gutta-percha. The anatomopathologic diagnosis was acute chronic osteomyelitis of the maxilla. One and a half years later, clinical absence of inflammatory signs and adequate healing of the bone tissue were observed. It was concluded that, although reports concerning chronic osteomyelitis of the maxillary bone are rare events, this type of infection should be always present at the time of the differential diagnosis for evaluating pediatric patients with a history of dentoalveolar trauma and inflammatory processes in the maxillofacial region.

RESUMO Apresentamos o caso de uma paciente feminina de 9 anos de idade com histórico de trauma nos incisivos centrais superiores, para a qual ela recebeu tratamento para apicoformação com hidróxido de cálcio por um período prolongado, que após a obturação do canal radicular apresentou inflamação aguda do lábio superior e vestíbulo vestibular. O tratamento incluiu terapia antimicrobiana, desbridamento cirúrgico extensivo sob anestesia geral, apicoectomia de ambos os incisivos, obturação visual direta dos canais e vedação apical dos dentes com guta-percha. O diagnóstico patológico foi uma osteomielite crônica aguda da maxila. Um ano e meio depois, houve uma ausência clínica de sinais inflamatórios e uma cicatrização adequada do tecido ósseo. Concluiu-se que, embora os relatos de osteomielite crônica do osso maxilar sejam escassos, ela deveria estar presente no diagnóstico diferencial ao avaliar pacientes pediátricos com histórico de trauma dentoalveolar e processos inflamatórios na região maxilofacial.

When Is Sentinel Node Biopsy Indicated in High-Risk Ductal Carcinoma in situ? Four Hundred Sixty-Eight Cases from Three Institutions.

INTRODUCTION: Sentinel lymph node biopsy (SLNB) in ductal carcinoma in situ (DCIS) is not indicated. However, in certain cases (size >3 cm, high grade, mass effect on mammography, or palpable mass), it may be possible to find incidental invasive carcinoma (IC) that requires an SLNB. We studied the correlation of the aforesaid factors with the probability of finding IC in the surgical specimen. METHODS: Data was collected from 3 different institutions between 2010 and 2016, recording characteristics such as, but not limited to: high grade, size >3 cm, mass effect on mammography, and palpable mass. RESULTS: On the whole, 468 "high-risk" DCIS cases were identified, 139 (29%) of which had IC. When the DCIS was high grade or the size was >3 cm, there was no significant difference in the probability of finding IC in the surgical specimen (OR = 1.13; 95% CI 0.84-1.51; OR = 1.2; 95% CI 0.85-1.40). Nevertheless, when a high grade and size (>3 cm) were combined, IC was more likely to exist (72.7 vs. 27.3%; p = 0.001). In addition, mass effect and palpation were independently associated with a significantly greater degree of IC (OR = 12.76; 95% CI 6.93-23.52). CONCLUSIONS: The results suggest that high-grade DCIS or DCIS with a size >3 cm, independently, does not require SLNB. Nonetheless, in the event that both factors are found in the same case, SLNB may be indicated. Additionally, SLNB is advisable for DCIS cases that are palpable or show a mass effect on mammography.

Una mirada fenomenológica social al cotidiano de la gestión de la enfermera jefa de servicio / A Phenomenological Approach to the Daily Management Practice in the Head Nurse of the Service

Introducción: La inquietud surge como enfermera asistencial, percibiendo el trabajo diario de la enfermera jefa de servicio como sobrecargado y estresante. Está relacionado al quehacer cotidiano de la enfermera jefa, un área poco investigada. Objetivo: Comprender el cotidiano de la gestión de la enfermera jefa de servicio. Métodos: El abordaje teórico metodológico fue la fenomenología social de Alfred Schütz. El escenario, el Hospital Central de la Fuerza Aérea del Perú en el año 2018 a 2019. La muestra, conformada por diez enfermeras jefes de servicio, seleccionadas mediante saturación de discursos, utilizándose como técnica de recolección de datos la entrevista fenomenológica, como instrumento una guía de entrevista y para el análisis de los datos se utilizó el análisis temático. Resultados: Se generaron 2 categorías: "Asumiendo la responsabilidad y el liderazgo en la gestión del cotidiano de un servicio de Enfermería" y "Compartiendo intersubjetividades al interactuar con otros semejantes en el mundo de vida cotidiano". Conclusiones: La enfermera jefa de servicio en la gestión de su cotidiano tiene muy arraigado el sentido de responsabilidad atribuido al cargo, interactúa no solo con el equipo de enfermería, sino también con médicos y autoridades militares, encuentra muchas veces dificultades en hacerles entender las necesidades del servicio, sin embargo, en el cotidiano maneja estas intersubjetividades mediante su acervo de conocimientos(AU)

Introduction: The concern arises in the practice as a nurse, perceiving the daily work of the head nurse of the service as overloaded and stressful. It is associated with the daily work of the head nurse, an area little investigated. Objective: To understand the daily practice of the head nurse of the service. Methods: The theoretical-methodological approach was Alfred Schütz's social phenomenology. The setting was the Central Hospital of the Peruvian Air Force in the year 2018 to 2019. The sample was made up of ten service chief nurses, selected through saturation of speeches, using the phenomenological interview as a data collection technique; as an instrument, an interview guide was used and thematic analysis was used for data analysis. Results: Two categories were generated: "Assuming responsibility and leadership in the daily practice of a nursing service" and "Sharing intersubjectivities when interacting with other peers in the world of daily practice". Conclusions: The head nurse of the service, in the management of her daily practice, has a deep-rooted sense of responsibility attributed to the position. She interacts not only with the nursing team, but also with doctors and military authorities, often coming across difficulties in making them understand their needs. However, in everyday practice, the head nurse handles these intersubjectivities through her or his wealth of knowledge(AU)

Caracterización clínica-epidemiológica de la hipertensión arterial / Clinical-epidemiological characterization of arterial hypertension

Introducción: La hipertensión arterial constituye uno de los problemas médicos más importantes de la medicina contemporánea en los países desarrollados y se le ha denominado la plaga silenciosa del Siglo XXI. Objetivo: Caracterizar clínica y epidemiológicamente la hipertensión arterial en pacientes hipertensos. Métodos: Se realizó un estudio observacional, descriptivo, de corte longitudinal prospectivo. El universo estuvo constituido por 193 pacientes hipertensos de la población del consultorio 7 del Policlínico: Aleida Fernández Chardiet, en el período comprendido entre enero y diciembre del año 2017. Se utilizaron distribuciones de frecuencias, cálculos porcentuales y medidas de tendencia central. Resultados: Del total de pacientes, 48,7 por ciento pertenecía al grupo de edad 40 y 59 años. Predominaron las féminas (112/58,03 por ciento) y los pacientes de piel negra (36,8 por ciento). El factor de riesgo modificable que predominó fue el tabaquismo, presente en 62,7 por ciento 55,4 por ciento presentó cifras de tensión arterial controladas. La mayoría usaba 2 fármacos antihipertensivos (44,6 por ciento). Conclusiones: La hipertensión arterial en el adulto es mejor controlada a menor edad y cuando se utilizan dos fármacos. El principal factor de riesgo de los hipertensos fue el tabaquismo(AU)

Introduction: Hypertension is one of the most important medical problems of contemporary medicine in developed countries and it has been named the silent plague of the twenty-first century. Objective: To describe clinical and epidemiologically arterial hypertension in hypertensive patients. Methods: An observational, descriptive and prospective longitudinal study was carried out. The sample was of 193 hypertensive patients of the population belonging to the Family Doctor's office num. 7, Aleyda Fernández Chardiet Teaching Polyclinic, in the period between January and December, 2017. Frequency distributions, percentage calculations and measures of central tendency were used. Results: Of the total number of patients, 48.7 percent belonged to the age group from 40 to 59 years. There was a predominance of females (112; 58.03 percent) and patients with black skin (36.8 percent). The predominant modifiable risk factor was smoking habit that was present in the 62.7 percent; while the 55.4 percent presented controlled blood pressure´s numbers. Most of the patients used two antihypertensive drugs (44.6 percent). Conclusions: Hypertension in adults is better controlled at a lower age and when using two drugs. The main risk factor of hypertensive patients was smoking habit(AU)

Factores determinantes de la lactancia materna exclusiva: Policlínico "Aleida Fernández". 2015 / Determinant factors of exclusive breastfeeding. "Aleida Fernández" Polyclinic. 2015

Introducción: La historia de la lactancia materna es tan antigua como la historia de la humanidad. La leche materna ha sido durante toda la existencia del ser humano el único alimento que el recién nacido y el lactante pequeño podían recibir para sobrevivir. En Cuba en 2014 se pudo apreciar que 33,2 por ciento de los infantes menores de 6 meses eran amamantados con lactancia materna exclusiva. Objetivo: Caracterizar el comportamiento de la lactancia materna exclusiva, según factores biosociales en el Policlínico Docente Aleida Fernández Chardiet del municipio La Lisa, en 2015. Material y Métodos: Se realizó un estudio observacional descriptivo, de corte transversal. El universo de estudio lo constituyeron 182 madres de niños nacidos durante esa etapa en el área de salud. Se realizaron distribuciones de frecuencia y cálculos porcentuales. Resultados: El 49,5 por ciento de madres mantuvo lactancia materna exclusiva por 6 meses. Solo 34,2 por ciento de madres con nivel de escolaridad de secundaria, mantuvo la lactancia materna exclusiva por 6 meses. Conclusiones: Casi la mitad de las madres mantuvieron la lactancia materna exclusiva por 6 meses. En las madres en que la lactancia materna exclusiva duró menos de 6 meses, predominaron los siguientes factores biosociales: edad menor de 20 años, nivel de escolaridad de secundaria, estudiantes, primíparas, solteras y las de familia severamente disfuncionales. La insuficiente disponibilidad de leche en las mamas fue la la causa más frecuente de supresión de la lactancia materna exclusiva(AU)

Introduction: The history of breastfeeding is as old as the history of mankind. Breast milk has been the only food that the newborn and the small infant could receive to survive during all the existence of the human being. It was observed that 33,2 percent of the infants younger than 6 months received exclusive breastfeeding in Cuba, in 2014. Objective: To characterize exclusive breastfeeding behavior according to biosocial factors in Aleida Fernández Chardiet Teaching Polyclinic, La Lisa Municipality, in the year 2015. Material and Methods: A cross-sectional descriptive observational study was conducted. The universe of study was composed of 182 mothers of children who were born in the health area during the study period. Distribution of frequencies, and percentage calculations were carried out. Results: 49,5 percent of mothers maintained exclusive breastfeeding for 6 months. Only 34,2 percent of mothers with secondary school education maintained exclusive breastfeeding for 6 months. Conclusions:Almost half the mothers maintained exclusive breastfeeding for 6 months. The following biosocial factors predominate in those mothers in whom exclusive breastfeeding lasted less than 6 months: younger than 20 years of age, secondary school education, students, primiparas, single, and mothers from severe dysfunctional families. Insufficient milk availability in the breasts was the most frequent cause of breastfeeding suppression(AU)

Manejo obstétrico de la deficiencia hereditaria de antitrombina durante el embarazo y puerperio. Dos casos clínicos / Obstetric management of hereditary antithrombin deficiency in pregnancy and postpartum. Two case studies

La deficiencia de antitrombina III hereditaria es una rara enfermedad que afecta al 0.02-0.2 por cento de la población. Puede presentar mayor frecuencia de complicaciones y resultados adversos tanto en la madre como en el feto. Se presenta el manejo obstétrico de dos gestaciones consecutivas en una mujer con deficiencia de antitrombina III. Descripción: en ambos embarazos la madre realiza profilaxis de la enfermedad tromboembólica con heparina de bajo peso molecular para evitar la aparición de esta patología tanto en el embarazo como en el puerperio y mejorar el flujo útero-placen-tario. Con respecto a las complicaciones obstétricas, sólo existe un enlentecimiento del crecimiento fetal que obliga a un control obstétrico estricto. En ambas gestaciones los estudios eco-Doppler están dentro de la normalidad lo que permite una conducta expectante, consiguiendo llegar a término. Discusión: la profilaxis con heparina de bajo peso molecular en las gestantes con esta trombofilia y las intervenciones preventivas de factores de riesgo de enfermedad tromboembólica, junto con un control obstétrico adecuado, ha conseguido evitar la apari-ción de complicaciones derivadas de esta patología en el embarazo y en el puerperio. Por otra parte, el control del crecimiento fetal y el estudio Eco-Doppler han permitido asegurar el bienestar fetal no adelan-tando el parto, consiguiendo partos a término...

Hereditary antithrombin III deficiency is a rare disease that affects 0.02-0.2 percent of the population. It may be associated with a higher rate of complications and adverse outcomes in both mother and fetus. The present study describes the management of a woman with antithrombin III deficiency and two consecutive pregnancies. Description: in both pregnancies, the woman under went prophylaxis with low molecular weigh heparin, to prevent thromboembolic disease and improve the utero-placental flow during pregnancy and the postpartum period. The only obstetric compli-cation was fetal growth retardation requiring strict obstetric control. In these two cases the eco-Doppler studies offeto-placentalflow were normal, leading to the expectation of managing a term birth. Discussion: low molecular weigh heparin prophylaxis in pregnant women with thrombophilia and preventive interventions for risk factors for throm-boembolic disease, together with appropriate obstetric care managed to avoid the emergence of complications of this disease in pregnancy and puer-perium. Fetal growth control and a Doppler study also help to ensure the well-being of the fetus and avoid a preterm birth...

Piometra por Streptococcus agalactiae tras parto vaginal eutócico. Presentación de un caso y revisión de la literatura / Streptococcus agalactiae pyometra following eutocic vaginal delivery. Case presentation and review of the literature

Objetivo: analizar un caso clínico de piometra por Streptococcus agalactiae tras parto vaginal. Revisar los factores de riesgo, el diagnóstico y el tratamiento de esta entidad. Materiales y métodos: se presenta el caso de una puérpera de 35 años con cuatro partos anteriores y parto vaginal diez días antes, quien consulta por sangrado genital abundante al Hospital Universitario San Cecilio de Granada (España) que realiza la atención obstétrico-ginecológica de la población sur de Granada y es centro de referencia de los Hospitales Básicos del Área Sanitaria Sur de la provincia. La ecografía transvaginal muestra cavidad uterina ocupada por contenido heterogéneo. Se practica legrado obteniéndose abundante material purulento, se hace diagnóstico de piometra y se instaura tratamiento antibiótico de amplio espectro. Cultivo positivo para Streptococcus agalactiae. Posteriormente presenta recidiva que precisa drenajes y tratamiento antibiótico intravenoso con clindamicina e imipenem, con buena evolución. Se realiza una búsqueda bibliográfica en las bases de datos: Pubmed, Cochrane y UpToDate utilizando los términos de búsqueda piometra posparto, endometritis posparto, Streptococcus agalactiae. Resultados: se encontraron 833 artículos en las bases de datos, de los cuales se seleccionaron 40 sobre casos de piometra o endometritis posparto en humanos incluyendo finalmente 14 artículos, 3 correspondieron a casos clínicos y 11 a revisiones del tema. Conclusiones: la aparición de piometra tras un parto vaginal eutócico es poco frecuente en humanos, pero debe considerarse como posible entidad etiológica en casos de fiebre puerperal con factores de riesgo asociados. El diagnóstico se basa en una buena exploración clínica y ecográfica, y se debe instaurar de forma precoz un tratamiento antibiótico de amplio espectro y realizar drenaje del mismo

Objective: To analyze a clinical case of rarely ocurring pyometra associated to Streptococcus agalactiae, after vaginal delivery and to review risk factors, diagnosis and treatment. Materials and methods: Case seen at the San Cecilio University Hospital in Granada (Spain), which provides obstetric and gynecological services to the population of southern Granada and is a referral center for the primary care hospitals of the southern provincial health district. The patient is a 35 year-old woman, parity 4, who assisted to the hospital, ten days ten days after eutocic vaginal delivery, with a clinical picture consistent with pyometra. On transvaginal ultrasound, the uterine cavity appeared occupied by heterogeneous content. Dilatation and curettage were performed with retrieval of abundant purulent material, and treatment with broad-spectrum antibiotics was instituted. The culture was positive for Streptococcus agalactiae. Pyometra reappeared at a later date, requiring drainage and intravenous treatment with clyndamicin and imipenem, with a good outcome. A literature search was conducted in the Pubmed, Cochrane and UpToDate databases using the terms pyometra, post-partum, endometritis, Streptococcus agalactiae. Results: Of 833 articles found in the databases, 40 with cases of pyometra or postpartum endometritis in humans were selected. Of these, 14 articles were finally selected, including 3 that described clinical cases and 11 topic reviews. Conclusions: The occurrence of pyometra after eutocic vaginal delivery is rare in humans, but must be considered as a potential etiology in cases of post-partum fever with associated risk factors. The diagnosis is based on good clinical and ultrasound examination, and the condition requires early treatment with broad-spectrum antibiotics and drainage

Analysis of perinatal mortality in newborn infants with a birth weight of less than 1000 grams in Hospital San Cecilio in Granada (Spain) over the 1991-2010 period / Análisis de la mortalidad perinatal en nacidos con peso menor de 1000 gramos en el Hospital San Cecilio de Granada (España) durante el período 1991-2010

Introduction. Perinatal mortality has significantly decreased over the last decades. Low birth weight and prematurity are amongst the strongest predictors of neonatal death. The main objective is to analyze the evolution of perinatal mortality and its causes in newborn infants with a birth weight of less than 1000 grams over the last 20 years (1991-2010). Population and Methods. Observational, descriptive, longitudinal and ecological study. A total of 264 infants weighing less than 1000 g out of a total of 56 024 births during the study period. Different specific perinatal mortality rates by weight were calculated. The Spearman's Rho correlation coefficient was applied to assess the relationship between mortality rates and years of study, and ANOVA and Mann-Whitney test were used to compare five-year periods and ten-year periods, respectively. Results. There were 131 perinatal deaths, 82 stillbirths and 49 early neonatal deaths; 64.1% of them occurred before 27 weeks of gestation. Only the fetal mortality rate was statistically significant, although perinatal mortality showed a downward trend, without reaching significance. The main immediate causes of death were extreme prematurity, intrauterine hypoxia and infection. The underlying causes related to death in this group of newborn infants were infection caused by premature rupture of membranes, maternal hypertension, uncontrollable preterm labor and twin pregnancy. Conclusions. The reduction in mortality rates in this group of newborn infants is undergoing a slowdown.

Introducción. La mortalidad perinatal ha disminuido sustancialmente en las últimas décadas. La prematuridad y el bajo peso al nacer son los factores predictivos más fuertemente asociados a esta mortalidad. El objetivo es analizar la evolución de la mortalidad perinatal en los nacidos con peso menor de 1000 g en los últimos 20 años (1991-2010) y sus causas. Población y métodos. Estudio observacional-descriptivo de tipo ecológico longitudinal, sobre 264 nacidos con peso menor de 1000 g de un total de 56 024 nacidos durante el período estudiado. Se calculan las diferentes tasas de mortalidad perinatal específicas por peso. Se aplica el coeficiente de correlación Rho de Spearman para evaluar la relación entre las tasas de mortalidad y los años de estudio, y las pruebas ANOVA y de Mann- Whitney para comparación de quinquenios y decenios, respectivamente. Resultados. Se han producido 131 muertes perinatales, 82 de ellas muertes fetales y 49 neonatales precoces. El 64,1% sucede antes de la semana de gestación 27. Sólo la tasa de mortalidad fetal presenta una disminución estadísticamente significativa, aunque la mortalidad perinatal presenta una tendencia al descenso, pero sin alcanzar la significación. Las principales causas inmediatas de óbito son la inmadurez extrema, la hipoxia intrauterina y la infección. Las causas fundamentales relacionadas con la muerte de este grupo de nacidos son la infección por rotura prematura de membranas, la hipertensión materna, la amenaza de parto pretérmino incontrolable y la gemelaridad. Conclusiones. La disminución de las tasas de mortalidad en este grupo de nacidos está sufriendo un enlentecimiento.

Surgical procedures before and after starting chronic hemodialysis in a predominantly male population with high prevalence of diabetes.

PURPOSE: The purposes of this study were to analyze changes in the frequency of different categories of surgical procedures after initiation of chronic hemodialysis (HD) and to identify the types of procedures associated with in-hospital postoperative mortality. METHODS: This was a retrospective analysis of surgical procedures performed in an incident HD population of 392 patients followed in the dialysis unit of one hospital over 15 years. Among these patients, 384 were men and 258 had diabetes mellitus. At the start of HD, age of the patients was 66.3 ± 11.2 years and Charlson index 5.35 ± 2.41. Rates of procedures per patient year (n/[pt-yr]), reported as mean (95% Confidence Interval [CI]), were compared by nonparametric methods. RESULTS: In the whole HD population, the overall rate of procedures increased in the HD period (pre-HD 0.125 [95% CI 0.101-0.149] n/[pt-yr]; HD 0.928 [95% CI 0.795-1.061] n/[pt-yr]; p<0.001). The increase, noted in patients with and without diabetes, reflected increases in the rates for both vascular access and non-vascular access procedures from the pre-HD to the HD period. Amputations and surgery for hip fractures accounted for the increase in the rates of procedures related to non-vascular access. Procedures associated with mortality in the HD period included amputations, hip repair and abdominal surgery for septic conditions. CONCLUSIONS: Rates of surgical procedures for vascular access, amputations, and hip fractures ?increased after the start of HD. Amputations and hip fractures, both potentially preventable, are associated with mortality in HD patients.

Hospitalizations before and after initiation of chronic hemodialysis.

Hospitalization rate is high in patients on chronic hemodialysis (HD). We investigated whether initiation of HD changes the rate and length of hospitalization. We analyzed hospitalizations in HD patients in one hospital over 15 years. We compared annual rate and length of hospitalizations, both presented as mean (95% confidence interval [CI]) between the pre-HD and HD period. Three hundred ninety-two patients, 98% men, 59% diabetic, and 66.3 ± 11.2 years old at the onset of HD, had 1016 hospitalizations in the pre-HD period (60.0 ± 42.9 months) and 1627 hospitalizations in the HD period (32.5 ± 25.9 months). Higher values were found in the HD than the pre-HD period for rate, (pre-HD 0.557 [95% CI 0.473-0.611], HD 2.198 [95% CI 1.997-2.399] admissions/[patient-year], P<0.001) and length (pre-HD 4.63 [95% CI 3.71-5.55], HD 28.07 [95% CI 23.55-32.59] days/patient-year], P<0.001) of hospitalizations for all causes, cardiac disease, infections, vascular access, peripheral vascular disease, metabolic disturbances, gastrointestinal diseases, and miscellaneous conditions, mainly respiratory illness and malignancy. Similar differences were found when we compared the year before and the year after the start of HD. Diabetics had higher all cause rate and length of hospitalizations than non-diabetics in the pre-HD and HD periods. The rate and length of hospitalizations was higher in the HD than the pre-HD period for both HD-specific conditions and conditions encountered in both HD and general populations. Study of factors specific to HD that may affect these conditions should constitute the first step toward improving the morbidity of patients on HD.

Hospital admissions in elderly patients on chronic hemodialysis.

BACKGROUND: The purpose of this study was to determine whether number of hospital admissions per patient per year (n/[pt-yr]) and hospital days per patient per year (d/[pt-yr]) differ between elderly and younger patients on chronic hemodialysis (HD). PATIENTS AND METHODS: In a retrospective cohort analysis of incident HD patients in one dialysis unit over 15 years, we compared 166 HD patients older than 70 years (77.1 ± 4.7 yrs) at the onset of HD (group A) and 216 patients younger than 70 years both at onset (57.1 ± 7.6 yrs) and at the end of the HD period (group B). Eighty (48.2%) of group A and 141 (65.3%) patients of group B had diabetes mellitus. RESULTS: No differences were noted in the overall hospitalization rate, presented as mean, {95% Confidence interval} (group A 2.40 {2.04-2.75}, group B 2.03 {1.89-2.16} n[pt-yr]) and days/[pt-year] (group A 33.6 {25.3-41.8}, group B 24.1 {18.9-29.23}). Group A had higher number of hospitalization days (P = 0.012) for surgery or trauma and higher rate (P = 0.045) and days (P = 0.041) of hospitalization for miscellaneous causes, primarily pulmonary disease, or malignancy. Among diabetic patients, group A had only a greater number of hospital days for cardiac disease (P = 0.050). Among patients without diabetes, group A had a higher number for hospital days for surgery or trauma (P = 0.027). All other univariate comparisons were not significant. Multiple linear regression identified comorbidity, quantified by the Charlson index, Caucasian race and poor compliance with the HD schedule as predictors of admission rate and days per year for vascular access issues and comorbidity, poor compliance, and advanced age at onset of HD as predictors of admission for causes other than vascular access related. CONCLUSION: Hospitalizations, which affect quality of life, differ little between elderly and younger patients on HD. Therefore, hospitalizations do not constitute an argument for restricting access to HD to elderly patients.

Death during hospitalization in patients on chronic hemodialysis.

Mortality from various causes is higher in patients on chronic hemodialysis (HD) than in the general population. There is evidence suggesting that some of the deaths in HD patients are preventable. To identify potentially preventable causes of death, we analyzed deaths that occurred in HD patients during hospitalization over a period of 15 years. We performed a retrospective cohort analysis of 410 patients on HD for at least 6 months between 1995 and 2009 (included), who had all their hospitalizations in the same hospital. The patients were classified into 3 groups: Those who died during hospitalization (group A, n=120), those who died away from the hospital (group B, n=135), and those who were alive at the end of the observation period (group C, n=155). Continuous variables were compared between groups by the Kruskall-Wallis statistic. Logistic regression was used to identify predictors of dying during the observation period and predictors of death in the hospital. For the whole HD group of 410 patients, only 9 (2.2%) were women. 59% of the patients had diabetes mellitus. Age at the onset of HD was 65.8 ± 11.5 years and the duration of HD was 34.4 ± 27.9 months. Group A patients had a higher annual rate and duration of hospitalization and a higher Charlson comorbidity index than either of the other 2 groups, and, in comparison with patients in group C, were older at the end of observation and had a shorter duration of HD. Cardiac disease (19.2%), vascular access complications (18.3%), peripheral vascular disease (16.7%), infections (15.8%), trauma (11.7%), central nervous system disease (7.5%), respiratory failure (4.2%), malignancy (3.3%), and gastrointestinal disease (3.3%) were the causes of the last hospitalization in group A. Compared with the patients who died during hospitalization without discontinuing HD, group A patients who discontinued HD had a longer duration of their last hospitalization (52.7 ± 77.7 vs. 14.3 ± 23.8 days, P<0.001). Discontinuation of HD occurred in 80% of the hospitalizations for respiratory failure, 75% of the hospitalizations for malignancy, 57% of the hospitalizations for trauma, and 56% of the hospitalizations for central nervous system disease. Logistic regression identified a high Charlson index, advanced age, and short duration of HD as predictors of death, and an absence of diabetes, high Charlson index, prolonged annual duration of hospitalization, and short distance of the patient's domicile from the dialysis unit as predictors of death in the hospital. A substantial number of hospitalizations leading to the death of HD patients are caused by potentially preventable conditions, including vascular access complications, peripheral vascular disease, and trauma. Implementation of measures preventing these hospitalizations is a worthwhile undertaking.

Eficacia de la tromboprofilaxis obstétrica / Efficacy of obstetrical tromboprophylaxis

Valorar la incidencia de enfermedad tromboembólica durante el embarazo, parto y puerperio en gestantes con riesgo y la efectividad de las tromboprofilaxis. Seguimiento de 2 727 gestantes con parto durante un año. Se realiza análisis descriptivo de nuestra población, de los factores de riesgo y de la duración de la tromboprofilaxis, analizando su relación con la incidencia de eventos tromboembólicos. Hospital Universitario San Cecilio de Granada, España. Nuestras gestantes tienen pocos factores de riesgo: cesárea, anemia posquirúrgica, tabaquismo, hipertensión inducida por el embarazo o previa, diabetes, cardiopatía y trombofilia, siendo la cesárea y la anemia los más frecuentes. La tromboprofilaxis postcesárea con nadroparina cálcica 0,4 diaria durante su hospitalización ha sido efectiva. No hubo ningún tromboembolismo. En nuestra población, con un adecuado control obstétrico y profilaxis con antiagregantes plaquetarios y/o heparinas de bajo peso molecular, se han evitado eventos tromboembólicos relacionados con el embarazo, parto puerperio.

Characterization and expression of the transcription factor PU.1 during LPS-induced inflammation in the rainbow trout (Oncorhynchus mykiss).

The transcription factor PU.1 plays a key role in hematopoietic lineage development and therefore in determining immune cell fate. A full length cDNA transcript of 1237 nucleotides encoding a highly conserved putative protein of 293 amino acids was identified by EST analysis in lipopolysaccharide (LPS) activated trout macrophages. Phylogenetic analyses highlight the significant level of structural conservation of the PU.1 transcription factor reinforcing the importance of this molecule in animal immunity. In trout, the PU.1 mRNA shows a tissue-specific expression pattern and is induced in vivo by LPS in muscle, liver, intestine and brain. Furthermore PU.1 is highly expressed in trout macrophages in primary culture. In situ expression analysis in the head kidney describes a large number of PU.1+ve cells distributed through the tissue in both LPS-treated and control animals. Cellular proliferation examined by BrdU immunohistochemistry (IHC) shows that LPS regulates hematopoietic processes in adult fish by stimulating cellular proliferation 3 days after treatment. These studies provide initial insights into hematopoietic/cellular processes in the head kidney of rainbow trout after in vivo LPS challenge.

Fractura subcapital de fémur secundaria a osteoporosis idiopática en el embarazo: a propósito de un caso / Subcapital fracture of the femur due to a idiopathic osteoporosis during pregnancy: a case report

Presentamos el caso de una paciente imposibilitada para la deambulación durante el puerperio, consecuencia de una fractura de fémur producida por una osteoporosis idiopática durante el embarazo. A los 11 meses del parto, la paciente presenta una evolución favorable con tratamiento médico con bifosfonatos y calcio.

We present the case of a mobility disabled person during puerperium as a consequence of a femur fracture due to an idiopathic osteoporosis during pregnancy. Eleven months after delivery, the patient's evolution was favourable with a medical treatment using bisphosphonates and calcium.

Estudio clínico epidemiológico de las neumonías en un hospital del Estado Carabobo, Venezuela, 1989-1993 / Study clinical epidemiology of the pneumonia in hospital the state Carabobo, Venezuela 1989-1993

Se presenta un estudio descriptivo de 129 pacientes cuyo diagnóstico de egreso fue neumonía epidémica infecciosa, seleccionado mediante la revisión de 147 historias clínicas de pacientes hospitalizados entre 1989 y 1993. Los resultados revelan una mayor incidencia (44,19 por ciento) durante enero, julio y agosto, con un promedio de estancia hospitalaria menor de 14 días en el 77,22 por ciento de los pacientes. El grupo de edad más afectado fue entre 21 y 47 años, y las complicaciones más frecuentes el abscenso pulmonar y el derrame pleural. El 50,63 por ciento de los pacientes entre 21 y 38 años presentan antecedentes de consumo combinado de sustancias lícitas e ilícitas, y el 69,23 por ciento de los menores de 21 años consume drogas ilícitas. Se identificó el agente etiológico en 13 de 129 pacientes, y 108 de ellos no fueron muestreados. Streptococcus pneumoniae fue el agente aislado con mayor frecuencia, y la penicilina, como monoterapia, fue utilizada en el 62,01 por ciento. Se concluye que el consumo de drogas lícitas e ilícitas, la falta de recursos institucionales y la ausencia de identificación de los agentes causales influye en la patogenia de la enfermedad y en las posibilidades de éxito terapéutico