RESUMO
In mice with Lewis lung carcinoma and melanoma B-16 administration of potentiated antibodies to tumor necrosis factor-alpha started 1 day after transplantation of a small number of tumor cells (10(6)) produced an antiblastic effect.
Assuntos
Anticorpos/uso terapêutico , Antineoplásicos/uso terapêutico , Fator de Necrose Tumoral alfa/imunologia , Animais , Anticorpos/imunologia , Carcinoma Pulmonar de Lewis/tratamento farmacológico , Melanoma/tratamento farmacológico , Camundongos , Camundongos Endogâmicos C57BLRESUMO
Single and course administration of ultralow doses of antibodies gamma-interferon did not increase the incidence of cytogenetic abnormalities in bone marrow cells from BALB/c mice and produced no genotoxic effect on Drosophila melanogaster wing cells in the test of somatic mosaicism.
Assuntos
Anticorpos/toxicidade , Células da Medula Óssea/efeitos dos fármacos , Drosophila melanogaster/efeitos dos fármacos , Interferon gama/imunologia , Mutagênicos/toxicidade , Animais , Anticorpos/imunologia , Células da Medula Óssea/citologia , Células Cultivadas , Relação Dose-Resposta a Droga , Camundongos , Camundongos Endogâmicos BALB C , Testes de Mutagenicidade , Asas de Animais/citologia , Asas de Animais/efeitos dos fármacosRESUMO
Morphological and morphometric assays showed that administration of antibodies to the prostate-specific antigen in ultralow doses for 1.5 months delayed the development of atrophic and sclerotic processes in rats with chronic aseptic prostatitis. The concentration of zinc ions playing an important role in binding of androgens increased in the prostate of rats receiving the preparation. Studies of copulatory behavior showed that male rats with chronic prostatitis receiving antibodies to the prostate-specific antigen displayed increased sexual activity compared to control and intact animals.
Assuntos
Anticorpos/farmacologia , Antígeno Prostático Específico/imunologia , Próstata/efeitos dos fármacos , Animais , Relação Dose-Resposta a Droga , Masculino , Próstata/patologia , Prostatite , Ratos , Comportamento Sexual Animal/efeitos dos fármacosRESUMO
Single and repeated administration of ultralow doses of antibodies to erythropoietin did not increase the count of aberrant metaphases in bone marrow cells of BALB/c mice and were not genotoxic for Drosophila melanogaster wing cells in the test of somatic mosaicism.