[Endometriosis]. / Endometriose.

Endometriosis Abstract. Endometriosis, which is the presence of functional endometrial tissue outside the endometrium, represents one of the most common gynecological diseases. Given the variability of the symptoms depending on the exact localization of the disease, it is not uncommon for a patient to be diagnosed only after approximately 10 years of suffering. Localizations of the disease can include the typical endometrioma of the ovaries and in particular the lesser pelvis (e. g., fallopian tubes, uterine ligaments). It is then termed "deep pelvic endometriosis" and may be the reason for scarring, chronic pelvic pain and infertility. MRI has become increasingly popular in assessing the extent of the disease, due to its increasing availability and excellent soft tissue contrast. Recently, European guidelines have been published to better standardize technical MRI parameters and reporting, in addition to several scoring systems (e. g., the ENZIAN score), which have been established in the past. This allows for a precise localization of the disease and may guide surgical management in advanced cases. Other therapeutic options - depending on the severity of the symptoms - include pain medication or hormonal treatments. In the case of adenomyosis, the embolization of the uterine arteries as a minimally invasive approach has demonstrated excellent results.

Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women.

Obesity and sarcopenia are major causes of morbidity and mortality among seniors. Vitamin D deficiency is very common especially among seniors and has been associated with both muscle health and obesity. This study investigated if 25-hydroxyvitamin D (25(OH)D) status is associated with body composition and insulin resistance using baseline data of a completed RCT among relatively healthy community-dwelling seniors (271 seniors age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis compared appendicular lean mass index (ALMI: lean mass kg/height m²) and fat mass index (FMI: fat mass kg/height m²) assessed by DXA and insulin resistance between quartiles of serum 25(OH)D concentration using multivariable linear regression adjusted for age, sex, smoking status, physical activity, and body mass index (BMI). Participants in the lowest serum 25(OH)D quartile (4.7⁻17.5 ng/mL) had a higher fat mass (9.3 kg/m²) compared with participants in the third (8.40 kg/m²; Q3 = 26.1⁻34.8 ng/mL) and highest (8.37 kg/m²; Q4 = 34.9⁻62.5 ng/mL) quartile (poverall = 0.03). Higher serum 25(OH)D quartile status was associated with higher insulin sensitivity (poverall = 0.03) and better beta cell function (p = 0.004). Prevalence of insulin resistance tended to be higher in the second compared with the highest serum 25(OH)D quartile (14.6% vs. 4.8%, p = 0.06). Our findings suggest that lower serum 25(OH)D status may be associated with greater fat mass and impaired glucose metabolism, independent of BMI and other risk factors for diabetes.