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Z Gastroenterol ; 53(4): 302-5, 2015 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-25860580

RESUMO

Langerhans cell histiocytosis is a disease with different clinical presentations and a wide spectrum of organ involvements. Rarely Langerhans cell histiocytosis can involve the gastrointestinal tract of adult patients. A case of infiltration of gastric mucosa by Langerhans cell histiocytosis is presented. The neoplastic nature of this infiltrate is underlined by the detection of a BRAF-V600E-mutation. Additionally, an overview of the so far 5 cases published in the English literature is provided. The published clinical experience indicates a benign curse of the disease.


Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Histiocitose de Células de Langerhans/genética , Polimorfismo de Nucleotídeo Único/genética , Proteínas Proto-Oncogênicas B-raf/genética , Gastropatias/diagnóstico , Gastropatias/genética , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Mutação/genética
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