RESUMO
ABSTRACT: Several vulvar lichen sclerosus (VLS) clinical severity scales have recently been proposed. In this prospective case series, we characterized histopathology in the context of clinical severity in 6 treatment-naïve postmenopausal patients with VLS. The Vulvar Quality of Life Index (VQLI) and an adaptation of the 2018 International Society for the Study of Vulvovaginal Disease Delphi consensus VLS severity score were administered. Vulvar skin punch biopsies were obtained to measure inflammatory density, constituent inflammatory cells, thickness of the stratum corneum and other epidermal layers, dermal edema, and dermal sclerosis. Clinicopathologic correlations were assessed. Two cases demonstrated sparse inflammatory densities, 1 case demonstrated patchy and nodular inflammatory density, 1 case demonstrated dense lichenoid inflammatory density, and 2 cases demonstrated dense lichenoid and epitheliotropic inflammatory densities. Those patients who reported severe pruritus demonstrated the greatest lymphocytic inflammatory densities on histopathological examination. Both cases of ulceration or erosion were associated with severe VQLI scores. Severe VQLI scores were also associated with trends for higher average thickness of the epidermal layers and of dermal sclerosis. Altogether, histopathologic grading of biopsy sites may reflect clinical severity in patients with VLS.
Assuntos
Líquen Escleroso e Atrófico , Líquen Escleroso Vulvar , Feminino , Humanos , Líquen Escleroso Vulvar/patologia , Qualidade de Vida , Esclerose/patologia , Vulva/patologia , Epiderme/patologia , Líquen Escleroso e Atrófico/patologiaAssuntos
Linfadenite Histiocítica Necrosante/diagnóstico , Linfo-Histiocitose Hemofagocítica/diagnóstico , Dermatopatias/patologia , Adulto , Anti-Inflamatórios/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Biópsia/métodos , Medula Óssea/patologia , Diagnóstico Diferencial , Quimioterapia Combinada , Exantema/diagnóstico , Exantema/etiologia , Feminino , Febre/diagnóstico , Febre/etiologia , Linfadenite Histiocítica Necrosante/tratamento farmacológico , Linfadenite Histiocítica Necrosante/patologia , Humanos , Linfadenopatia/diagnóstico , Linfadenopatia/etiologia , Linfo-Histiocitose Hemofagocítica/patologia , Prednisona/uso terapêutico , Resultado do TratamentoRESUMO
The prevalence of acute vulvovaginal involvement in toxic epidermal necrolysis can be as high as 70%; up to 28% of female patients will also develop chronic vulvovaginal sequelae. There is little consensus regarding prevention and treatment of the gynecologic sequelae of both Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). We review acute and chronic sequelae, including erosions, scar formation, chronic skin changes, urethral complications, adenosis, malignant transformation, vulvodynia, and dyspareunia. We provide comprehensive recommendations for acute and long-term vulvovaginal care in adult and pediatric SJS/TEN patients. Treatment should include an ultrapotent topical steroid, followed by a nonirritating barrier cream applied to vulvar and perineal lesions. A steroid should be used intravaginally along with vaginal dilation in all adults (but should be avoided in prepubertal adolescents) with vaginal involvement. Menstrual suppression should be considered in all reproductive age patients until vulvovaginal lesions have healed. Last, referrals for pelvic floor physical therapy and to surgical subspecialties should be offered on a case-by-case basis. This guide summarizes the current available literature combined with expert opinion of both dermatologists and gynecologists who treat a high volume of SJS/TEN patients.
Assuntos
Síndrome de Stevens-Johnson/complicações , Doenças Vaginais/etiologia , Doenças Vaginais/terapia , Doenças da Vulva/etiologia , Doenças da Vulva/terapia , Feminino , Humanos , Guias de Prática Clínica como Assunto , Síndrome de Stevens-Johnson/diagnóstico , Doenças Vaginais/prevenção & controle , Doenças da Vulva/prevenção & controleRESUMO
BACKGROUND: Plasma cell vulvitis (PCV) is an inflammatory vulvar dermatosis that is not well characterized. Diagnosis is often delayed, and the condition can be refractory to treatment. To date, there are no systematic reviews on this topic. OBJECTIVE: This study aimed to provide a systematic review of PCV, including epidemiologic, clinical, and histopathologic findings, as well as associated comorbidities and treatment options. METHODS: A primary literature search was conducted using the PubMed, Ovid Medline, Cochrane, and CINAHL databases. RESULTS: Fifty-three publications with 196 patients (mean age: 55.3 ± 14.5 years) were included. The majority of studies were case reports and case series. Common symptoms included burning/stinging (52%), dyspareunia (44%), and pruritus (41%). Common findings included erythema (84%), glistening/shiny appearance (29%), well-demarcated lesions (25%), and erosions (22%). Common anatomic sites were the labia minora (45%), introitus (31%), and periurethral (19%). Fifty-three percent of patients had a solitary lesion. Common histologic findings were a predominant plasma cell infiltrate (88%), presence of other inflammatory cells (55%), hemosiderin/siderophages (46%), and epidermal atrophy (43%). Topical corticosteroids (64%) and tacrolimus ointment (13%) were the most frequent treatment modalities. In most reports, previous treatments were tried, and there was a diagnostic delay. CONCLUSION: PCV is likely underrecognized and should be considered in patients with erythema of the mucous and modified mucous membranes, symptoms of burning or stinging, and a predominant plasma cell infiltrate on histopathology. First-line therapy should begin with high-potency topical corticosteroids, with the most evidence for clobetasol 0.05% or tacrolimus 0.1% ointment. Prospective studies are needed to further characterize this condition and to develop treatment guidelines.
Assuntos
Doença de Crohn/diagnóstico , Úlcera/etiologia , Doenças da Vulva/etiologia , Idoso , Clobetasol/uso terapêutico , Doença de Crohn/tratamento farmacológico , Fármacos Dermatológicos/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Infliximab/uso terapêutico , Hemissuccinato de Metilprednisolona/uso terapêutico , Úlcera/tratamento farmacológico , Úlcera/patologia , Doenças da Vulva/tratamento farmacológico , Doenças da Vulva/patologiaRESUMO
The most problematic vulvovaginal conditions are familiar to dermatologists but may exhibit distinct clinical features or medication management because of the anatomic location. The second article in this continuing medical education series focuses on management pearls for treating vulvar diseases. We highlight key conditions, such as lichen sclerosus, erosive lichen planus, and vulvodynia. In addition, we review conditions that dermatologists may be less familiar with, such as plasma cell vulvitis, desquamative inflammatory vaginitis, vulvar aphthae, and low estrogen states. Nearly 1 in 6 women experience undiagnosed and untreated vulvovaginal discomfort at some point in their lives. Physicians who treat vulvar disorders will improve the quality of life of countless women.
Assuntos
Dermatopatias/diagnóstico , Dermatopatias/terapia , Vagina/patologia , Doenças da Vulva/diagnóstico , Doenças da Vulva/terapia , Adulto , Atrofia/diagnóstico , Atrofia/terapia , Criança , Doença de Crohn/complicações , Feminino , Humanos , Líquen Plano/diagnóstico , Líquen Plano/terapia , Plasmócitos/patologia , Dermatopatias/etiologia , Úlcera Cutânea/diagnóstico , Úlcera Cutânea/tratamento farmacológico , Vaginite/diagnóstico , Vaginite/tratamento farmacológico , Doenças da Vulva/etiologia , Líquen Escleroso Vulvar/tratamento farmacológico , Vulvite/diagnóstico , Vulvite/tratamento farmacológico , Vulvodinia/diagnósticoAssuntos
Síndrome da Imunodeficiência Adquirida/complicações , Linfoma de Burkitt/complicações , Infecções por Citomegalovirus/diagnóstico , Herpes Simples/diagnóstico , Úlcera Cutânea/diagnóstico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biópsia , Ciclofosfamida/administração & dosagem , Citomegalovirus , Infecções por Citomegalovirus/complicações , Doxorrubicina/administração & dosagem , Etoposídeo/administração & dosagem , Herpes Simples/complicações , Humanos , Hospedeiro Imunocomprometido , Masculino , Rituximab/administração & dosagem , Simplexvirus , Úlcera Cutânea/complicaçõesRESUMO
We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angiocentric and dermal proliferation of markedly atypical lymphoid cells with numerous mitoses and apoptotic bodies along with broad zones of necrosis. Biopsy revealed the presentation to be consistent with NK/T-cell lymphoma. The cutaneous lesions from NK/T-cell lymphoma can often be initially mistaken for cellulitis, therefore this malignancy should be included on the differential in a patient HIV/acquired immune deficiency syndrome (AIDS).