Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies.

INTRODUCTION: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. METHODS: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. RESULTS: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). DISCUSSION: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Falling of older adults with cognitive impairment: a new home environment evaluation chart and a preliminary examination in the Wakuya Project / Queda de idosos com comprometimento cognitivo: uma nova ficha de avaliação do ambiente domiciliar e um exame preliminar no Projeto Wakuya

ABSTRACT. It is important to evaluate the home environment because most fractures in older adults are caused by falls indoors. However, previous studies have not separated individual abilities from environments. Also, the interrelationship between falls, cognitive function, and home environments has not been clarified. Objectives: The purpose of this study was to develop an evaluation method specific to the home environment and examine the effects of environment and cognitive impairment on falls. Methods: This was a case-control study analyzing 95 older adults living in the community. A Visiting Checklist for the Home Environment (VICHe) was developed and examined for reliability and validity. Inter-rater reliability (IRR) was examined by determining Cohen's kappa and the intra-class correlation coefficient. Guttman's split-half method was used for internal consistency, and Cronbach's alpha coefficient was obtained. Criterion-related validity was confirmed by Spearman's rank correlation coefficient with the Fall Risk Index's (FRI) total score of the environmental factor items. As a preliminary study, trends in the number of falls by cognitive function and home environment were examined. Results: The VICHe obtained validity, but the IRR was inadequate. In contrast, the version that focused on the on-floor environment (VICHe-OFI) showed IRR for all items and validity through correlations with the FRI. The number of fallers increased in the cognitive impairment group when the home environment was bad. Conclusions: Reliability and validity of the VICHe-OFI were obtained. Preliminary examination using this scale indicates that falls in the home of the elderly may be more affected by the home environment as cognitive function declines.

RESUMO. A avaliação do ambiente doméstico é importante pois a maioria das fraturas em idosos é causada por quedas dentro de casa. No entanto, estudos anteriores não separaram as habilidades individuais dos ambientes. Além disso, a inter-relação entre quedas, função cognitiva e ambientes domésticos não foi esclarecida. Objetivo: O objetivo foi desenvolver um método de avaliação específico para o ambiente doméstico e examinar os efeitos do ambiente e do comprometimento cognitivo nas quedas. Métodos: Este estudo foi um estudo de caso-controle analisando 95 idosos residentes na comunidade. Uma Lista de Verificação de Visitas para o Ambiente Doméstico (Visiting Checklist for Home Environment — VICHe) foi desenvolvida e examinada quanto à confiabilidade e validade. A confiabilidade entre avaliadores (CEA) foi examinada pela determinação do kappa de Cohen e do coeficiente de correlação intraclasse. O método split-half de Guttman foi usado para consistência interna e foi obtido o coeficiente alfa de Cronbach. A validade de critério foi confirmada pelo coeficiente de correlação de Spearman com a pontuação total da escala de risco de queda (ERQ) dos itens do fator ambiental. Como um estudo preliminar, foram examinadas as tendências no número de quedas por função cognitiva e ambiente doméstico. Resultados: O VICHe obteve validade, mas a CEA foi inadequada. Por outro lado, a versão que enfocou o ambiente "no chão" (VICHe-OFI) apresentou CEA para todos os itens e validade por meio de correlações com a ERQ. O número de quedas aumentou no grupo com comprometimento cognitivo quando o ambiente doméstico era ruim. Conclusões: Obteve-se confiabilidade e validade do VICHe-OFI. O exame preliminar com essa escala indica que as quedas do idoso no domicílio podem ser mais afetadas pelo ambiente doméstico à medida que a função cognitiva diminui.

Avoiding surgery in patients with dementia: is it the correct management? / Evitar cirurgia em pacientes com demência: é o manejo correto?

ABSTRACT. Although hospitalization for dementia is increasing, Japanese doctors often refrain from surgeries considering dementia. A woman in her 80s diagnosed with Alzheimer's disease was admitted to hospital for cholelithiasis. Due to the avoidance of surgery, the inflammation was prolonged and therefore she was unable to eat. Later, she was discharged with central venous nutrition. The care burden on family resulted in her readmission to another hospital. Eventually, the inflammation was alleviated, and she was able to eat. However, it took a long time. In this study, we not only emphasize the risks but also focus on the benefits to postoperative rehabilitation. We also discuss about the benefits of invasive procedures in patients with dementia.

RESUMO. Apesar do aumento de hospitalizações por demência, os médicos japoneses geralmente se abstêm de cirurgias ao considerar a demência. Uma mulher de 80 anos diagnosticada com doença de Alzheimer foi internada no hospital por colelitíase. O adiamento da cirurgia prolongou a inflamação e a deixou incapaz de comer. Ela foi forçada a receber alta com nutrição venosa central. A sobrecarga de cuidados para a família resultou em sua readmissão em outro hospital. Eventualmente, a inflamação foi aliviada e ela conseguiu comer. No entanto, levou muito tempo. Não devemos apenas enfatizar os riscos, mas também focar nos benefícios da reabilitação pós-operatória. Gostaríamos aqui de discutir e fornecer argumentos a favor de procedimentos invasivos em pacientes com demência.

Lower extremities task of pressing an "accelerator" or a "brake": association with traffic accidents in older drivers - a preliminary study / A tarefa das extremidades inferiores de pressionar um "acelerador" ou um "freio": associação com acidentes de trânsito em motoristas mais velhos - um estudo preliminar

ABSTRACT Traffic accidents by older drivers are a social urgent problem. The National Police Agency (NPA) in Japan has institutionalized the Cognitive Function Test (NPA test) for renewal of a driver's license for older adults. However, driving ability cannot be simply evaluated by usual cognitive tests on the desk. Objective: It is important to add an on-road test, but if not possible, we can use simulators. Before doing simulators, it is important to use the right foot to control the accelerator and brake pedals. We applied the Posner paradigm (visual attention test) for lower extremities. Methods: The participants were older adults. They and their families had anxiety about their driving. The 66 participants (44 men and 22 women) were divided into groups with and without experience of a traffic accident, and the following tests were examined: General cognitive and executive function tests, the NPA test, and an original Lower Extremity Reaction Test. Each participant was asked to press the "brake" or "accelerator" pedal by the right foot as quickly as possible in response to a traffic situation shown on the screen. Results: Compared to participants with favorable reactions to the Lower Extremity Reaction Test, those with poor reaction time tended to have more traffic accidents (OR=6.82), rather than the result of the NPA test. Conclusions: The results suggest that the probability of having a traffic accident can be better evaluated using the Lower Extremity Reaction Test.

RESUMO Os acidentes de trânsito por motoristas idosos são um problema social urgente. A Agência Nacional de Polícia (National Police Agency - NPA) no Japão institucionalizou o Teste de Função Cognitiva (teste NPA) para renovação de carteira de motorista para idosos. No entanto, a capacidade de dirigir não pode ser avaliada simplesmente por testes cognitivos usuais escritos. Objetivo: É importante adicionar um teste em estrada, mas se não for possível, simuladores podem ser utilizados. Antes de fazer simulações, é importante usar o pé direito para controlar os pedais do acelerador e do freio. Aplicamos o paradigma de Posner (teste de atenção visual) para extremidades inferiores. Métodos: Os participantes eram idosos. Eles e suas famílias tinham ansiedade sobre a condução de veículos. Os 66 participantes (44 homens e 22 mulheres) foram divididos em grupos com e sem experiência de acidente de trânsito, e foram examinados os seguintes testes: testes cognitivos gerais e funções executivas, o teste NPA, e um Teste de Reação de Extremidade Inferior original. Cada participante foi solicitado a pressionar o pedal de "freio" ou "acelerador" com o pé direito o mais rápido possível em resposta a uma situação de trânsito mostrada na tela. Resultados: Comparados aos participantes com reações favoráveis ao Teste de Reação de Extremidade Inferior, aqueles com tempo de reação ruim tenderam a ter mais acidentes de trânsito (OR=6,82) do que o resultado do teste NPA. Conclusões: s resultados sugerem que a probabilidade de ocorrência de um acidente de trânsito pode ser melhor avaliada por meio do Teste de Reação da Extremidade Inferior.

Monitoring of drug treatment and psychosocial intervention with SPECT in Alzheimer patients: implications for neurologically appropriate psychosocial interventions. An observational study. The Osaki-Tajiri Project / Monitoramento do tratamento medicamentoso e intervenção psicossocial com SPECT em pacientes com Alzheimer: implicações para intervenções psicossociais neurologicamente apropriadas. um estudo observacional. o Projeto Osaki-Tajiri

ABSTRACT We previously examined cerebral blood flow (CBF) with single-photon emission computed tomography (SPECT) in Alzheimer's disease (AD) with reference to drug treatment (donepezil) and psychosocial intervention. Objective: The aim is to provide "brain-based" evidence for psychosocial interventions using SPECT. Methods: The participants were 27 consecutive outpatients with AD who received the drug and psychosocial intervention, and SPECT three times (baseline, pre-/post-intervention) at 6 month-intervals. The significance level of changes in CBF (Z score) and the extent of significantly changed areas, calculated with the eZIS system, were used as monitoring parameters. The participants were classified into three groups: improve (post-intervention CBF increased), worsening (progressive decline), and no change. Results: Six, 8, and 13 patients were classified as improve, worsening, and no change, respectively. All subjects in the improve group showed improvement in cognitive test scores for the MMSE and/or the CGI scores associated with the brain area with a CBF increase (right parietal lobe), suggesting appropriate psychosocial intervention (visuospatial intervention). Conclusion: These results suggest that monitoring of CBF with the eZIS system may be clinically applicable for monitoring of drug treatment and psychosocial intervention in AD patients.

RESUMO Nós examinamos previamente o fluxo sanguíneo cerebral (FSC) com tomografia computadorizada de emissão de fóton único (SPECT) na doença de Alzheimer (DA) com referência ao tratamento medicamentoso (donepezila) e intervenção psicossocial. Objetivo: Fornecer evidências "baseadas no cérebro" para intervenções psicossociais usando o SPECT. Métodos: Os participantes foram 27 pacientes ambulatoriais consecutivos com DA que receberam a droga e intervenção psicossocial, e SPECT por três vezes (basal, pré/pós-intervenção) em intervalos de seis meses. O nível de significância das mudanças no FSC (escore Z) e a extensão das áreas significativamente alteradas calculadas com o sistema eZIS foram utilizados como parâmetros de monitoramento. Os participantes foram classificados em três grupos: melhora (FSC pós-intervenção aumentada), piora (declínio progressivo) e nenhuma mudança. Resultados: Seis, oito e 13 pacientes foram classificados como melhora, piora e sem alteração, respectivamente. Todos no grupo melhora mostraram aumento dos escores no MEEM e/ou nos escores do CGI associados à área do cérebro com aumento do FSC (lobo parietal direito), sugerindo intervenção psicossocial apropriada (intervenção visoespacial). Conclusão: Estes resultados sugerem que o monitoramento do FSC com o sistema eZIS pode ser clinicamente aplicável para o monitoramento do tratamento medicamentoso e intervenção psicossocial em pacientes com DA.

Impaired attention function based on the Montréal Cognitive Assessment in vascular dementia patients with frontal hypoperfusion: The Osaki-Tajiri project.

We previously reported that the Montréal Cognitive Assessment (MoCA) was effective in the evaluation of cerebrovascular diseases. We also demonstrated that the test was effective for screening for very mild vascular dementia (VaD) in the community. Herein, we examined the effectiveness of MoCA in the assessment of patients with VaD in an outpatient clinic. Forty-four patients with VaD (National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences [NINDS-AIREN] criteria) and 58 patients with Alzheimer's disease (AD) (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria) were compared with 67 non-demented control subjects. All were outpatients at the Tajiri Memory Clinic, Osaki-Tajiri, northern Japan. All underwent 1.5 Tesla MRI and ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) examinations. The SPECT images were used to classify the VaD patients into two subgroups, those with frontal hypoperfusion (F-VaD) and those without frontal hypoperfusion. The frontal hypoperfusion pattern was defined as the "P2" pattern of the Sliverman classification, with or without focal hypometabolism in other areas, based on the agreement of three neurologists who were blinded to the results of the neuropsychological examinations. Total scores and attention subscores on the MoCA were lower in the F-VaD group compared with other groups. Our results suggest that the MoCA attention subscale can detect VaD participants, particularly those with frontal hypoperfusion.

A potential protective effect in multilingual patients with semantic dementia: two case reports of patients speaking Taiwanese and Japanese.

PURPOSE: Several reports have suggested that multilingualism has a protective effect against semantic dementia. Here, we provide further evidence for this effect. CASE REPORTS FIRST: The patient was a 75-year-old right-handed Taiwanese woman who had retired after working as a tailor. She was able to speak Taiwanese, Japanese and Mandarin Chinese fluently until 5 years ago. She gradually developed symptoms of profound anomia and difficulty with word-finding. Her mother tongue was Taiwanese and she had learned Japanese as her first symbolized language. She had used Mandarin Chinese for most of her life, but depended on Japanese to read and write (such as reading a newspaper and keeping accounts). However, she could now speak only very simple Taiwanese and Japanese, and could recognize only simple Japanese characters. SECOND: The patient was a 62-year-old right-handed man who had worked as an ironworker. He could speak Taiwanese and Mandarin Chinese fluently until 5 years ago. His mother tongue was Taiwanese. After 5 years of language deterioration, he was unable to communicate with his family members or recognize any characters, including numbers. SPECT RESULTS: Brain perfusion ECD SPECT (Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography) showed less perfusion in the multilingual patient (Case #1) than in the bilingual patient (Case #2). Neuropsychological tests also demonstrated a slower rate of degeneration in the multilingual patient. CONCLUSION: We speculate that reading and writing in Japanese had a greater impact on the semantic system in Case #1. Thus, this patient showed relatively less degeneration or functional inactivity, as shown by perfusion in the frontal lobe, and this might be due to the persistent activation involved in multilingualism.

Agrafia para Kanji e Kana em comprometimento cognitivo leve e demência: comparação transcultural de indivíduos idosos morando no Japão e Brasil / Kanji and Kana agraphia in mild cognitive impairment and dementia: a trans-cultural comparison of elderly Japanesesubjects living in Japan and Brazil

This study verifies the environmental effects on agraphia in mild cognitive impairment and dementia. We compared elderly Japanese subjects living in Japan and Brazil. Methods: We retrospectively analyzed the database of the Prevalence Study 1998 in Tajiri (n=497, Miyagi, Japan) and the Prevalence Study 1997 of elderly Japanese immigrants living in Brazil (n=166, migrated from Japan and living in the São Paulo Metropolitan Area). In three Clinical Dementia Rating (CDR) groups, i.e., CDR 0 (healthy), CDR 0.5 (questionable dementia), and CDR 1+ (dementia) , the Mini-Mental State Examination (MMSE) item of spontaneous writing and the Cognitive Abilities Screening Instrument (CASI) domain of dictation were analyzed with regard to the number of Kanji and Kana characters. Formal errors in characters and pragmatic errors were also analyzed. Results: The immigrants in Brazil wrote similar numbers of Kanji or Kana characters compared to the residents of Japan. In spontaneous writing, the formal Kanji errors were greater in the CDR 1+ group of immigrants. In writing from dictation, all the immigrant CDR groups made more formal errors in Kana than the Japan residents. No significant differences in pragmatic errors were detected between the two groups. Conclusions: Subjects living in Japan use Kanji frequently, and thus the form of written characters was simplified, which might be assessed as mild formal errors. In immigrants, the deterioration in Kanji and Kana writing was partly due to decreased daily usage of the characters. Lower levels of education of immigrants might also be related to the number of Kanji errors.

Este estudo verifica os efeitos do meio ambiente sobre a agrafia em comprometimento cognitivo leve e demência. Nós comparamos indivíduos idosos vivendo no Japão e Brasil. Métodos: Nós, retrospectivamente, analisamos a base de dados do Estudo de Prevalência 1998 em Tajiri (n=497, Miyagi, Japão) e do Estudo de Prevalência 1997 de imigrantes idosos japoneses vivendo no Brasil (n=166, imigrados do Japão e residindo na área metropolitana da cidade de São Paulo). Em três grupos de CDR (Clinical Dementia Rating), isto é, CDR 0 (saudáveis), CDR 0.5 (demência questionável) e CDR1+ (demência), o item de escrita espontânea do Mini-Exame do Estado Mental (MEEM) e o domínio de ditado do Cognitive Abilities Screening Instrument (CASI) foram analisados em relação ao número de caracteres em Kanji e Kana. Erros formais nos caracteres e erros pragmáticos foram também analisados. Resultados: Os imigrantes no Brasil escreveram número similar de caracteres de Kanji e Kana comparados aos residentes no Japão. Na escrita espontânea, os erros formais de Kanji foram maiores no grupo de CDR1+ em imigrantes. Na escrita sob ditado, todos os grupos de CDR de imigrantes fizeram mais erros formais em Kana do que os residentes no Japão. Nenhuma diferença foi encontrada em erros pragmáticos entre os grupos. Conclusões: Sujeitos vivendo no Japão usam Kanji freqüentemente, e então, a forma de caracteres escritos foi simplificada, o que pode ser avaliado como discretos erros formais. Em imigrantes, a deterioração na escrita em Kanji e Kana foi parcialmente devida ao uso diário restrito dos caracteres. Baixos níveis educacionais dos imigrantes podem estar relacionados ao número de erros em Kanji.

Collage technique may provide new perspectives for Alzheimer patients by exploring messages from their inner world / Técnica de colagem pode dar novas perspectivas para pacientes com doença de Alzheimer através da exploração do seu mundo interior

Abstract: Although the collage art technique has been introduced as a psychotherapeutic method, it has not been fully applied in dementia. Objectives: To analyze characteristics of the collage articles produced by patients with Alzheimer's disease (AD). Methods: Twenty AD patients were asked to select and place several clippings as they wished. The MMSE was used for cognitive assessments. Results: Simplification and poor organization in their articles were found. The themes of one patient were found to change according to behavior. We discussed the images of the articles, especially spiritual images in the early stage and family images in the later stage. Conclusions: We concluded that the collage technique could provide new perspectives for dementia patients by exploring messages from their inner world.

Resumo: Embora a técnica de colagem tenha sido introduzida como um método psicoterapêutico, ela não foi totalmente aplicada em demência. Objetivos: Analisar as características de trabalhos de colagens feitos por pacientes com doença de Alzheimer (DA). Métodos: A 20 pacientes foi solicitado que selecionassem e colocassem peças que apreciassem. O MEEM foi utilizado para avaliação cognitiva. Resultados: Simplificação e organização pobres foram encontradas. Nós demonstramos um paciente cujos temas foram mudando em relação ao comportamento. Nós discutimos as imagens dos artigos, especialmente imagens espirituais no estágio precoce e imagens familiares no estágio tardio. Conclusões: Nós consideramos que a técnica de colagem poderia dar novas perspectivas na demência, explorando a mensagem do mundo interior.

Cross-cultural comparisons of the Mini-mental State Examination between Japanese and U.S. cohorts.

BACKGROUND: The Mini-mental State Examination (MMSE) is widely used in Japan and the U.S.A. for cognitive screening in the clinical setting and in epidemiological studies. A previous Japanese community study reported distributions of the MMSE total score very similar to that of the U.S.A. METHODS: Data were obtained from the Monongahela Valley Independent Elder's Study (MoVIES), a representative sample of community-dwelling elderly people aged 65 and older living near Pittsburgh, U.S.A., and from the Tajiri Project, with similar aims in Tajiri, Japan. We examined item-by-item distributions of the MMSE between two cohorts, comparing (1) percentage of correct answers for each item within each cohort, and (2) relative difficulty of each item measured by Item Characteristic Curve analysis (ICC), which estimates log odds of obtaining a correct answer adjusted for the remaining MMSE items, demographic variables (age, gender, education) and interactions of demographic variables and cohort. RESULTS: Median MMSE scores were very similar between the two samples within the same education groups. However, the relative difficulty of each item differed substantially between the two cohorts. Specifically, recall and auditory comprehension were easier for the Tajiri group, but reading comprehension and sentence construction were easier for the MoVIES group. CONCLUSIONS: Our results reaffirm the importance of validation and examination of thresholds in each cohort to be studied when a common instrument is used as a dementia screening tool or for defining cognitive impairment.

Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri Project.

The incidence of dementia and risk factors has not been fully investigated in Japan. Following a prevalence study in 1998, we investigated the incidence and associated factors in the same population in 2003 and 2005. Randomly selected 771 residents in Tajiri were targeted. The final participants included 204 (65.2%) healthy older adults (Clinical Dementia Rating, CDR 0) and 335 (73.1%) people with questionable dementia (CDR 0.5). We analyzed the incidence of dementia and dementing diseases, and possible risk factors. The risk factors included demographics, lifestyle-related factors, vascular risk factors, cognitive functions, and MRI findings. Overall, 3.9% of the CDR 0 and 37.0% of the CDR 0.5 participants developed dementia during the 5-year period, whereas 40.2% of the CDR 0.5 participants developed dementia during the 7-year period. Older adults had a higher incidence. Higher CDR Box scores had a higher incidence. Of the dementing diseases, 60.8% of participants developed Alzheimer' disease (AD), followed by vascular dementia (VaD), 17.9%. Logistic regression analyses showed that age, MMSE, cognitive functions such as recent memory, and generalized atrophy were significant predictors of progression to AD. Similarly, predictive factors for progression to VaD were age, MMSE, cognitive functions such as frontal function, and white matter lesions and cerebrovascular diseases. A comprehensive system including CDR, cognitive tests, and MRI, is recommended in community-based health policy planning.