Do differences exist between chronic hepatitis C genotypes 2 and 3?

Introduction Six genotypes of the hepatitis C virus (HCV) have been identified thus far, and their distribution is well defined. Genotype 1, which is the most prevalent worldwide, is always compared to genotypes 2 and 3, particularly in terms of treatment response. However, little is known about the differences between genotypes 2 and 3 because these genotypes are analyzed together in most studies. Therefore, the aim of this study was to evaluate differences in the clinical, epidemiological, laboratory, and histological parameters between HCV-2 and HCV-3. Methods Patients with chronic hepatitis C infected with genotypes 2 and 3 were studied retrospectively and compared according to clinical, laboratory, and histological aspects. Hepatitis C virus-ribonucleic acid (HCV-RNA) was analyzed quantitatively by TaqMan® real-time PCR, and the HCV genotype was determined by sequencing the 5′-untranslated region. Results A total of 306 patients with chronic HCV-2 (n=50) and HCV-3 (n = 256) were studied. Subtype 2b (n=17/50) and subtype 3a (n=244/256) were the most prevalent among patients infected with HCV-2 and HCV-3, respectively. The mean age was 47 ± 10 years, and there was a predominance of men in the group studied (61%). Comparative analysis between HCV-2 and HCV-3 showed a younger age (p=0.002), less prevalence of arterial hypertension (p=0.03), higher serum albumin levels (p=0.01), more advanced stage of liver fibrosis (p=0.03), and higher frequency of steatosis in patients with HCV-3 (p=0.001). After multivariate regression analysis, all the variables, except serum albumin, remained as variables associated with HCV-3 in the final model. Conclusions Clinical and histological differences exist between HCV-2 and HVC-3, which suggests the need for separate analyses of these genotypes. .

Doença de Rosai-Dorfman

A doença de Rosai-Dorfman ou Histiocitose Sinusal com Linfadenomegalia Maciça é uma desorganização histiocitária proliferativa rara. Tem como principal manifestação clínica Linfonodomegalia cervical, mas pode atingir outros linfonodos e órgãos extranodais. A etiologia ainda não é bem conhecida, porém há estudos associando com patógenos infecciosos e imunodeficiência...The Rosai-Dorfman or Sinus Histiocytosis with Massive adenomegaly clutter is a rare histiocytic proliferative. Its main clinical manifestation of cervical Lymph node enlargement, but may spread to other lymph nodes and extranodal organs. The etiology is not well known, but there are reports of associated with infectious pathogens and immunodeficiency ...