Assuntos
Encéfalo/patologia , Síndrome Hipereosinofílica/diagnóstico , Imageamento por Ressonância Magnética , Mielinólise Central da Ponte/diagnóstico , Idoso , Linfócitos T CD8-Positivos/patologia , Humanos , Masculino , Fibras Nervosas Mielinizadas/patologia , Exame Neurológico , Nervos Periféricos/patologiaRESUMO
We describe the case of a human immunodeficiency virus-infected 34-year-old man with progressive multifocal leukoencephalopathy (PML). His case displayed unusual features, including a bizarre movement disorder, predominant involvement of the subcortical U fibers on neuropathologic examination, and the absence of MRI abnormalities suggestive of PML. Anatomic-clinical correlations are discussed.
Assuntos
Complexo AIDS Demência/patologia , Complexo AIDS Demência/fisiopatologia , Síndrome da Imunodeficiência Adquirida/fisiopatologia , Encéfalo/patologia , Transtornos dos Movimentos/fisiopatologia , Síndrome da Imunodeficiência Adquirida/patologia , Adulto , Encéfalo/virologia , Evolução Fatal , Humanos , Hibridização In Situ , Vírus JC/isolamento & purificação , Imageamento por Ressonância Magnética , Masculino , Transtornos dos Movimentos/patologia , Valores de ReferênciaRESUMO
A 64-year-old woman was repeatedly hospitalized for various recurrent clinical signs of central nervous system involvement. The diagnosis of primary Sjögren's syndrome was established 3 years 6 months after the onset of the disease. Sicca symptoms, as well as inflammatory biological abnormalities were absent. Moreover, both lacrymal and salivary gland secretions were affected. A high level of antinuclear antibodies to SSA and SSB was associated with inflammatory lesions in minor salivary glands biopsy samples consistent with the diagnosis of Sjögren's syndrome.
Assuntos
Doenças do Sistema Nervoso Central/etiologia , Síndrome de Sjogren/complicações , Anticorpos Antinucleares/análise , Doenças do Sistema Nervoso Central/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , RecidivaAssuntos
Neoplasias Encefálicas/imunologia , Linfócitos T CD4-Positivos/imunologia , Glioblastoma/imunologia , Síndromes de Imunodeficiência/imunologia , Antígenos Comuns de Leucócito/imunologia , Subpopulações de Linfócitos T/imunologia , Adulto , Antígenos CD/imunologia , Relação CD4-CD8 , Feminino , Humanos , Integrina beta1 , Contagem de Leucócitos , Masculino , Pessoa de Meia-IdadeRESUMO
A new technique for the quantitation of isoenzymes was applied to assess the proportions of red cells in the circulation of parabiosed mice. Two parent-F1 hybrid combinations showing phosphoglucose isomerase polymorphism were examined at successive stages of parabiosis and after separation. Once red cell populations became mixed, 3 days after union, the ratio of red cell phenotypes was never significantly different from one partner to the other, although parental red cells became predominant after about 20 days. However, F1 hybrid red cells could always be detected. After separation of parabiosed mice there was a return to the original composition although this took longer than would be expected on the basis of reported red cell life span. Packed cell volume measurements indicated that a parental polycythaemia and F1 hybrid anaemia developed in one strain combination but not in the other. Evidence was adduced to support the hypothesis of a difference in red cell flux being responsible for the generation of this polycythaemia-anaemia.