RESUMO
Objective.Four-dimensional cone-beam computed tomography (4D CBCT) has unique advantages in moving target localization, tracking and therapeutic dose accumulation in adaptive radiotherapy. However, the severe fringe artifacts and noise degradation caused by 4D CBCT reconstruction restrict its clinical application. We propose a novel deep unsupervised learning model to generate the high-quality 4D CBCT from the poor-quality 4D CBCT.Approach.The proposed model uses a contrastive loss function to preserve the anatomical structure in the corrected image. To preserve the relationship between the input and output image, we use a multilayer, patch-based method rather than operate on entire images. Furthermore, we draw negatives from within the input 4D CBCT rather than from the rest of the dataset.Main results.The results showed that the streak and motion artifacts were significantly suppressed. The spatial resolution of the pulmonary vessels and microstructure were also improved. To demonstrate the results in the different directions, we make the animation to show the different views of the predicted correction image in the supplementary animation.Significance.The proposed method can be integrated into any 4D CBCT reconstruction method and maybe a practical way to enhance the image quality of the 4D CBCT.