Assuntos
Adenocarcinoma/complicações , Ictiose/etiologia , Síndromes Paraneoplásicas/etiologia , Neoplasias Gástricas/complicações , Adenocarcinoma/secundário , Evolução Fatal , Humanos , Ictiose/patologia , Masculino , Pessoa de Meia-Idade , Síndromes Paraneoplásicas/patologia , Neoplasias Gástricas/patologiaRESUMO
Mycetoma is a chronic granulomatous disease, classified into eumycetoma caused by fungi and actinomycetoma due to aerobic filamentous actinomycetes. Mycetoma can be found in geographic areas near the Tropic of Cancer. Mexico is one of the countries in which actinomycetoma is endemic. We report an extraordinary case of an adult male with double eumycetoma caused by Madurella mycetomatis and Fusarium verticillioides on both feet.
Assuntos
Dermatoses do Pé/microbiologia , Fusarium/isolamento & purificação , Madurella/isolamento & purificação , Micetoma/microbiologia , Dermatoses do Pé/diagnóstico , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Post-burn hypertrophic scars are characterized by increased collagen synthesis and hyperplasia, and may be associated with erythema, pain, dysesthesia, pruritus, and skin border elevation. Although the etiopathogenesis of hypertrophic scarring remains unclear, proinflammatory and profibrogenic cytokines are known to play an important role in general skin dysfunction. This study assessed mRNA expression, proteins, and type I receptors of tumor necrosis factor-alpha (TNF-α) and interleukin 1-beta (IL-1ß) in normal skin, normotrophic and post-burn hypertrophic scars. Skin biopsies were obtained from 10 hypertrophic and 9 normotrophic scars, and 4 normal skin sites. Only post-burn scars covering more than 10% of the body were included. Ex vivo histopathological analysis evaluated scar maturity, in situ hybridization assessed mRNA expression, and cytokine protein and cytokine/cell colocalization were performed using single- and double-label immunohistochemistry, respectively. IL-1ß is overexpressed in hypertrophic scars at the post-transcriptional level, associated primarily with keratinocytes and CD1a(+) cells. Type I receptors for TNF-α are overexpressed in blood vessels of hypertrophic scars. The coordinated overexpression of IL-1ß and TNF-α type I receptor may maintain the fibrogenic phenotypes of hypertrophic scars, even those in "remission".
Assuntos
Queimaduras/complicações , Cicatriz Hipertrófica/metabolismo , Interleucina-1beta/metabolismo , RNA Mensageiro/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo , Análise de Variância , Cicatriz Hipertrófica/etiologia , Humanos , Imuno-Histoquímica , Hibridização In Situ , Interleucina-1beta/genéticaRESUMO
A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012 microg/ml.
Assuntos
Antifúngicos/uso terapêutico , Ascomicetos/isolamento & purificação , Dermatoses do Pé , Itraconazol/uso terapêutico , Micetoma , Ascomicetos/classificação , Ascomicetos/efeitos dos fármacos , Ascomicetos/genética , Dermatoses do Pé/tratamento farmacológico , Dermatoses do Pé/microbiologia , Dermatoses do Pé/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Micetoma/tratamento farmacológico , Micetoma/microbiologia , Micetoma/patologia , Resultado do TratamentoRESUMO
Dermal dendrocyte hamartomas are extremely rare; only two examples have been described with clinical features different from our cases and with incomplete immunohistochemical characterization. We report three female patients presenting a medallion-shaped, well-defined, slightly atrophic and asymptomatic congenital lesion. All 3 patients showed a fusiform-cell proliferation. Immunohistochemistry was positive for CD34, factor XIIIa, and fascin. Electron microscopy showed typical features of dermal dendrocytes. We believe that the lesions described represent a new, clinically and histopathologically distinct lesion originating in dermal dendrocytes. We propose to name it medallion-like dermal dendrocyte hamartoma.
Assuntos
Hamartoma/patologia , Dermatopatias/patologia , Antígenos CD34/análise , Proteínas de Transporte/análise , Criança , Diagnóstico Diferencial , Fator XIIIa/análise , Feminino , Hamartoma/classificação , Hamartoma/congênito , Hamartoma/metabolismo , Humanos , Proteínas dos Microfilamentos/análise , Microscopia Eletrônica , Neurofibroma/diagnóstico , Dermatopatias/classificação , Dermatopatias/congênito , Dermatopatias/metabolismo , Vimentina/análiseRESUMO
Estudio clínico-patológico, comparativo y retrospectivo en 260 pacientes con lipomas y angiolipomas, en un periodo de 18 años. El 52.6 por ciento de los casos correspondieron a lipomas y el 47.3 por ciento a angiolipomas. A diferencia de los lipomas, los angiolipomas mostraron una mayor tendencia a presentarse como tumores múltiples y dolorosos, ocurriendo en individuos relativamente más jovenes