Assuntos
Cianose/etiologia , Neoplasias Ovarianas/diagnóstico , Teratoma/diagnóstico , Adulto , Aglutininas/sangue , Crioglobulinas , Cianose/sangue , Diagnóstico Diferencial , Feminino , Hemaglutininas/sangue , Humanos , Neoplasias Ovarianas/sangue , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/cirurgia , Teratoma/sangue , Teratoma/complicações , Teratoma/cirurgiaRESUMO
Platelet alpha-granule release in 22 patients affected by chronic myeloproliferative disorders with thrombocytosis and seven subjects with thrombocytosis secondary to splenectomy were studied. We found elevated beta-thromboglobulin (BTG) and platelet factor 4 (PF4) plasma levels in all patients. Intraplatelet content of BTG and PF4 was decreased in patients with idiopathic thrombocythaemia (IT) and idiopathic myelofibrosis (IMF). The BTG and PF4 results were also expressed as the ratio plasma BTG and PF4: whole blood platelet count. In patients with IT, BTG: whole blood platelet count ratio was low, conversely, the same ratio was high in patients with IMF. In conclusion, our results suggest the presence of an abnormal, BTG-deficient clone in IT and a peripheral platelet activation in IMF.
Assuntos
beta-Globulinas/metabolismo , Plaquetas/metabolismo , Transtornos Mieloproliferativos/sangue , Fator Plaquetário 4/metabolismo , Trombocitose/sangue , beta-Tromboglobulina/metabolismo , Doença Crônica , Humanos , Contagem de PlaquetasRESUMO
A case of pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy) is presented. This chronic and usually self-limited condition must be differentiated from other diseases, such as acromegaly, the osteoarthropaties complicating disorders of the connective tissue and osteoarthropaties in paraneoplastic syndromes.