RESUMO
BACKGROUND: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. METHODS: We studied 49â334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25â
years, and overall, 5-25â
years). The obstructive phenotype was defined as forced expiratory volume in 1â
s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score