RESUMO
Pericallosal arteriovenous malformations are rarely reported, particularly in children. Moreover, few arteriovenous malformation studies report thorough neuropsychological outcome data for assessing post-surgical functioning. This case report provides a longitudinal study of a boy who initially presented for neuropsychological testing at the age of 8 years and 1 month, following polyvinyl alcohol embolization, two craniotomies and resections and stereotactic radiosurgery for a pericallosal arteriovenous malformation involving nearly all of the corpus callosum. Follow-up magnetic resonance imaging also indicated absence of the left fornix. Functioning has been assessed over 7 years. Neuropsychological measures identified a consistent pattern of verbally mediated cognitive and memory deficits, with relatively spared visual perceptual and visual motor functioning. No evidence of a split-brain syndrome was found. The findings are consistent with insult to dominant hemisphere language and memory systems, provide an interesting example of neurodevelopmental compensation for significant early brain insult, and may provide insight into functions subserved by the fornix.
Assuntos
Dano Encefálico Crônico/diagnóstico , Corpo Caloso/irrigação sanguínea , Malformações Arteriovenosas Intracranianas/cirurgia , Testes Neuropsicológicos , Complicações Pós-Operatórias/diagnóstico , Dano Encefálico Crônico/fisiopatologia , Dano Encefálico Crônico/psicologia , Criança , Corpo Caloso/fisiopatologia , Corpo Caloso/cirurgia , Dominância Cerebral/fisiologia , Seguimentos , Fórnice/fisiopatologia , Humanos , Masculino , Rememoração Mental/fisiologia , Plasticidade Neuronal/fisiologia , Complicações Pós-Operatórias/fisiopatologia , Complicações Pós-Operatórias/psicologia , Desempenho Psicomotor/fisiologia , Reoperação , Aprendizagem Verbal/fisiologiaRESUMO
PURPOSE: To report initial clinical experience with a novel high-precision stereotactic radiotherapy system. METHODS AND MATERIALS: Sixty patients ranging in age from 2 to 82 years received a total of 1426 treatments with the University of Florida frameless stereotactic radiotherapy system. Of the total, 39 (65%) were treated with stereotactic radiotherapy (SRT) alone, and 21 (35%) received SRT as a component of radiotherapy. Pathologic diagnoses included meningiomas (15 patients), low-grade astrocytomas (11 patients), germinomas (9 patients), and craniopharyngiomas (5 patients). The technique was used as means of dose escalation in 11 patients (18%) with aggressive tumors. Treatment reproducibility was measured by comparing bite plate positioning registered by infrared light-emitting diodes (IRLEDs) with the stereotactic radiosurgery reference system, and with measurements from each treatment arc for the 1426 daily treatments (5808 positions). We chose 0.3 mm vector translation error and 0.3 degrees rotation about each axis as the maximum tolerated misalignment before treating each arc. RESULTS: With a mean follow-up of 11 months, 3 patients had recurrence of malignant disease. Acute side effects were minimal. Of 11 patients with low grade astrocytomas, 4 (36%) had cerebral edema and increased enhancement on MR scans in the first year, and 2 required steroids. All had resolution and marked tumor involution on follow-up imaging. Bite plate reproducibility was as follows. Translational errors: anterior-posterior, 0.01 +/- 0.10; lateral, 0.02 +/- 0.07; axial, 0.01 +/- 0.10. Rotational errors (degrees): anterior-posterior, 0.00 +/- 0.03; lateral, 0.00 +/- 0.06; axial, 0.01 +/- 0.04. No patient treatment was delivered beyond the maximum tolerated misalignment. Daily treatment was delivered in approximately 15 min per patient. CONCLUSION: Our initial experience with stereotactic radiotherapy using the infrared camera guidance system was good. Patient selection and treatment strategies are evolving rapidly. Treatment accuracy was the best reported, and the treatment approach was practical.
Assuntos
Neoplasias Encefálicas/cirurgia , Neoplasias Meníngeas/cirurgia , Neoplasias Hipofisárias/cirurgia , Radiocirurgia/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Astrocitoma/cirurgia , Criança , Pré-Escolar , Craniofaringioma/cirurgia , Fracionamento da Dose de Radiação , Feminino , Germinoma/cirurgia , Humanos , Masculino , Meningioma/cirurgia , Pessoa de Meia-Idade , Radioterapia Assistida por ComputadorRESUMO
PURPOSE: Time-dose relationships have proven important in many cancer sites. This study evaluates the time factors involved in the successful postoperative radiotherapy of medulloblastoma, based on a 30-year experience in a single institution. METHODS AND MATERIALS: Fifty-three patients with medulloblastoma received postoperative craniospinal radiotherapy with curative intent between 1963 and 1993. Seven patients (13%) underwent biopsy alone, 28 patients (53%) had subtotal excision, and 18 patients (34%) had gross total excision. Eleven patients received adjuvant chemotherapy. The mean posterior fossa dose was 53.1 Gy; most patients received 54.0 Gy (range, 34.3 to 69.6 Gy). For 41 patients receiving once-a-day therapy, the mean dose was 50.6 Gy (range, 34.3 to 56.0 Gy). For 12 patients receiving twice-a-day therapy, the mean dose was 61.8 Gy (range, 52.6 to 69.6 Gy). Minimum follow-up was 2 years, and median follow-up was 10.7 years. Survival, freedom from relapse, and disease control in the posterior fossa were calculated using the Kaplan-Meier method, and multivariate analysis was performed for prognostic factors. Variables related to radiotherapy were examined, including dose to the craniospinal axis, dose to the posterior fossa, fractionation (once-a-day vs. twice-a-day), use of adjuvant chemotherapy, risk group [high (> or =T3b or > or =M1) or low (< or =T3a and M0-MX)], interval between surgery and radiotherapy (excluding patients receiving chemotherapy before radiotherapy), and duration of radiotherapy. RESULTS: At 5 and 10 years, overall survival rates were 68 and 64%, respectively, and freedom-from-relapse rates were 61 and 52%, respectively. Rates of disease control in the posterior fossa at 5 and 10 years were 79 and 68%, respectively. At 5 years, absolute survival rates after biopsy alone, subtotal excision, and gross total excision were 43, 67, and 78%, respectively (p=0.04), and posterior fossa control rates were 27, 89, and 83%, respectively (p=0.004). Duration of the treatment course was the only radiotherapy-related variable with a significant impact on freedom from relapse and posterior fossa control. For patients whose radiation treatment duration was < or =45 days, posterior fossa control was 89% at 5 years, compared with 68% for those treated for >45 days (p=0.01). Duration of treatment also affected freedom from relapse at 5 years: < or =45 days (76%) compared with >45 days (43%), p=0.004. CONCLUSION: Our study demonstrates that if adequate doses are used, then radiotherapy treatment duration will significantly affect the outcome in terms of control of disease in the posterior fossa and freedom from relapse. Fractions of at least 1.75 Gy given once a day, or a twice-a-day regimen should yield optimal local control results.
Assuntos
Neoplasias Cerebelares/radioterapia , Irradiação Craniana , Meduloblastoma/radioterapia , Adolescente , Adulto , Idoso , Análise de Variância , Neoplasias Cerebelares/cirurgia , Criança , Pré-Escolar , Terapia Combinada , Fossa Craniana Posterior , Intervalo Livre de Doença , Relação Dose-Resposta à Radiação , Feminino , Seguimentos , Humanos , Masculino , Meduloblastoma/cirurgia , Pessoa de Meia-Idade , Fatores de TempoRESUMO
Retrorectal cyst-hamartoma, an uncommon lesion, arises from hindgut embryonic remnants and may be associated with sacral anomalies. Such a lesion is presacral, multicystic, and lined with glandular or transitional epithelium. Malignant transformation of these lesions has been reported. We describe the clinical, pathologic, and imaging findings in an infant.
Assuntos
Cistos/congênito , Imageamento por Ressonância Magnética , Defeitos do Tubo Neural/diagnóstico , Doenças Retais/congênito , Sacro/anormalidades , Espinha Bífida Oculta/diagnóstico , Cistos/diagnóstico , Cistos/patologia , Epitélio/patologia , Humanos , Lactente , Masculino , Defeitos do Tubo Neural/patologia , Doenças Retais/diagnóstico , Doenças Retais/patologia , Reto/patologia , Sacro/patologia , Espinha Bífida Oculta/patologiaRESUMO
PURPOSE: To review the University of Florida experience in treating ependymomas, analyze prognostic factors, and provide treatment recommendations. METHODS AND MATERIALS: Forty-one patients with ependymoma and no metastases outside the central nervous system received postoperative radiotherapy with curative intent between 1966 and 1989. Ten patients had supratentorial lesions, 22 had infratentorial lesions, and 9 had spinal cord lesions. All patients had surgery (stereotactic biopsy, subtotal resection, or gross total resection). Most patients with high-grade lesions received radiotherapy to the craniospinal axis. Low-grade intracranial lesions received more limited treatment. Spinal cord lesions were treated using either partial spine or whole spine fields. RESULTS: Of 32 intracranial tumors, 21 recurred, all at the primary site; no spinal cord tumors recurred. Overall 10-year survival rates were 51% (absolute) and 46% (relapse-free); by tumor site: spinal cord, 100%; infratentorial, 45%; supratentorial, 20% (p = 0.002). On multivariate analysis, tumor site was the only factor that influenced absolute survival (p = 0.0004); other factors evaluated included grade, gender, age, duration of symptoms, resection extent, primary tumor dose, treatment field extent, surgery-to-radiotherapy interval, and days under radiotherapy treatment. CONCLUSIONS: Patients with supratentorial or infratentorial tumors receive irradiation, regardless of grade. Craniospinal-axis fields are used when spinal seeding is radiographically or pathologically evident. Spinal cord tumors are treated using localized fields to the primary site if not completely resected. Failure to control disease at the primary site remains the main impediment to cure.
Assuntos
Ependimoma/radioterapia , Neoplasias Infratentoriais/radioterapia , Neoplasias da Medula Espinal/radioterapia , Neoplasias Supratentoriais/radioterapia , Adolescente , Adulto , Análise de Variância , Criança , Ependimoma/mortalidade , Feminino , Humanos , Neoplasias Infratentoriais/mortalidade , Masculino , Recidiva Local de Neoplasia , Prognóstico , Radioterapia/efeitos adversos , Neoplasias da Medula Espinal/mortalidade , Neoplasias Supratentoriais/mortalidade , Taxa de SobrevidaRESUMO
Primary intracranial germ cell neoplasms are rare tumors and constitute a heterogeneous group. We have reviewed 32 cases, over a 21-year period, from the University of Florida. The cases include 22 germinomas, 6 mixed germ cell tumors, and 4 teratomas. The clinical presentations in these cases were more closely related to the location of the tumor, that is, pineal or suprasellar, rather than the histologic subtype. Neuroimaging evaluation was useful in distinguishing between germinomas, teratomas, and other mixed germ cell tumors (MGCTs), primarily by evaluation of cystic versus solid lesions (teratoma versus germinoma), contents of cysts (teratoma versus MGCT), and infiltrative nature of the tumors (MGCT), although cytologic-histopathologic confirmation remains necessary. Germinomas responded favorably to radiation therapy with survival periods of over 16 years; MGCTs were treated with combination chemotherapy and radiation, with a markedly poorer prognosis. This study underlines the critical significance of histopathologic evaluation of the tumor in determining therapeutic interventions as well as prognosis.
Assuntos
Neoplasias Encefálicas/patologia , Germinoma/patologia , Teratoma/patologia , Adolescente , Adulto , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/terapia , Quimioterapia Adjuvante , Criança , Pré-Escolar , Feminino , Germinoma/diagnóstico por imagem , Germinoma/mortalidade , Germinoma/terapia , Humanos , Lactente , Recém-Nascido , Imageamento por Ressonância Magnética , Masculino , Radioterapia Adjuvante , Estudos Retrospectivos , Taxa de Sobrevida , Teratoma/diagnóstico por imagem , Teratoma/mortalidade , Teratoma/terapia , Tomografia Computadorizada por Raios XRESUMO
Pediatric brain tumors should be treated at multispecialty centers where the pediatric neurosurgeon constitutes a critical component to the team. Pediatric brain tumors are relatively rare, and diagnosis is often delayed because of the protean manifestations of these tumors clinically. The tumors can occur anywhere along the neuraxis but most commonly in the posterior fossa. The neurosurgeon's role in the care of pediatric patients with brain tumors entails establishing an accurate diagnosis, the treatment of hydrocephalus, the radical and total removal of the offending lesions initially, and the establishment of diagnosis at the time of recurrence. Because of rapid advances in neuroradiology, neuro-oncology, and radiation therapy, most brain tumors in childhood can be eliminated with a high chance for cure and minimal morbidity. The neurosurgeon must be technically adept at radical resection of these tumors even in eloquent areas.
Assuntos
Neoplasias Encefálicas/cirurgia , Procedimentos Neurocirúrgicos , Criança , HumanosRESUMO
OBJECTIVE AND IMPORTANCE: Unresectable cystic brain stem lesions are often responsible for neurological dysfunction. Stereotactic aspiration of such lesions can lead to clinical improvement, but cyst recurrence is common and multiple aspirations may be necessary. CLINICAL PRESENTATION: Three children with unresectable cystic brain stem lesions were treated at the University of Florida. Two patients initially underwent stereotactic biopsy and cystic aspiration, both improving after cystic decompression. Both patients returned 3 months later with symptomatic cyst recurrences requiring further intervention. Six years after surgical resection of a posterior fossa medulloblastoma, the third patient presented with a dorsal midbrain cyst. INTERVENTION: All three patients had catheters placed into the cyst cavities under stereotactic guidance. A subcutaneous Ommaya reservoir was attached to the existing catheter. In the event of symptomatic cyst recurrence, the Ommaya reservoir can be tapped in an outpatient setting. CONCLUSION: Cystic decompression resulted in clinical improvement in all three children. Multiple aspirations were necessary in two patients for symptomatic cyst recurrences. The Ommaya reservoir allows for cyst aspiration in an outpatient setting and avoids multiple stereotactic manipulations. This system may also be used to instill radioisotopes or it may be converted to a cyst-peritoneal shunt if multiple aspirations fail to achieve cystic control.
Assuntos
Neoplasias Encefálicas/cirurgia , Tronco Encefálico/cirurgia , Cateteres de Demora , Cistos/cirurgia , Complicações Pós-Operatórias/cirurgia , Sucção/instrumentação , Astrocitoma/diagnóstico , Astrocitoma/cirurgia , Neoplasias Encefálicas/diagnóstico , Tronco Encefálico/patologia , Neoplasias Cerebelares/diagnóstico , Neoplasias Cerebelares/cirurgia , Criança , Cistos/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Meduloblastoma/diagnóstico , Meduloblastoma/cirurgia , Neurofibromatoses/diagnóstico , Neurofibromatoses/cirurgia , Complicações Pós-Operatórias/diagnóstico , Reoperação , Tomografia Computadorizada por Raios XRESUMO
A rare case of myelinoclastic diffuse sclerosis (MDS), occasionally referred to as Schilder's disease, is reported in a child with Turner's syndrome. The child originally presented with a 3-week history of nausea, vomiting and frontal headaches. Magnetic resonance imaging showed a large, contrast-enhancing, right frontal lobe mass which was ultimately resected uneventfully. Complete laboratory investigations and pathological evaluation of the resected specimen verified the case to be MDS. The clinical presentation, laboratory evaluation, imaging characteristics and diagnosis are discussed in this review of the disease. The importance of including demyelinating diseases in the differential diagnosis for newly discovered mass lesions in the pediatric population is underscored by this case.
Assuntos
Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Esclerose Cerebral Difusa de Schilder/complicações , Esclerose Cerebral Difusa de Schilder/diagnóstico , Lobo Frontal/patologia , Síndrome de Turner/complicações , Neoplasias Encefálicas/cirurgia , Criança , Doenças Desmielinizantes/complicações , Doenças Desmielinizantes/diagnóstico , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Diagnóstico Diferencial , Esclerose Cerebral Difusa de Schilder/tratamento farmacológico , Feminino , Lobo Frontal/cirurgia , Humanos , Resultado do TratamentoRESUMO
The authors report the case of a 36-year-old woman who underwent gross total resection of a right cerebellar pleomorphic xanthoastrocytoma with atypical features. She had undergone surgery 16 years previously for what was thought to be a right frontal glioblastoma multiforme. In retrospect, based on the histopathology and the clinical course, both lesions were considered to represent atypical variants of pleomorphic xanthoastrocytoma. This report examines the histological and clinical characteristics of this posterior fossa lesion, which exhibited histologically malignant features but has run a relatively indolent course.
Assuntos
Astrocitoma/patologia , Astrocitoma/cirurgia , Neoplasias Cerebelares/patologia , Neoplasias Cerebelares/cirurgia , Segunda Neoplasia Primária/patologia , Segunda Neoplasia Primária/cirurgia , Neoplasias Supratentoriais/patologia , Neoplasias Supratentoriais/cirurgia , Adulto , Feminino , HumanosRESUMO
To characterize the temporal course of radiosurgical lesions, 19 cats were irradiated in an animal linear accelerator radiosurgical device. The animals were followed clinically and, at 3.5, 6, 12, 18, 23, 29, and 63 weeks, were studied with gadolinium-enhanced magnetic resonance (MR) imaging. They were then sacrificed after Evans blue dye perfusion, and gross pathological and histopathological studies were performed. Mild neurological deficits developed between 3.5 and 4.5 weeks, correlating with the onset of mass effect both grossly and radiographically and with the maximum amount of white matter edema on T2-weighted MR imaging and microscopic examination. Clinical improvement occurred within several weeks as these resolved. The lesions were of similar size at all time intervals. Gadolinium-enhanced MR imaging demonstrated lesions with peripheral areas of enhancement and central nonenhancing regions which correlated histologically with areas of vascular proliferation and radiation necrosis, respectively. In the early lesions at 3.5 and 6 weeks, necrosis and edema were predominant. From 12 to 29 weeks, an intermediate stage was observed, with resorption of the necrotic debris as evidenced by progressive cavitation and microglial response and by increased perilesional vascularity. At 63 weeks, resorption was still taking place, but gliosis and diminution of the vascular response were seen.
Assuntos
Encéfalo/cirurgia , Lesões Experimentais por Radiação/patologia , Radiocirurgia/efeitos adversos , Animais , Encéfalo/patologia , Encéfalo/efeitos da radiação , Edema Encefálico/diagnóstico , Edema Encefálico/etiologia , Edema Encefálico/patologia , Gatos , Modelos Animais de Doenças , Imageamento por Ressonância Magnética , Necrose , Lesões Experimentais por Radiação/diagnóstico , Lesões Experimentais por Radiação/etiologia , Fatores de TempoRESUMO
A 12-year-old caucasian boy presented with a thoracic myelopathy. Magnetic resonance T1-weighted images revealed an enhancing lesion infiltrating the lower thoracic spinal cord to the level of the conus. Evaluation of the lesion by open biopsy revealed granulomatous angiitis of the spinal cord. Granulomatous angiitis is a rare vasculitic process that typically involves the brain and, less frequently, the spinal cord. Diagnosis must be established early by histopathological examination so that treatment with corticosteroids and/or cytotoxic agents may be instituted. When left untreated, patients with granulomatous angiitis of the spinal cord have developed fatal intracranial manifestations.
Assuntos
Síndrome de Churg-Strauss/diagnóstico , Medula Espinal/irrigação sanguínea , Biópsia , Criança , Síndrome de Churg-Strauss/patologia , Diagnóstico Diferencial , Células Gigantes/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Músculo Liso Vascular/patologia , Medula Espinal/patologiaRESUMO
Between November 1990 and March 1993, nine pediatric patients with newly diagnosed brain tumors having a high risk of failure with standard treatment received high-dose thiotepa/cyclophosphamide chemotherapy followed by autologous bone marrow infusion and involved-field hyperfractionated radiation therapy. The presenting diagnoses were brainstem glioma (BSG) [6], parietal mixed high-grade oligodendroglioma-astrocytoma [1], thalamic anaplastic astrocytoma [1], and high-grade parietal glioma [1]. Following chemotherapy there were two partial responses, one minor response, three with stable disease, and one with progressive disease. Responses were not evaluated in two patients who had toxic deaths. Following radiation two patients, one with brainstem glioma and one with anaplastic mixed glioma, achieved complete remission. The overall survival is no better than conventional therapy.
Assuntos
Neoplasias Encefálicas/terapia , Tronco Encefálico , Ciclofosfamida/uso terapêutico , Glioma/terapia , Adolescente , Transplante de Medula Óssea , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/radioterapia , Criança , Pré-Escolar , Terapia Combinada , Ciclofosfamida/administração & dosagem , Ciclofosfamida/efeitos adversos , Feminino , Glioma/tratamento farmacológico , Glioma/radioterapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Transplante Autólogo , Resultado do TratamentoRESUMO
Thallium-201 chloride single photon emission computed tomography (201Tl SPECT) has been proposed as a diagnostic tool in the assessment of patients with brain tumors. We performed SPECT scans coupled with magnetic resonance imaging (MRI) in children with brain tumors to determine the sensitivity and potential value of SPECT in neuro-oncology. Each patient was injected with 2.5-3.0 mCi of thallium chloride, followed by technetium-99m HMPAO (5-15 mCi) to assess cerebral perfusion. 201Tl uptake was imaged with triple-headed SPECT in 20/24 (83%) histologically and anatomically diverse neoplasms with MRI-measurable residual disease, including 13/16 (80%) posterior fossa tumors. 201Tl SPECT demonstrated uptake in tumors with MRI volumes ranging from 0.03 to 60 cm3. 201Tl SPECT imaging was not correlated with the following MRI features: gadolinium enhancement, necrosis, exophytic, unicentric and multicentric. 201Tl uptake was not detectable in patients with tumors of maldevelopmental origin or radionecrosis. It is suggested that 201Tl SPECT is an important imaging adjunct in the assessment of children with brain tumors.
Assuntos
Neoplasias Encefálicas/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Adolescente , Encéfalo/diagnóstico por imagem , Encéfalo/cirurgia , Neoplasias Encefálicas/terapia , Criança , Pré-Escolar , Terapia Combinada , Feminino , Seguimentos , Humanos , Lactente , Masculino , Recidiva Local de Neoplasia/diagnóstico por imagem , Recidiva Local de Neoplasia/terapia , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/terapia , Compostos de Organotecnécio , Oximas , Tecnécio Tc 99m Exametazima , Radioisótopos de TálioRESUMO
A 9-year-old patient presented with an acute left hemiparesis secondary to an intradural hemorrhage of the cervical spinal cord. Angiography revealed a dural arteriovenous (AV) fistula with multiple venous aneurysms fed by a radicular branch of the right vertebral artery. This AV fistula did not contribute blood flow to the cervical segment of the spinal cord, which was tested by an intra-arterial injection of methohexital. Interruption of the fistula was possible by transluminal embolization with polyvinyl alcohol and silk. At a 6-month follow-up, the patient was neurologically intact, and angiography demonstrated no AV fistula. This case illustrates an unusual presentation of a dural AV fistula. Dural AV fistulas are rare in the cervical region and extremely unusual in patients less than 20 years of age. The lesion proved to be amenable to transluminal embolization alone, without the need for surgery, with a dramatic resolution of the neurological deficit.
Assuntos
Fístula Arteriovenosa/terapia , Dura-Máter/irrigação sanguínea , Embolização Terapêutica , Canal Medular , Medula Espinal/irrigação sanguínea , Artéria Vertebral , Doença Aguda , Fístula Arteriovenosa/complicações , Criança , Hemiplegia/etiologia , Hemorragia/etiologia , Humanos , Injeções Intra-Arteriais , Imageamento por Ressonância Magnética , Masculino , Metoexital/administração & dosagem , Espaço SubduralRESUMO
Gliomas that arise in the brain stem have been associated with a poor prognosis. Diagnostic neuroimaging readily identifies the tumor as it extends between normal brainstem structures. Histologic sampling of tumor with stereotactic methods is notoriously unreliable in establishing a definitive prognosis. Clinical trials that incorporate high-dose chemotherapy, autologous bone marrow rescue, and irradiation hold promise of better tumor control by overcoming the inaccessibility of the central nervous system to standard doses of chemotherapy. We review the pathology, clinical features, neuroimaging features, and current therapeutic concepts relative to brainstem glioma. The pediatric neurologist has a pivotal role in identifying and monitoring children with this malignancy.
Assuntos
Neoplasias Encefálicas/diagnóstico , Tronco Encefálico , Glioma/diagnóstico , Biópsia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/terapia , Tronco Encefálico/patologia , Quimioterapia Adjuvante , Criança , Terapia Combinada , Irradiação Craniana , Diagnóstico Diferencial , Glioma/patologia , Glioma/terapia , Humanos , Imageamento por Ressonância Magnética , Exame Neurológico , Dosagem RadioterapêuticaRESUMO
Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium-enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the higher-dose lesions contained increasing amounts of hemorrhage and coagulative necrosis. The borders of the lesions were sharply demarcated from surrounding normal brain. Gadolinium-enhanced MR studies correlated well with areas of blood-brain barrier breakdown, as confirmed by areas of Evans blue staining. This model could serve as the basis for further studies of the biological effects of LINAC radiosurgery.
Assuntos
Encéfalo/cirurgia , Radiocirurgia/métodos , Animais , Encéfalo/patologia , Encéfalo/efeitos da radiação , Gatos , Relação Dose-Resposta à Radiação , Imageamento por Ressonância MagnéticaRESUMO
Two children developed mental status alteration and bilateral profound visual loss secondary to optic neuritis. The clinical picture was consistent with parainfectious encephalomyelitis. Magnetic resonance imaging showed bilateral involvement of the thalamus in both cases. In one case the thalamic involvement was solitary and was suspected initially to represent a primary thalamic neoplasm. This was ruled out by a stereotactic biopsy of the thalamus, which showed perivascular inflammation consistent with parainfectious encephalomyelitis. The clinical and neuroimaging findings improved significantly following corticosteroid administration. Several relapses occurred upon initial attempts at corticosteroid cessation.
Assuntos
Encefalomielite Aguda Disseminada/etiologia , Neurite Óptica/etiologia , Doenças Talâmicas/etiologia , Pré-Escolar , Meios de Contraste , Vacina contra Difteria, Tétano e Coqueluche/efeitos adversos , Ácido Edético , Encefalomielite Aguda Disseminada/diagnóstico , Encefalomielite Aguda Disseminada/tratamento farmacológico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Imageamento por Ressonância Magnética , Neurite Óptica/diagnóstico , Neurite Óptica/tratamento farmacológico , Compostos Organometálicos , Vacina Antipólio Oral/efeitos adversos , Doenças Talâmicas/diagnóstico , Doenças Talâmicas/tratamento farmacológicoRESUMO
BACKGROUND: Previous studies of patients with heterogeneous, often diffuse neurologic disorders concluded that the neurologic substrate for alternating skew on lateral gaze may be localized at the level of the brain stem tegmentum or the cervico-medullary junction, or both. The localized nature of brain tumors offers an opportunity to further investigate the anatomic localization for this as well as other conditions. METHODS: To test the hypothesis that cervico-medullary and cerebellar lesions are responsible for alternating skew on lateral gaze, the authors investigated a series of 50 children with brain tumors, 39 of whom showed neuro-ophthalmologic abnormalities on clinical testing. Seven children had alternating skew on lateral gaze. RESULTS: All seven children with alternating skew on lateral gaze showed neoplastic involvement at the level of the cervico-medullary junction and/or the cerebellum on critical analysis of neuro-imaging studies. CONCLUSION: The authors conclude that the neuroanatomic substrate for alternating skew on lateral gaze is localized at the level of the cervico-medullary junction and/or the cerebellum. Knowing that (1) alternating skew on lateral gaze closely mimics superior oblique overaction clinically, (2) superior oblique overaction is frequently found in patients with myelomeningocele, and (3) myelomeningocele is uniformly associated with Arnold-Chiari type II which includes cerebellar and cervico-medullary region abnormalities, the authors propose that alternating skew on lateral gaze and superior oblique overaction associated with myelomeningocele have similar neuroanatomic pathways.
Assuntos
Neoplasias Encefálicas/complicações , Transtornos da Motilidade Ocular/etiologia , Músculos Oculomotores/patologia , Vias Visuais/patologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Transtornos da Motilidade Ocular/patologiaRESUMO
Lymphocytic hypophysitis (LH) is a rare inflammatory disease of the pituitary that produces hypopituitarism. It more commonly affects women during pregnancy or shortly after childbirth. Of the 34 reported cases only three have been males. We report the fourth known case of lymphocytic hypophysitis in a male who presented with hypopituitarism, diplopia, and cavernous sinus involvement. To our knowledge this is the second report of involvement of the cavernous sinus by LH. A comparative study of all four male cases is also presented. The findings reveal that the mean age at presentation in the male patients is 52.3, nearly 21 years older than that reported for female cases. Impotence with associated decrease in libido is the most common presenting symptom. Extraocular muscle palsy with associated infiltration of the cavernous sinus is an exclusive finding among male patients with LH. Concerning prognosis, none of the male patients regained pituitary function that had been lost at the time of presentation but required chronic replacement therapy.