Assuntos
Carcinoma Basocelular , Transplante de Órgãos , Neoplasias Cutâneas , Humanos , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/etiologia , Transplante de Órgãos/efeitos adversos , Fatores de Risco , Pele , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Transplantados , Minorias Étnicas e RaciaisRESUMO
We evaluated clinical, phenotypic, behavioral, and histopathologic variables in relationship to melanoma-specific survival by age at diagnosis among 650 population-based melanoma patients in Connecticut, with 20 years of follow-up. Only one variable, skin awareness, was significantly associated with melanoma mortality in both groups. The variables that differed between the age-groups were anatomic site, Breslow thickness, histologic subtype, mitoses, tumor-infiltrating lymphocytes (TILs), and solar elastosis. Head and neck melanoma, Breslow thickness, nodular melanoma, and solar elastosis were all significantly more likely to be associated with mortality among the older subjects; among the younger subjects, the presence of mitoses was associated with an increased probability of dying and TILs were associated with a reduced risk of mortality.
Assuntos
Melanoma/diagnóstico , Melanoma/patologia , Fatores Etários , Idoso , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Melanoma/mortalidade , Pessoa de Meia-Idade , Análise Multivariada , Modelos de Riscos Proporcionais , Análise de SobrevidaRESUMO
Melanoma rates have increased in populations that are mainly European. The main etiologic factor is ultraviolet radiation, from the sun as well as artificial tanning devices. Host factors such as skin color, number of nevi, hair and eye color and tanning ability are critical factors in modifying an individual's response to the sun. Genetic factors interact with host factors and environmental factors to increase risk. This review summarizes our current knowledge of environment and genetics on melanoma risk and on gene-environment interaction.
Assuntos
Melanoma/etiologia , Neoplasias Cutâneas/etiologia , Inibidor de Quinase Dependente de Ciclina p18/genética , Reparo do DNA , Humanos , Melanoma/genética , Nevo/etiologia , Nevo/patologia , Receptor Tipo 1 de Melanocortina/genética , Fatores de Risco , Neoplasias Cutâneas/genética , Curtume , Raios UltravioletaRESUMO
Neural Tube defects are one of the most common congenital disorders, presenting in a paediatric rehabilitation set-up. With its wide spectrum of clinical presentation and possible complications, the condition can significantly impact an individual's functional capacity and quality of life. The condition also affects the family of the child leaving them with a lifelong impairment to cope up with. Through this 16-year-old child, we shed light on the effects of providing rehabilitation, even at a later stage and its benefits. We also get a glimpse of difficulties in availing rehabilitation services in developing countries and the need to reach out many more neglected children like him with good functional abilities.