Radiation development of pH-responsive (xanthan-acrylic acid)/MgO nanocomposite hydrogels for controlled delivery of methotrexate anticancer drug.

Nanocomposite hydrogels composed of magnesium oxide (MgO) and natural polymer-based copolymer of Xanthan gum (Xan) and acrylic acid (AAc) were prepared using radiation-induced copolymerization and crosslinking technique to be used as a drug delivery system. MgO nanoparticles were synthesized using sol- gel method. FTIR, XRD, UV-vis and TEM analysis revealed the successful preparation of MgO nanoparticles. The size of MgO nanoparticles was found to be 6.6 nm. FTIR data confirmed the incorporation of MgO within the (Xan-AAc) copolymer hydrogel. The presence of MgO nanoparticles slightly decreases the gelation degree and on contrary the swelling degree and network porosity was enhanced. (Xan-AAc)/MgO nanocomposites show typical pH-dependent swelling behavior Moreover, the swelling kinetics showed that all the samples under investigation possess Fickian at pH1 and non-Fickian at pH7. Methotrexate (MTX) as model for anticancer drugs was used to evaluate the potential efficiency of the obtained (Xan-AAc)/MgO nanocomposites as drug carrier. Incorporation of MgO into (Xan-AAc) hydrogel improves the drug loading efficiency and enhances the (MTX) release to reach maximum in the simulated intestine medium (pH7). The drug release profile came in a good agreement with swelling results which recommend the (Xan-AAc)/MgO nanocomposite hydrogels as potential targeted drug delivery system.

Radiation fabrication of Xanthan-based wound dressing hydrogels embedded ZnO nanoparticles: In vitro evaluation.

Depending on the biocompatibility of Xanthan, polyvinyl alcohol and the antibacterial efficiency of zinc oxide nanoparticles (ZnO), a series of (Xanthan-polyvinyl alcohol)/ZnO nanocomposite hydrogels were prepared as wound dressing using eco-friendliness 60Co γ-ray irradiation facility. ZnO nanoparticles were characterized using X-ray diffraction, UV-vis spectroscopy, transmission electron microscopy and energy dispersive X-ray analysis. The size of ZnO nanoparticles was ranged between 15 and 25 nm. The presence of ZnO nanoparticles reconstructed the internal structure of the hydrogel network which aid in a homogenous porous structure as indicated by scanning electron micrographs. Such adequate porosity along with the presence of ZnO nanoparticles controls the fluid uptake ability, water retention and water vapor transmission rate. The fluid uptake ability in pseudo-extracellular fluid and water ranged between (554-664%) and (1281-1603%), respectively. After exposure to air for 6 h, ZnO dressings kept about 50-65% of their water content which makes them more suitable for moderate exudating wounds. Water vapor transmission rate ranged between 167 and 184 (g/(m2 h) which is sufficient to keep wound's surface moist. ZnO dressings show an efficient microbial barrier potency and profound antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans. In vitro cytotoxicity and haemolytic potency evaluation showed their biocompatibility.