Lifestyle and Sociodemographic Parameters Associated with Mental and Physical Health during COVID-19 Confinement in Three Ibero-American Countries. A Cross-Sectional Pilot Study.

BACKGROUND: The aim of the present study was to determine the association between the health-related quality of life (HRQoL) with sociodemographic parameters and lifestyle during COVID-19 confinement in Mexico, Chile, and Spain. METHODS: A cross-sectional pilot study, with 742 observations of online surveys in 422, 190, and 130 individuals from Mexico, Chile, and Spain, respectively. Sociodemographic data, presence of comorbidities, food habits, and physical activity (PA) patterns were evaluated. The HRQoL was evaluated according to the SF-36 Health Survey. The multilinear regression analysis was developed to determine the association of variables with HRQoL and its physical and mental health dimensions. RESULTS: The female sex in the three countries reported negative association with HRQoL (Mexico: ß -4.45, p = 0.004; Chile: ß -8.48, p < 0.001; Spain: ß -6.22, p = 0.009). Similarly, bad eating habits were associated negatively with HRQoL (Mexico: ß -6.64, p < 0.001; Chile: ß -6.66, p = 0.005; Spain: ß -5.8, p = 0.032). In Mexico, PA limitations presented a negative association with HRQoL (ß -4.71, p = 0.011). In Chile, a sedentary lifestyle (h/day) was linked negatively with HRQoL (ß -0.64, p = 0.005). In Spain, the highest associations with HRQoL were the presence of comorbidity (ß -11.03, p < 0.001) and smoking (ß -6.72, p = 0.02). Moreover, the PA limitation in Mexico (ß -5.67, p = 0.023) and Chile (ß -9.26, p = 0.035) was linked negatively with mental health. CONCLUSIONS: The bad eating habits, PA limitations, female sex, comorbidity presence, and smoking were parameters linked negatively with HRQoL.

Influencia del polimorfismo de la enzima convertidora de angiotensina 2 (rs1978124) en la respuesta hemodinámica posterior a la prueba aeróbica submáxima en jóvenes estudiantes chilenos sedentarios / Effect of angiotensin converting enzyme 2 rs1978124 gene polymorphism on the hemodynamic response to exercise

Background: Angiotensin-converting enzyme 2 (ACE2) has a protective role in the regulation of blood pressure. Aim: To evaluate the influence of ACE2 rs1978124 gene polymorphism on the hemodynamic response after a six-minute walk submaximal aerobic test. Material and Methods: A six-minute walk submaximal aerobic test was carried out in 47 men and 55 women, aged 22 ± 2 years. Blood pressure was recorded before and after the test. Pulse rate was recorded continuously. ACE2 polymorphism was determined in DNA extracted from a blood sample. Results: For women, the genotype distribution did not deviate from Hardy-Weinberg equilibrium (x2 = 0.804, d.f. = 1, P = 0.4) and no significant differences in heart rate, systolic and diastolic blood pressure were observed between CC, CT and TT genotypes before and after the test. Among men no differences in these parameters were observed either between the three phenotypes. Conclusions: ACE2 rs1978124 gene polymorphism did not influence the hemodynamic response to submaximal exercise in these participants.